WormBase Tree Display for Gene: WBGene00007732

WBGene00007732 SMap: S_parent: Sequence: C25G4
  Identity: Version: 5
    Name: CGC_name: spe-44 Paper_evidence: WBPaper00041071
          Person_evidence: WBPerson725
      Sequence_name: C25G4.4
      Molecular_name: C25G4.4
        C25G4.4.1
        CE05305
      Other_name: gmeb-4 Person_evidence: WBPerson260
        tag-347
        CELE_C25G4.4 Accession_evidence: NDB BX284604
      Public_name: spe-44
    DB_info: Database: AceView gene 4N218
        WormQTL gene WBGene00007732
        WormFlux gene WBGene00007732
        NDB locus_tag CELE_C25G4.4
        Panther gene CAEEL|WormBase=WBGene00007732|UniProtKB=Q18171
          family PTHR10417
        NCBI gene 182915
        RefSeq protein NM_069978.6
        SwissProt UniProtAcc Q18171
        TREEFAM TREEFAM_ID TF317090
        UniProt_GCRP UniProtAcc Q18171
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:48 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 21 Jun 2005 09:45:25 WBPerson2970 Name_change: CGC_name: tag-347
        3 22 Sep 2011 11:31:44 WBPerson2970 Name_change: CGC_name: gmeb-4
                Other_name: tag-347
        4 16 Apr 2013 15:53:03 WBPerson2970 Event: Acquires_merge: WBGene00045485
              Name_change: CGC_name: spe-44
                Other_name: gmeb-4
        5 19 Apr 2013 16:40:33 WBPerson2970 Event: Acquires_merge: WBGene00045485
      Acquires_merge: WBGene00045485
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: spe
    Allele (35)
    Strain: WBStrain00033487
      WBStrain00031119
      WBStrain00031120
      WBStrain00033484
      WBStrain00034724
      WBStrain00036311
      WBStrain00051868
      WBStrain00051870
    RNASeq_FPKM (74)
    GO_annotation (13)
    Contained_in_operon: CEOP4516
    Ortholog (36)
    Paralog: WBGene00015285 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00008092 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00010010 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: spe-44 encodes a SAND (for Sp100, Aire, NucP41/75, DEAF-1) domain-containing protein that is one of four C. elegans proteins related to the mammalian glucocorticoid modulatory element-binding proteins GMEB-1 and GMEB-2; SPE-44 is one of the earliest markers of sperm fate and its activity is essential for regulation of sperm-specific genes during spermatogenesis; microarray analyses indicate the SPE-44 is required for expression of a number of sperm-specific genes, including those that encode the Major Sperm Proteins (MSPs), members of the small sperm-specific protein family, other SPE proteins such as SPE-7, and the ELT-1 GATA transcription factor; when expressed in yeast, SPE-44 can directly activate transcription of a lacZ reporter gene containing the spe-7 promoter region; spe-44 expression coincides with commitment to the sperm fate at the L3 larval stage, and persists throughout spermatogenesis in hermaphrodites and males; SPE-44 protein is first detected in the early meiotic zone, co-localizes with meiotic autosomes in the pachytene region, and becomes non-chromosomal before disappearing in karyosome stage nuclei; spe-44 expression is controlled by terminal regulators of the germline sex determination pathway, such as fem-1, fem-3, and fog-1. Paper_evidence: WBPaper00041071
          Curator_confirmed: WBPerson1843
          Date_last_updated: 16 Apr 2013 00:00:00
      Automated_description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in positive regulation of transcription by RNA polymerase II and spermatogenesis. Located in autosome. Expressed in germ line; sperm; and in male. Is an ortholog of human GMEB1 (glucocorticoid modulatory element binding protein 1) and GMEB2 (glucocorticoid modulatory element binding protein 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C25G4.4
    Corresponding_transcript: C25G4.4.1
    Associated_feature: WBsf668432
      WBsf668433
      WBsf978427
      WBsf231024
    Transcription_factor: WBTranscriptionFactor000616
  Experimental_info: RNAi_result: WBRNAi00041213 Inferred_automatically: RNAi_primary
      WBRNAi00076159 Inferred_automatically: RNAi_primary
      WBRNAi00011180 Inferred_automatically: RNAi_primary
      WBRNAi00029204 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr10041
      Expr11705
      Expr11706
      Expr1014891
      Expr1033347
      Expr1145249
      Expr1200179
      Expr2016042
      Expr2034277
    Drives_construct: WBCnstr00037868
    Construct_product: WBCnstr00037868
    Regulate_expr_cluster: WBPaper00041071:spe-44_downregulated
      WBPaper00041071:spe-44_upregulated
      WBPaper00064502:nhr-23(kry61);spe-44(fx110)_downregulated
      WBPaper00064502:nhr-23(kry61);spe-44(fx110)_upregulated
      WBPaper00064502:spe-44(fx110)_downregulated
      WBPaper00064502:spe-44(fx110)_upregulated
    Antibody: WBAntibody00002339
    Microarray_results (20)
    Expression_cluster (129)
    Interaction (80)
  Map_info: Map: IV Position: 5.96572 Error: 0.006805
    Positive: Positive_clone: C25G4 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5281
    Pseudo_map_position
  Reference (15)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene