WormBase Tree Display for Gene: WBGene00002245
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| WBGene00002245 | SMap | S_parent | Sequence | CHROMOSOME_IV | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | lag-1 | Person_evidence | WBPerson320 | |||||
| Sequence_name | K08B4.1 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | CELE_K08B4.1 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | lag-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lag | ||||||||
| Allele (226) | |||||||||
| Possibly_affected_by | WBVar02153178 | ||||||||
| WBVar02157780 | |||||||||
| Legacy_information | [Lambie EJ] larval arrest at L1, characteristic Lag (Lin-12 and Glp-1) phenotype: rectum/anus and excretory cell absent (98%), sometimes twisted nose (12%). NA6 (other alleles weaker: q416 sometimes viable and fertile at 20C; q426 low larval lethality) | ||||||||
| [C.elegansII] q385 : larval arrest at L1, characteristic Lag (Lin-12 and Glp-1) phenotype: rectum/anus and excretory cell absent (98%), sometimes twisted nose (12%). OA>10 (other alleles mostly weaker): q416 (sometimes viable and fertile at 20C), q426 (low larval lethality), om13 (viable, impenetrant embryonic and larval lethality; strong Ego, enhances glp-1(bn18ts)), om27(viable, Ego), om108 (viable, Ego), etc. Cloned: 2.6 kb transcript, encodes protein with high similarity to Drosophila Suppressor of hairless. [Lambie and Kimble 1991; JK] | |||||||||
| Strain | WBStrain00022545 | ||||||||
| WBStrain00022552 | |||||||||
| WBStrain00034581 | |||||||||
| WBStrain00007146 | |||||||||
| WBStrain00030024 | |||||||||
| WBStrain00051949 | |||||||||
| WBStrain00052019 | |||||||||
| WBStrain00051599 | |||||||||
| WBStrain00051810 | |||||||||
| WBStrain00054794 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (59) | |||||||||
| Ortholog (59) | |||||||||
| Structured_description | Concise_description | lag-1 encodes a transcription factor orthologous to members of the CSL (CBF1, Suppressor of Hairless, LAG-1) family that is highly conserved amongst metazoans; during development, LAG-1 functions as a downstream effector in both the lin-12- and glp-1-mediated Notch-like signaling pathways and accordingly, is required for such processes as germline induction, AC/VU lateral signaling, and embryonic development; LAG-1 can bind a consensus CSL family binding site found in multiple copies in the predicted regulatory regions of lin-12, glp-1, and lag-1, thus implicating LAG-1 as an important component of the positive feedback loop observed in the LIN-12/GLP-1 signaling pathway. | Paper_evidence | WBPaper00001423 | |||||
| WBPaper00002452 | |||||||||
| WBPaper00004120 | |||||||||
| WBPaper00004589 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 05 Jun 2006 00:00:00 | ||||||||
| Automated_description | Enables Notch binding activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator binding activity. Involved in several processes, including cell differentiation; dauer exit; and regulation of DNA-templated transcription. Located in nucleus. Part of RNA polymerase II transcription regulator complex and chromatin. Expressed in several structures, including P4.p; P5.p; P6.p; P7.p; and P8.p. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and dilated cardiomyopathy. Is an ortholog of human RBPJ (recombination signal binding protein for immunoglobulin kappa J region). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:12930 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5724) | ||||
| DOID:0060227 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5724) | ||||||
| Molecular_info | Corresponding_CDS | K08B4.1a | |||||||
| K08B4.1b | |||||||||
| K08B4.1c | |||||||||
| K08B4.1d | |||||||||
| Corresponding_transcript | K08B4.1a.1 | ||||||||
| K08B4.1b.1 | |||||||||
| K08B4.1c.1 | |||||||||
| K08B4.1d.1 | |||||||||
| Other_sequence (53) | |||||||||
| Associated_feature (33) | |||||||||
| Gene_product_binds (26) | |||||||||
| Transcription_factor | WBTranscriptionFactor000101 | ||||||||
| Experimental_info (11) | |||||||||
| Map_info | Map | IV | Position | 2.97979 | Error | 0.005015 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F43A12 | |||||||
| K08B4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| M02G2 | |||||||||
| Negative | Negative_clone | M03D4 | |||||||
| Mapping_data | Multi_point | 2827 | |||||||
| 2828 | |||||||||
| 3371 | |||||||||
| 3372 | |||||||||
| 3373 | |||||||||
| 3374 | |||||||||
| 4900 | |||||||||
| Reference (143) | |||||||||
| Remark | data extracted from Lambie & Kimble 1991 | ||||||||
| Datum extracted from Christensen et al. (1996) | |||||||||
| M03D4.3 has been fused with K08B4.1, latter is lag-1 in sequence annotation. [sdm 05/00] | |||||||||
| Method | Gene |
