WormBase Tree Display for Gene: WBGene00012458
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| WBGene00012458 | SMap | S_parent | Sequence | Y17G7B | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | ash-2 | Person_evidence | WBPerson342 | |||||
| WBPerson421 | |||||||||
| Sequence_name | Y17G7B.2 | ||||||||
| Molecular_name (13) | |||||||||
| Other_name | Y17G7B.2a | Paper_evidence | WBPaper00003938 | ||||||
| CELE_Y17G7B.2 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | ash-2 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:53 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 16 Oct 2007 10:47:44 | WBPerson2970 | Name_change | CGC_name | ash-2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ash | ||||||||
| Allele (344) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Contained_in_operon | CEOP2584 | ||||||||
| Ortholog (38) | |||||||||
| Structured_description | Concise_description | ash-2 encodes the C. elegans ortholog of Drosophila Ash2, a trithorax group protein that is a member of the conserved H3K4 trimethylation (H3K4me3) complex; in C. elegans, loss of ash-2 via RNAi results in reduced levels of H3K4me3 at L3 larval stages indicating that ASH-2 functions in H3K4 trimethylation; ASH-2 also functions in the C. elegans germline to negatively regulate lifespan; in addition, loss of ash-2 activity via RNAi results in embryonic lethality characterized by defects in cortical activity and spindle rocking; loss of ash-2 activity in a lin-35 mutant background results in reduced brood size and lethality; two ash-2 deletion mutations, tm1903 and tm1905, also result in lethality and sterility; ASH-2 is highly expressed in the germ line and in early embryos; ASH-2 localizes to the nucleus. | Paper_evidence | WBPaper00025054 | |||||
| WBPaper00029258 | |||||||||
| WBPaper00036383 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 20 Sep 2010 00:00:00 | ||||||||
| Automated_description | Predicted to enable transcription cis-regulatory region binding activity. Involved in determination of adult lifespan; programmed cell death; and transdifferentiation. Located in nucleus. Part of MLL3/4 complex. Expressed in germ line. Is an ortholog of human ASH2L (ASH2 like, histone lysine methyltransferase complex subunit). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y17G7B.2a | |||||||
| Y17G7B.2b | |||||||||
| Y17G7B.2d | |||||||||
| Y17G7B.2e | |||||||||
| Corresponding_CDS_history | Y17G7B.2c:wp253 | ||||||||
| Corresponding_transcript | Y17G7B.2c | ||||||||
| Y17G7B.2a.1 | |||||||||
| Y17G7B.2b.1 | |||||||||
| Y17G7B.2d.1 | |||||||||
| Y17G7B.2e.1 | |||||||||
| Other_sequence (35) | |||||||||
| Associated_feature (18) | |||||||||
| Experimental_info | RNAi_result (18) | ||||||||
| Expr_pattern | Expr9083 | ||||||||
| Expr9084 | |||||||||
| Expr1012339 | |||||||||
| Expr1035511 | |||||||||
| Expr1159083 | |||||||||
| Expr2009451 | |||||||||
| Expr2027688 | |||||||||
| Drives_construct | WBCnstr00013709 | ||||||||
| Construct_product | WBCnstr00013709 | ||||||||
| Regulate_expr_cluster | WBPaper00036383:ash-2_Day8_regulated | ||||||||
| WBPaper00036383:ash-2_L3_regulated | |||||||||
| WBPaper00045861:ash-2(tm1095)_downregulated | |||||||||
| WBPaper00045861:ash-2(tm1095)_upregulated | |||||||||
| WBPaper00051039:ash-2(RNAi)_regulated_germline | |||||||||
| WBPaper00051039:ash-2(RNAi)_regulated_intestine | |||||||||
| WBPaper00066232:ash-2(RNAi)_downregulated_WT | |||||||||
| WBPaper00066232:ash-2(RNAi)_upregulated_WT | |||||||||
| Antibody | WBAntibody00002148 | ||||||||
| Microarray_results (36) | |||||||||
| Expression_cluster (94) | |||||||||
| Interaction (53) | |||||||||
| Map_info | Map | II | Position | 5.53877 | Error | 0.083198 | |||
| Positive | Positive_clone | Y17G7B | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (28) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
