WormBase Tree Display for Gene: WBGene00001475
expand all nodes | collapse all nodes | view schema
| WBGene00001475 | SMap | S_parent | Sequence | CHROMOSOME_V | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | fmi-1 | Person_evidence | WBPerson194 | |||||
| WBPerson481 | |||||||||
| Sequence_name | F15B9.7 | ||||||||
| Molecular_name | F15B9.7a | ||||||||
| F15B9.7a.1 | |||||||||
| CE42459 | |||||||||
| F15B9.7b | |||||||||
| CE50507 | |||||||||
| F15B9.7c | |||||||||
| CE50392 | |||||||||
| F15B9.7b.1 | |||||||||
| F15B9.7c.1 | |||||||||
| Other_name | cdh-6 | Person_evidence | WBPerson698 | ||||||
| CELE_F15B9.7 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | fmi-1 | ||||||||
| DB_info | Database | AceView | gene | 5N513 | |||||
| WormQTL | gene | WBGene00001475 | |||||||
| WormFlux | gene | WBGene00001475 | |||||||
| NDB | locus_tag | CELE_F15B9.7 | |||||||
| Panther | gene | CAEEL|EnsemblGenome=WBGene00001475|UniProtKB=G5EDK5 | |||||||
| family | PTHR24026 | ||||||||
| NCBI | gene | 179788 | |||||||
| RefSeq | protein | NM_001313143.3 | |||||||
| NM_001313142.3 | |||||||||
| NM_073855.6 | |||||||||
| SwissProt | UniProtAcc | G5EDK5 | |||||||
| UniProt_GCRP | UniProtAcc | G5EDK5 | |||||||
| OMIM | gene | 604523 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 30 Sep 2009 14:20:01 | WBPerson1847 | Event | Acquires_merge | WBGene00000398 | ||||
| Acquires_merge | WBGene00000398 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | fmi | ||||||||
| Allele (194) | |||||||||
| Strain | WBStrain00040023 | ||||||||
| WBStrain00040028 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (46) | |||||||||
| Paralog | WBGene00017576 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WBGene00001980 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00022103 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00014914 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | fmi-1 encodes a highly conserved cadherin-like protein with unique domain composition of six EGF and two laminin G domains, a GPS cleavage site and seven-pass transmembrane domain; fmi-1 plays a crucial role in pioneer axon navigation as well as pioneer-mediated follower navigation; FMI-1 is required cell autonomously in pioneer and partially non-cell autonomously in the follower; different domains of FMI-1 are required for pioneer and follower navigation; mutations in fmi-1 cause strong axon navigation defects of VNC pioneer axons; HSN axons are more susceptible to changes in fmi-1 protein; LIN-17/frizzled functions together with fmi-1 in follower axon navigation; in addition, FMI-1 functions together with the CDH-4 cadherin to regulate GABAergic neuronal development; FMI-1 is expressed in neurons and localized to pioneer and follower axons during and after nervous system development; in the embryos FMI-1::GFP is found in axons in the nerve ring, the tail and along the dendrites of sensory neurons. | Paper_evidence | WBPaper00037648 | |||||
| WBPaper00040906 | |||||||||
| Curator_confirmed | WBPerson12884 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 05 Jul 2012 00:00:00 | ||||||||
| Automated_description | Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Involved in anterior/posterior axon guidance and interneuron axon guidance. Located in axon. Expressed in nervous system and somatic nervous system. Human ortholog(s) of this gene implicated in hereditary lymphedema. Is an ortholog of human CELSR2 (cadherin EGF LAG seven-pass G-type receptor 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050580 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1850) | ||||
| Molecular_info | Corresponding_CDS | F15B9.7a | |||||||
| F15B9.7b | |||||||||
| F15B9.7c | |||||||||
| Corresponding_CDS_history | F15B9.7:wp138 | ||||||||
| F15B9.7:wp188 | |||||||||
| Corresponding_transcript | F15B9.7a.1 | ||||||||
| F15B9.7b.1 | |||||||||
| F15B9.7c.1 | |||||||||
| Other_sequence | CRC05304_1 | ||||||||
| JI163786.1 | |||||||||
| JI163891.1 | |||||||||
| CR04693 | |||||||||
| JI163835.1 | |||||||||
| JI163797.1 | |||||||||
| Associated_feature (36) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00066947 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00001265 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101845 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00044701 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00000627 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00013361 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (13) | |||||||||
| Drives_construct (11) | |||||||||
| Construct_product (11) | |||||||||
| Antibody | WBAntibody00002321 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (286) | |||||||||
| Interaction (26) | |||||||||
| Anatomy_function | WBbtf0831 | ||||||||
| WBbtf0832 | |||||||||
| Map_info | Map | V | Position | 4.81313 | Error | 0.003033 | |||
| Positive | Positive_clone | F15B9 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4295 | |||||||
| 4482 | |||||||||
| Reference (34) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
