WormBase Tree Display for Gene: WBGene00013926
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| WBGene00013926 | SMap | S_parent | Sequence | CHROMOSOME_II | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | nep-1 | Person_evidence | WBPerson50 | |||||
| Sequence_name | ZK20.6 | ||||||||
| Molecular_name | ZK20.6 | ||||||||
| ZK20.6.1 | |||||||||
| CE39118 | |||||||||
| Other_name | CELE_ZK20.6 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | nep-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:55 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 05 Jul 2004 15:21:10 | WBPerson1971 | Name_change | CGC_name | nep-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nep | ||||||||
| Allele (36) | |||||||||
| Strain | WBStrain00037607 | ||||||||
| WBStrain00003896 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (47) | |||||||||
| Paralog (24) | |||||||||
| Structured_description | Concise_description | ZK20.6 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; ZK20.6 is closely paralogous to F18A12.8, and orthologous to CG9761 in Drosophila melanogaster; more generally, ZK20.6 falls into a group of proteins that includes the classical neprilysins found in mammals (e.g., PEX [OMIM:307800] and the enkephalin cleaving enzymes). | Paper_evidence | WBPaper00004584 | |||||
| WBPaper00013276 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to be located in plasma membrane. Expressed in RIH and pharynx. Human ortholog(s) of this gene implicated in Alzheimer's disease; artery disease (multiple); congestive heart failure; and dilated cardiomyopathy. Is an ortholog of human ECE1 (endothelin converting enzyme 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3146) | ||||
| DOID:6000 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3146) | ||||||
| DOID:12930 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3146) | ||||||
| DOID:10825 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3146) | ||||||
| DOID:5844 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3146) | ||||||
| DOID:3393 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3146) | ||||||
| DOID:10763 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3146) | ||||||
| Molecular_info | Corresponding_CDS | ZK20.6 | |||||||
| Corresponding_CDS_history | ZK20.6:wp148 | ||||||||
| Corresponding_transcript | ZK20.6.1 | ||||||||
| Other_sequence (49) | |||||||||
| Associated_feature | WBsf989844 | ||||||||
| WBsf1013289 | |||||||||
| WBsf223976 | |||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern | Expr3672 | ||||||||
| Expr1022353 | |||||||||
| Expr1036234 | |||||||||
| Expr1162707 | |||||||||
| Expr2013964 | |||||||||
| Expr2032203 | |||||||||
| Drives_construct | WBCnstr00011590 | ||||||||
| WBCnstr00029439 | |||||||||
| Construct_product | WBCnstr00029439 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (177) | |||||||||
| Interaction (26) | |||||||||
| Map_info | Map | II | Position | 3.8515 | Error | 0.014111 | |||
| Positive | Positive_clone | ZK20 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5505 | |||||||
| 4807 | |||||||||
| 4843 | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00011735 | ||||||||
| WBPaper00019195 | |||||||||
| WBPaper00023670 | |||||||||
| WBPaper00024729 | |||||||||
| WBPaper00026667 | |||||||||
| WBPaper00026731 | |||||||||
| WBPaper00035338 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00064648 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
