WormBase Tree Display for Gene: WBGene00004955
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| WBGene00004955 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F56A3 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | spd-5 | Person_evidence | WBPerson689 | |||||
| Sequence_name | F56A3.4 | ||||||||
| Molecular_name | F56A3.4 | ||||||||
| F56A3.4.1 | |||||||||
| CE28834 | |||||||||
| F56A3.4.2 | |||||||||
| Other_name | CELE_F56A3.4 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | spd-5 | ||||||||
| DB_info | Database | AceView | gene | 1F740 | |||||
| WormQTL | gene | WBGene00004955 | |||||||
| WormFlux | gene | WBGene00004955 | |||||||
| NDB | locus_tag | CELE_F56A3.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004955|UniProtKB=P91349 | |||||||
| family | PTHR18861 | ||||||||
| NCBI | gene | 172155 | |||||||
| RefSeq | protein | NM_059138.6 | |||||||
| SwissProt | UniProtAcc | P91349 | |||||||
| TREEFAM | TREEFAM_ID | TF351146 | |||||||
| UniProt_GCRP | UniProtAcc | P91349 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | spd | ||||||||
| Allele (68) | |||||||||
| Legacy_information | [B Bowerman] defects in first cell cycle - pronuclear migration is defective, the mitotic spindle does not form, and cell division fails. (RNAi phenocopies mutant phenotype) | ||||||||
| Complementation_data | [B Bowerman] complements let-371(h123) and let-359(h94) and let-361(h97) and let-363(h98) and let-364(h104) | ||||||||
| Strain | WBStrain00007312 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog (30) | |||||||||
| Structured_description | Concise_description | spd-5 encodes a coiled-coil domain protein; spd-5 activity is required for centrosome maturation, symmetry breaking, pronuclear migration, mitotic spindle assembly, and cell division; in regulating centrosome maturation, spd-5 interacts genetically with spd-2, which also encodes a coiled-coil protein; SPD-5 physically interacts with CED-9, a C. elegans BCL2 ortholog and spd-5(RNAi) results in increased germline apoptosis, suggesting an additional role for SPD-5 in regulation of apoptosis; SPD-5 localizes to the pericentriolar material. | Paper_evidence | WBPaper00005565 | |||||
| WBPaper00013411 | |||||||||
| WBPaper00024623 | |||||||||
| WBPaper00035332 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 22 Sep 2010 00:00:00 | ||||||||
| Automated_description | Enables identical protein binding activity. Involved in centrosome cycle; positive regulation of mitotic cell cycle, embryonic; and protein localization to organelle. Located in centrosome and cytoplasm. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F56A3.4 | |||||||
| Corresponding_transcript | F56A3.4.1 | ||||||||
| F56A3.4.2 | |||||||||
| Other_sequence | CSC01762_1 | ||||||||
| CR04887 | |||||||||
| CJC08874_1 | |||||||||
| CRC06387_1 | |||||||||
| CRC12526_1 | |||||||||
| CBC14483_1 | |||||||||
| CR07690 | |||||||||
| CBC00733_1 | |||||||||
| FD515205.1 | |||||||||
| Associated_feature | WBsf649147 | ||||||||
| WBsf663766 | |||||||||
| WBsf664207 | |||||||||
| WBsf983615 | |||||||||
| WBsf1009776 | |||||||||
| WBsf219379 | |||||||||
| WBsf219380 | |||||||||
| WBsf219381 | |||||||||
| WBsf219382 | |||||||||
| Experimental_info | RNAi_result (27) | ||||||||
| Expr_pattern | Expr2284 | ||||||||
| Expr1028819 | |||||||||
| Expr1032469 | |||||||||
| Expr1152370 | |||||||||
| Expr2016027 | |||||||||
| Expr2034262 | |||||||||
| Drives_construct | WBCnstr00018011 | ||||||||
| WBCnstr00035306 | |||||||||
| Construct_product (13) | |||||||||
| Antibody | WBAntibody00000572 | ||||||||
| WBAntibody00000573 | |||||||||
| WBAntibody00000748 | |||||||||
| WBAntibody00000823 | |||||||||
| WBAntibody00001882 | |||||||||
| WBAntibody00002101 | |||||||||
| WBAntibody00002307 | |||||||||
| WBAntibody00002641 | |||||||||
| WBAntibody00002823 | |||||||||
| WBAntibody00003025 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (158) | |||||||||
| Interaction (291) | |||||||||
| WBProcess | WBbiopr:00000017 | ||||||||
| Map_info | Map | I | Position | -0.328477 | Error | 0.002207 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F56A3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4002 | |||||||
| 4003 | |||||||||
| 4004 | |||||||||
| Reference (76) | |||||||||
| Remark | Sequence connection from [Hamill DR, Bowerman B] | ||||||||
| Method | Gene |
