WormBase Tree Display for Gene: WBGene00003858
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| WBGene00003858 | Evidence | Paper_evidence | WBPaper00002840 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | K04G7 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | ogt-1 | Person_evidence | WBPerson346 | |||||
| Sequence_name | K04G7.3 | ||||||||
| Molecular_name | K04G7.3a | ||||||||
| K04G7.3a.1 | |||||||||
| CE25042 | |||||||||
| K04G7.3b | |||||||||
| CE39588 | |||||||||
| K04G7.3b.1 | |||||||||
| Other_name | C. elegans OGT | Paper_evidence | WBPaper00002840 | ||||||
| Ogt | Paper_evidence | WBPaper00046676 | |||||||
| CELE_K04G7.3 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | ogt-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ogt | ||||||||
| Allele (120) | |||||||||
| Possibly_affected_by | WBVar02152826 | ||||||||
| WBVar02157221 | |||||||||
| WBVar02158442 | |||||||||
| WBVar02158444 | |||||||||
| WBVar02158445 | |||||||||
| Strain (16) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (30) | |||||||||
| Ortholog (37) | |||||||||
| Paralog | WBGene00000244 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00003885 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00017983 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00018175 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00021444 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00021613 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00043992 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | ogt-1 encodes an ortholog of O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT; OMIM:300255) with 12 N-terminal tetratricopeptide (TPR) domains (generally thought to enable protein-protein interactions) and a C-terminal putative catalytic domain; although loss of ogt-1 activity has no effect on overall viability or fertility, ogt-1 mutations result in alterations in macronutrient storage and can suppress constitutive dauer formation in daf-2 mutants suggesting that, in C. elegans, ogt-1 may play a regulatory role in nutrient sensing and insulin-like signaling pathways; OGT-1 is expressed in embryos, where it exhibits nuclear and punctate perinuclear localization. | Paper_evidence | WBPaper00002840 | |||||
| WBPaper00026663 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 03 Aug 2006 00:00:00 | ||||||||
| Automated_description | Enables protein N-acetylglucosaminyltransferase activity; protein O-acetylglucosaminyltransferase activity; and protein serine/threonine phosphatase activity. Involved in several processes, including dauer larval development; glycogen metabolic process; and lipid storage. Located in nucleus and perinuclear region of cytoplasm. Expressed in several structures, including hypodermal cell; intestine; neurons; and somatic cell. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in aortic valve stenosis and non-syndromic X-linked intellectual disability 106. Is an ortholog of human OGT (O-linked N-acetylglucosamine (GlcNAc) transferase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:9351 | Homo sapiens | Paper_evidence | WBPaper00058670 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 19 May 2021 00:00:00 | ||||||||
| DOID:9352 | Homo sapiens | Paper_evidence | WBPaper00028382 | ||||||
| WBPaper00026663 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 03 Feb 2020 00:00:00 | ||||||||
| Potential_model | DOID:0080240 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8127) | |||||
| DOID:1712 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8127) | ||||||
| Models_disease_asserted | WBDOannot00000733 | ||||||||
| WBDOannot00000734 | |||||||||
| WBDOannot00000915 | |||||||||
| WBDOannot00000916 | |||||||||
| Molecular_info | Corresponding_CDS | K04G7.3a | |||||||
| K04G7.3b | |||||||||
| Corresponding_CDS_history | K04G7.3:wp153 | ||||||||
| Corresponding_transcript | K04G7.3a.1 | ||||||||
| K04G7.3b.1 | |||||||||
| Other_sequence (62) | |||||||||
| Associated_feature (11) | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr1469 | ||||||||
| Expr12076 | |||||||||
| Expr12077 | |||||||||
| Expr14785 | |||||||||
| Expr15904 | |||||||||
| Expr1011594 | |||||||||
| Expr1031818 | |||||||||
| Expr1153651 | |||||||||
| Expr2014617 | |||||||||
| Expr2032850 | |||||||||
| Drives_construct | WBCnstr00020059 | ||||||||
| WBCnstr00035826 | |||||||||
| WBCnstr00042812 | |||||||||
| Construct_product | WBCnstr00020059 | ||||||||
| WBCnstr00035826 | |||||||||
| WBCnstr00042812 | |||||||||
| WBCnstr00042813 | |||||||||
| WBCnstr00042814 | |||||||||
| WBCnstr00042815 | |||||||||
| WBCnstr00042816 | |||||||||
| WBCnstr00042817 | |||||||||
| WBCnstr00042818 | |||||||||
| Regulate_expr_cluster | WBPaper00046083:ogt-1(ok1474)_OP50_downregulated | ||||||||
| WBPaper00046083:ogt-1(ok1474)_OP50_upregulated | |||||||||
| Antibody | WBAntibody00000148 | ||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (139) | |||||||||
| Interaction (58) | |||||||||
| Map_info | Map | III | Position | -0.779089 | Error | 0.000534 | |||
| Positive | Positive_clone | K04G7 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4355 | |||||||
| 4557 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (51) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
