WormBase Tree Display for Gene: WBGene00007167

WBGene00007167 SMap: S_parent: Sequence: B0393
  Identity: Version: 3
    Name: CGC_name: rbg-3 Person_evidence: WBPerson657
      Sequence_name: B0393.2
      Molecular_name: B0393.2
        B0393.2.1
        CE00855
        B0393.2.2
      Other_name: tbc-5 Person_evidence: WBPerson524
            WBPerson293
        CELE_B0393.2 Accession_evidence: NDB BX284603
      Public_name: rbg-3
    DB_info: Database: AceView gene 3F845
        WormQTL gene WBGene00007167
        WormFlux gene WBGene00007167
        NDB locus_tag CELE_B0393.2
        Panther gene CAEEL|WormBase=WBGene00007167|UniProtKB=Q17491
          family PTHR22957
        NCBI gene 175629
        RefSeq protein NM_065578.7
        TREEFAM TREEFAM_ID TF105784
        TrEMBL UniProtAcc Q17491
        UniProt_GCRP UniProtAcc Q17491
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:47 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 14 Sep 2005 10:27:05 WBPerson2970 Name_change: CGC_name: rbg-3
        3 23 Jun 2008 18:34:24 WBPerson2970 Name_change: Other_name: tbc-5
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: rbg
    Allele (37)
    Component_of_genotype: WBGenotype00000017
    RNASeq_FPKM (74)
    GO_annotation: 00058275
      00058276
      00058277
    Contained_in_operon: CEOP3866
    Ortholog (34)
    Paralog (17)
    Structured_description: Concise_description: rbg-3 encodes a predicted TBC domain-containing RabGTPase-activating protein (RabGAP) similar to the Ypt/Rab specific GTPase-activating protein gyp6; YPT/Rab GTPases and GAPs regulate eukaryotic vesicular transport; RBG-3 functions as a GTPase for both human and elegans RAB-7; rbg-3 interacts with tub-1/Tubby in yeast two-hybrid screens and regulates fat storage along with tub-1, but not life span, suggesting that rbg-3 could function in a endocytic pathway as a target of tub-1 for regulation of fat storage; rbg-3 is expressed in the amphid and phasmid neurons in the head and localizes to the cytoplasm, this is similar to the expression pattern of tub-1. Paper_evidence: WBPaper00026699
            WBPaper00030935
          Curator_confirmed: WBPerson324
          Date_last_updated: 10 Jan 2012 00:00:00
      Automated_description: Enables GTPase activator activity. Located in cytoplasm. Expressed in amphid neurons and phasmid neurons. Used to study obesity. Is an ortholog of human TBC1D5 (TBC1 domain family member 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:9970
  Models_disease_asserted: WBDOannot00000027
  Molecular_info: Corresponding_CDS: B0393.2
    Corresponding_transcript: B0393.2.1
      B0393.2.2
    Other_sequence (39)
    Associated_feature: WBsf645121
      WBsf658858
      WBsf224793
  Experimental_info: RNAi_result: WBRNAi00007603 Inferred_automatically: RNAi_primary
      WBRNAi00061102 Inferred_automatically: RNAi_primary
      WBRNAi00005493 Inferred_automatically: RNAi_primary
      WBRNAi00000354 Inferred_automatically: RNAi_primary
      WBRNAi00103149 Inferred_automatically: RNAi_primary
      WBRNAi00039007 Inferred_automatically: RNAi_primary
      WBRNAi00028119 Inferred_automatically: RNAi_primary
      WBRNAi00009741 Inferred_automatically: RNAi_primary
      WBRNAi00061101 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr3659
      Expr1020761
      Expr1033083
      Expr1143172
      Expr2015270
      Expr2033504
    Drives_construct: WBCnstr00011579
      WBCnstr00033953
    Construct_product: WBCnstr00011579
      WBCnstr00033953
    Microarray_results (21)
    Expression_cluster (117)
    Interaction (104)
    WBProcess: WBbiopr:00000121
  Map_info: Map: III Position: -2.57882 Error: 0.009833
    Positive: Positive_clone: B0393 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5500
        4625
    Pseudo_map_position
  Reference: WBPaper00026147
    WBPaper00026699
    WBPaper00030935
    WBPaper00038491
    WBPaper00043173
    WBPaper00044609
    WBPaper00047687
    WBPaper00051758
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene