WormBase Tree Display for Gene: WBGene00006595
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| WBGene00006595 | Evidence | Paper_evidence | WBPaper00004689 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | M01E5 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | top-1 | |||||||
| Sequence_name | M01E5.5 | ||||||||
| Molecular_name | M01E5.5a | ||||||||
| M01E5.5a.1 | |||||||||
| CE12282 | |||||||||
| M01E5.5b | |||||||||
| CE12284 | |||||||||
| M01E5.5b.1 | |||||||||
| Other_name | DNA topoisomerase I | Paper_evidence | WBPaper00002435 | ||||||
| CELE_M01E5.5 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | top-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | top | ||||||||
| Allele (115) | |||||||||
| Strain | WBStrain00054736 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (23) | |||||||||
| Ortholog (42) | |||||||||
| Structured_description | Concise_description | top-1 encodes the C. elegans DNA topoisomerase I ortholog; TOP-1 exhibits DNA topoisomerase I activity in vitro and in vivo, this activity is required for normal gonad, germline, and embryonic development; top-1 mRNA is expressed throughout the gonad and during early embryogenesis, with mRNA levels nearly gone by hatching; TOP-1 protein levels are highest in embryos and L1 larvae, decrease by the L3 larval stage and then increase again during L4 and adult stages; in meiotic cells, oocytes, and early embryos, TOP-1 localizes to nuclei, while in later embryos TOP-1 is found in gut nucleoli; during cell division of 1-, 2-, and 4-cell embryos, TOP-1 also localizes to centrosomes. | Paper_evidence | WBPaper00002435 | |||||
| WBPaper00004689 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 19 Sep 2006 00:00:00 | ||||||||
| Automated_description | Enables DNA topoisomerase type I (single strand cut, ATP-independent) activity. Predicted to be involved in DNA replication; DNA topological change; and chromosome segregation. Located in nucleolus and spindle pole centrosome. Expressed in several structures, including IL socket cell; excretory cell; gonad; neurons; and oocyte. Is an ortholog of human TOP1 (DNA topoisomerase I) and TOP1MT (DNA topoisomerase I mitochondrial). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | M01E5.5a | |||||||
| M01E5.5b | |||||||||
| Corresponding_transcript | M01E5.5a.1 | ||||||||
| M01E5.5b.1 | |||||||||
| Other_sequence (112) | |||||||||
| Associated_feature | WBsf985817 | ||||||||
| WBsf985818 | |||||||||
| WBsf1011044 | |||||||||
| WBsf218707 | |||||||||
| WBsf218708 | |||||||||
| WBsf218709 | |||||||||
| Experimental_info | RNAi_result (24) | ||||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00015005 | ||||||||
| Antibody | WBAntibody00000181 | ||||||||
| WBAntibody00002325 | |||||||||
| WBAntibody00002326 | |||||||||
| WBAntibody00002327 | |||||||||
| Microarray_results (35) | |||||||||
| Expression_cluster (149) | |||||||||
| Interaction (165) | |||||||||
| Map_info | Map | I | Position | 17.4408 | Error | 0.041867 | |||
| Positive | Positive_clone | M01E5 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (12) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
