WormBase Tree Display for Gene: WBGene00001980
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| WBGene00001980 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | hmr-1 | Person_evidence | WBPerson498 | |||||
| Sequence_name | W02B9.1 | ||||||||
| Molecular_name (13) | |||||||||
| Other_name | CELE_W02B9.1 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | hmr-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hmr | ||||||||
| Allele (936) | |||||||||
| Strain | WBStrain00033419 | ||||||||
| WBStrain00024209 | |||||||||
| WBStrain00024233 | |||||||||
| WBStrain00034583 | |||||||||
| WBStrain00037750 | |||||||||
| WBStrain00022481 | |||||||||
| WBStrain00022484 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (45) | |||||||||
| Ortholog (43) | |||||||||
| Paralog | WBGene00001475 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00017576 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00022103 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00014914 | Caenorhabditis elegans | From_analysis | modENCODE_Pseudogenes | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | hmr-1 encodes two isoforms of a classical cadherin that contain extracellular cadherin, EGF-like, and laminin G domains as well as a highly conserved intracellular domain that binds beta-catenin; by homology, the HMR-1 proteins are predicted to function as calcium-dependent, homophilic cell-cell adhesion receptors; in vivo, HMR-1A activity is required for mediating the cell migrations, cell shape changes, and presumably actin cytoskeleton rearrangements that occur during embryonic tissue and body morphogenesis; HMR-1B is required for fasciculation and outgrowth of a subset of motor neuron processes; HMR-1 antibodies detect expression in all embryonic blastomeres at early stages of development but as hypodermal adherens junctions form and morphogenesis begins, HMR-1 becomes highly expressed in the apical junctions of all hypodermal cells; later, HMR-1 is expressed primarily at the apical margins of hypodermal, pharyngeal, and intestinal cells in a pattern consistent with localization to adherens junctions; an HMR-1B reporter fusion is expressed in neurons, including the DD, VD, and AS class of motor neurons; HMR-1 activity is required for proper localization of other junctional components, such as HMP-1/alpha-catenin and HMP-2/beta-catenin, but not for localization of AJM-1, the junctional component recognized by the MH27 antibody. | Paper_evidence | WBPaper00003046 | |||||
| WBPaper00005031 | |||||||||
| WBPaper00013424 | |||||||||
| WBPaper00040399 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 16 Nov 2011 00:00:00 | ||||||||
| Automated_description | Enables beta-catenin binding activity and delta-catenin binding activity. Involved in cytoskeleton organization; embryo development; and gastrulation. Located in adherens junction; distal dendrite; and plasma membrane. Part of catenin complex. Expressed in several structures, including germline precursor cell; hypodermis; motor neurons; nerve ring; and neuroblasts. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | W02B9.1a | |||||||
| W02B9.1b | |||||||||
| W02B9.1d | |||||||||
| W02B9.1e | |||||||||
| Corresponding_CDS_history | W02B9.1a:wp229 | ||||||||
| W02B9.1c:wp274 | |||||||||
| Corresponding_transcript | W02B9.1a.1 | ||||||||
| W02B9.1a.2 | |||||||||
| W02B9.1b.1 | |||||||||
| W02B9.1d.1 | |||||||||
| W02B9.1e.1 | |||||||||
| Other_sequence (52) | |||||||||
| Associated_feature (71) | |||||||||
| Experimental_info | RNAi_result (61) | ||||||||
| Expr_pattern (17) | |||||||||
| Drives_construct (11) | |||||||||
| Construct_product | WBCnstr00006080 | ||||||||
| WBCnstr00010445 | |||||||||
| WBCnstr00014624 | |||||||||
| WBCnstr00014629 | |||||||||
| WBCnstr00014630 | |||||||||
| WBCnstr00014636 | |||||||||
| WBCnstr00020940 | |||||||||
| WBCnstr00021692 | |||||||||
| WBCnstr00021693 | |||||||||
| WBCnstr00023099 | |||||||||
| Antibody | WBAntibody00000169 | ||||||||
| WBAntibody00002173 | |||||||||
| WBAntibody00002591 | |||||||||
| WBAntibody00002643 | |||||||||
| WBAntibody00002693 | |||||||||
| Microarray_results (38) | |||||||||
| Expression_cluster (173) | |||||||||
| Interaction (109) | |||||||||
| WBProcess | WBbiopr:00000073 | ||||||||
| Map_info | Map | I | Position | 6.60962 | Error | 0.05706 | |||
| Positive | Positive_clone | W02B9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4410 | |||||||
| 4851 | |||||||||
| 4818 | |||||||||
| 5481 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (111) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
