WormBase Tree Display for Gene: WBGene00003858

WBGene00003858 Evidence: Paper_evidence: WBPaper00002840
  SMap: S_parent: Sequence: K04G7
  Identity: Version: 1
    Name: CGC_name: ogt-1 Person_evidence: WBPerson346
      Sequence_name: K04G7.3
      Molecular_name: K04G7.3a
        K04G7.3a.1
        CE25042
        K04G7.3b
        CE39588
        K04G7.3b.1
      Other_name: C. elegans OGT Paper_evidence: WBPaper00002840
        Ogt Paper_evidence: WBPaper00046676
        CELE_K04G7.3 Accession_evidence: NDB BX284603
      Public_name: ogt-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ogt
    Allele (120)
    Possibly_affected_by: WBVar02152826
      WBVar02157221
      WBVar02158442
      WBVar02158444
      WBVar02158445
    Strain (16)
    RNASeq_FPKM (74)
    GO_annotation (30)
    Ortholog (37)
    Paralog: WBGene00000244 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00003885 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00017983 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00018175 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00021444 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00021613 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00043992 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: ogt-1 encodes an ortholog of O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT; OMIM:300255) with 12 N-terminal tetratricopeptide (TPR) domains (generally thought to enable protein-protein interactions) and a C-terminal putative catalytic domain; although loss of ogt-1 activity has no effect on overall viability or fertility, ogt-1 mutations result in alterations in macronutrient storage and can suppress constitutive dauer formation in daf-2 mutants suggesting that, in C. elegans, ogt-1 may play a regulatory role in nutrient sensing and insulin-like signaling pathways; OGT-1 is expressed in embryos, where it exhibits nuclear and punctate perinuclear localization. Paper_evidence: WBPaper00002840
            WBPaper00026663
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 03 Aug 2006 00:00:00
      Automated_description: Enables protein N-acetylglucosaminyltransferase activity; protein O-acetylglucosaminyltransferase activity; and protein serine/threonine phosphatase activity. Involved in several processes, including dauer larval development; glycogen metabolic process; and lipid storage. Located in nucleus and perinuclear region of cytoplasm. Expressed in several structures, including hypodermal cell; intestine; neurons; and somatic cell. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in aortic valve stenosis and non-syndromic X-linked intellectual disability 106. Is an ortholog of human OGT (O-linked N-acetylglucosamine (GlcNAc) transferase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:9351 Homo sapiens Paper_evidence: WBPaper00058670
          Curator_confirmed: WBPerson324
          Date_last_updated: 19 May 2021 00:00:00
      DOID:9352 Homo sapiens Paper_evidence: WBPaper00028382
            WBPaper00026663
          Curator_confirmed: WBPerson324
          Date_last_updated: 03 Feb 2020 00:00:00
    Potential_model: DOID:0080240 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8127)
      DOID:1712 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8127)
  Models_disease_asserted: WBDOannot00000733
    WBDOannot00000734
    WBDOannot00000915
    WBDOannot00000916
  Molecular_info: Corresponding_CDS: K04G7.3a
      K04G7.3b
    Corresponding_CDS_history: K04G7.3:wp153
    Corresponding_transcript: K04G7.3a.1
      K04G7.3b.1
    Other_sequence (62)
    Associated_feature (11)
  Experimental_info: RNAi_result (11)
    Expr_pattern: Expr1469
      Expr12076
      Expr12077
      Expr14785
      Expr15904
      Expr1011594
      Expr1031818
      Expr1153651
      Expr2014617
      Expr2032850
    Drives_construct: WBCnstr00020059
      WBCnstr00035826
      WBCnstr00042812
    Construct_product: WBCnstr00020059
      WBCnstr00035826
      WBCnstr00042812
      WBCnstr00042813
      WBCnstr00042814
      WBCnstr00042815
      WBCnstr00042816
      WBCnstr00042817
      WBCnstr00042818
    Regulate_expr_cluster: WBPaper00046083:ogt-1(ok1474)_OP50_downregulated
      WBPaper00046083:ogt-1(ok1474)_OP50_upregulated
    Antibody: WBAntibody00000148
    Microarray_results (25)
    Expression_cluster: WBPaper00028451:Oogenic_protein
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:dopaminergic-neurons_larva_enriched
      WBPaper00037950:excretory-cell_larva_enriched
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040412:germline-regulated_daf-16_target
      WBPaper00041954:ethanol_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045314:S.aureus-induced_N2
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00045774:clk-1_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049018:swsn-2.2(RNAi)_downregulated
      WBPaper00049159:Microwave_upregulated_adult
      WBPaper00049217:DAF-16_upregulated
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00049942:HeatShock_downregulated_hsf-1(+)
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050448:KGB-1-induced
      WBPaper00050468:hlh-30-dependent_Cry5B_regulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050496:unc-39(hp701)_regulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:nucleus_specific
      WBPaper00051257:Levamisole_upregulated
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00051310:LIN-41_interacting
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00054192:cold-shock_upregulated
      WBPaper00054913:AKIR-1_interacting_protein
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055648:germline_expressed
      WBPaper00055971:nhl-2(ok818)_20C_upregulated
      WBPaper00056275:P.aeruginosa_upregulated
      WBPaper00056275:P.aeruginosa_upregulated_atf-7(qd22qd130)_dependent
      WBPaper00056275:P.aeruginosa_upregulated_pmk-1(km25)_dependent
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058691:WDR-5.1_interacting_protein
      WBPaper00058969:RIS_enriched
      WBPaper00059254:CSR-1_interacting
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059440:LAG-1_interacting_WholeAnimal
      WBPaper00059471:EGL-43_interacting
      WBPaper00059609:malt-1_ilc-17.1_nfki-1_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00060084:cco-1(RNAi)_upregulated_N2
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061340:Parents_of_PHsh_hyp8_hyp9
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061527:clr-1_21440-mtm-3_16030
      WBPaper00061527:ldb-1_2877-scd-1_3086
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062590:Aging_upregulated_intestine
      WBPaper00064055:trl-1(cas1077)_upregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064159:MRG-1_interacting
      WBPaper00064201:SNA-3_interacting
      WBPaper00064716:paraquat_upregulated
      WBPaper00064735:mys-1(RNAi)_vs_N2_upregulated
      WBPaper00064939:vit-5(RNAi)_upregulated
      WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected
      WBPaper00065258:anchor-cell_enriched
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00032948:StarveUp1
      WBPaper00034739:N2moreDR1350
      WBPaper00035905:FBF-1_Associated
      WBPaper00037695:CC_3-day
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041370:spg-7(RNAi)_upregulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00046083:ogt-1(ok1474)_OP50_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00055899:nitroguanidine_regulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc6390]:Cluster_E
    Interaction (58)
  Map_info: Map: III Position: -0.779089 Error: 0.000534
    Positive: Positive_clone: K04G7 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4355
        4557
    Pseudo_map_position
  Reference (51)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene