WormBase Tree Display for Gene: WBGene00006562
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| WBGene00006562 | Evidence | Person_evidence | WBPerson13 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | K01C8 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | tdc-1 | Person_evidence | WBPerson268 | |||||
| Sequence_name | K01C8.3 | ||||||||
| Molecular_name | K01C8.3a | ||||||||
| K01C8.3a.1 | |||||||||
| CE21011 | |||||||||
| K01C8.3b | |||||||||
| CE28344 | |||||||||
| K01C8.3b.1 | |||||||||
| Other_name | adc-1 | Person_evidence | WBPerson13 | ||||||
| CELE_K01C8.3 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | tdc-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | tdc | ||||||||
| Allele (44) | |||||||||
| Strain | WBStrain00027377 | ||||||||
| WBStrain00027379 | |||||||||
| WBStrain00027424 | |||||||||
| WBStrain00031703 | |||||||||
| WBStrain00034779 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (37) | |||||||||
| Paralog | WBGene00000239 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001839 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006409 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00015467 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004981 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00006418 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00006762 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00007593 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00022427 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | tdc-1 encodes the major C. elegans tyrosine decarboxylase; TDC-1 is an aromatic-L-amino-acid/L-histidine decarboxylase that is required for the synthesis of tyramine and octopamine, and thus for behaviors dependent upon these biogenic amines, including egg laying, locomotion, and touch response; TDC-1 is expressed in the RIC and RIM interneurons, in the gonadal sheath cells, and in the UV1 uterine cells. | Paper_evidence | WBPaper00025096 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 05 Aug 2011 00:00:00 | ||||||||
| Automated_description | Enables tyrosine decarboxylase activity. Involved in octopamine biosynthetic process. Located in axon and neuronal cell body. Expressed in hermaphrodite gonad and lateral ganglion. Human ortholog(s) of this gene implicated in several diseases, including aromatic L-amino acid decarboxylase deficiency; bipolar disorder; and hyperinsulinism. Is an ortholog of human DDC (dopa decarboxylase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3312 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2719) | ||||
| DOID:0090123 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2719) | ||||||
| DOID:14330 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2719) | ||||||
| DOID:655 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2719) | ||||||
| DOID:2018 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2719) | ||||||
| Molecular_info | Corresponding_CDS | K01C8.3a | |||||||
| K01C8.3b | |||||||||
| Corresponding_transcript | K01C8.3a.1 | ||||||||
| K01C8.3b.1 | |||||||||
| Other_sequence (33) | |||||||||
| Associated_feature | WBsf657956 | ||||||||
| WBsf976517 | |||||||||
| WBsf976518 | |||||||||
| WBsf976519 | |||||||||
| WBsf976520 | |||||||||
| WBsf988688 | |||||||||
| WBsf221726 | |||||||||
| WBsf221727 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr3722 | ||||||||
| Expr12137 | |||||||||
| Expr1029134 | |||||||||
| Expr1032701 | |||||||||
| Expr1153336 | |||||||||
| Expr1200227 | |||||||||
| Expr2017366 | |||||||||
| Expr2035503 | |||||||||
| Drives_construct (15) | |||||||||
| Construct_product | WBCnstr00034300 | ||||||||
| WBCnstr00042871 | |||||||||
| Regulate_expr_cluster | WBPaper00060921:tdc-1(n3419)_downregulated | ||||||||
| WBPaper00060921:tdc-1(n3419)_upregulated | |||||||||
| Antibody | WBAntibody00000845 | ||||||||
| Microarray_results (32) | |||||||||
| Expression_cluster (209) | |||||||||
| Interaction (57) | |||||||||
| Map_info | Map | II | Position | 0.755656 | Error | 0.000598 | |||
| Positive | Positive_clone | K01C8 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4726 | |||||||
| 4548 | |||||||||
| 5014 | |||||||||
| 5608 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (59) | |||||||||
| Remark | Originally this gene was named adc-1 (aromatic amino acid decarboxylase). As this gene is required for octopamine biosynthesis and because it can convert tyrosine to tyramine in vitro the tyrosine decarboxylase adc-1 is renamed to tdc-1 [Alkema M][030331 ck1] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
