WormBase Tree Display for Gene: WBGene00007167

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WBGene00007167	SMap	S_parent	Sequence	B0393
	Identity	Version	3
		Name	CGC_name	rbg-3	Person_evidence	WBPerson657
			Sequence_name	B0393.2
			Molecular_name	B0393.2
				B0393.2.1
				CE00855
				B0393.2.2
			Other_name	tbc-5	Person_evidence	WBPerson524
						WBPerson293
				CELE_B0393.2	Accession_evidence	NDB	BX284603
			Public_name	rbg-3
		DB_info	Database	AceView	gene	3F845
				WormQTL	gene	WBGene00007167
				WormFlux	gene	WBGene00007167
				NDB	locus_tag	CELE_B0393.2
				Panther	gene	CAEEL\|WormBase=WBGene00007167\|UniProtKB=Q17491
					family	PTHR22957
				NCBI	gene	175629
				RefSeq	protein	NM_065578.7
				TREEFAM	TREEFAM_ID	TF105784
				TrEMBL	UniProtAcc	Q17491
				UniProt_GCRP	UniProtAcc	Q17491
		Species	Caenorhabditis elegans
		History	Version_change	1	26 May 2004 16:54:47	WBPerson1971	Event	Imported	Initial conversion from CDS class of WS125
				2	14 Sep 2005 10:27:05	WBPerson2970	Name_change	CGC_name	rbg-3
				3	23 Jun 2008 18:34:24	WBPerson2970	Name_change	Other_name	tbc-5
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	rbg
		Allele (37)
		Component_of_genotype	WBGenotype00000017
		RNASeq_FPKM (74)
		GO_annotation	00058275
			00058276
			00058277
		Contained_in_operon	CEOP3866
		Ortholog (34)
		Paralog (17)
		Structured_description	Concise_description	rbg-3 encodes a predicted TBC domain-containing RabGTPase-activating protein (RabGAP) similar to the Ypt/Rab specific GTPase-activating protein gyp6; YPT/Rab GTPases and GAPs regulate eukaryotic vesicular transport; RBG-3 functions as a GTPase for both human and elegans RAB-7; rbg-3 interacts with tub-1/Tubby in yeast two-hybrid screens and regulates fat storage along with tub-1, but not life span, suggesting that rbg-3 could function in a endocytic pathway as a target of tub-1 for regulation of fat storage; rbg-3 is expressed in the amphid and phasmid neurons in the head and localizes to the cytoplasm, this is similar to the expression pattern of tub-1.	Paper_evidence	WBPaper00026699
						WBPaper00030935
					Curator_confirmed	WBPerson324
					Date_last_updated	10 Jan 2012 00:00:00
			Automated_description	Enables GTPase activator activity. Located in cytoplasm. Expressed in amphid neurons and phasmid neurons. Used to study obesity. Is an ortholog of human TBC1D5 (TBC1 domain family member 5).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Disease_info	Experimental_model	DOID:9970
	Models_disease_asserted	WBDOannot00000027
	Molecular_info	Corresponding_CDS	B0393.2
		Corresponding_transcript	B0393.2.1
			B0393.2.2
		Other_sequence (39)
		Associated_feature	WBsf645121
			WBsf658858
			WBsf224793
	Experimental_info	RNAi_result	WBRNAi00007603	Inferred_automatically	RNAi_primary
			WBRNAi00061102	Inferred_automatically	RNAi_primary
			WBRNAi00005493	Inferred_automatically	RNAi_primary
			WBRNAi00000354	Inferred_automatically	RNAi_primary
			WBRNAi00103149	Inferred_automatically	RNAi_primary
			WBRNAi00039007	Inferred_automatically	RNAi_primary
			WBRNAi00028119	Inferred_automatically	RNAi_primary
			WBRNAi00009741	Inferred_automatically	RNAi_primary
			WBRNAi00061101	Inferred_automatically	RNAi_primary
		Expr_pattern	Expr3659
			Expr1020761
			Expr1033083
			Expr1143172
			Expr2015270
			Expr2033504
		Drives_construct	WBCnstr00011579
			WBCnstr00033953
		Construct_product	WBCnstr00011579
			WBCnstr00033953
		Microarray_results (21)
		Expression_cluster	WBPaper00031040:TGF-beta_adult_downregulated
			WBPaper00032031:DConiospora_upregulated_cDNA_24h
			WBPaper00032097:CGH-1-associated-mRNA
			WBPaper00033065:cyc-1(RNAi)_downregulated
			WBPaper00037682:sma-2_sma-4_downregulated
			WBPaper00040221:DAF-12_target_ALF4
			WBPaper00044656:tatn-1(qd182)_downregulated
			WBPaper00044736:flat_dev_expression
			WBPaper00044760:germline_specific
			WBPaper00045521:Oogenic
			WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
			WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
			WBPaper00048923:Aging_regulated
			WBPaper00048988:neuron_expressed
			WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
			WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
			WBPaper00049942:hsf-1(RNAi)_upregulated
			WBPaper00050344:AFD-neuron_enriched
			WBPaper00050344:PLM-neuron_enriched
			WBPaper00050488:adult_vs_dauer_regulated_N2_20C
			WBPaper00050522:mafr-1(tm6082)_downregulated
			WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
			WBPaper00050990:body-muscle_expressed
			WBPaper00050990:hypodermis_expressed
			WBPaper00050990:intestine_expressed
			WBPaper00051039:germline_enriched
			WBPaper00051265:F4_morc-1(tm6048)_upregulated
			WBPaper00052884:emb-4(hc60)_downregulated
			WBPaper00053184:sma-2(rax5)_downregulated
			WBPaper00053184:sma-4(rax3)_downregulated
			WBPaper00053289:DREAM-target
			WBPaper00053302:zidovudine_72h_regulated
			WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
			WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_L1_SMARTseq
			WBPaper00053321:PGCs_enriched_NuGen
			WBPaper00053599:female_vs_male_upregulated
			WBPaper00055354:eat-2(ad1116)_upregulated
			WBPaper00055354:Metformin_downregulated
			WBPaper00055354:Rapamycin-Allantoin_upregulated
			WBPaper00055354:Rapamycin_upregulated
			WBPaper00055354:Rifampicin_downregulated
			WBPaper00055482:pmt-2(RNAi)_downregulated
			WBPaper00055648:germline_expressed
			WBPaper00055827:pfd-6(gk493446)_upregulated
			WBPaper00055862:antimycin_damt-1(gk961032)_regulated
			WBPaper00056034:pals-22(jy3)_downregulated
			WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
			WBPaper00056139:soil-microbiota_downregulated
			WBPaper00056284:ints-5(RNAi)_downregulated
			WBPaper00056443:sek-1(km4)_downregulated
			WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
			WBPaper00057154:HeatShock_downregulated_mRNA
			WBPaper00057288:iff-1(RNAi)_upregulated_transcript
			WBPaper00058598:sin-3(tm1276)_upregulated
			WBPaper00058691:cfp-1(tm6369)_upregulated
			WBPaper00058691:sin-3(tm1276)_upregulated
			WBPaper00059174:MEG-3_interacting
			WBPaper00059471:EGL-43_interacting
			WBPaper00059664:srbc-48(ac23)_downregulated
			WBPaper00059763:neuron_expressed
			WBPaper00059824:rnp-6(dh1127)_regulated_OP50
			WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
			WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
			WBPaper00060683:hlh-11(ko1)_downregulated
			WBPaper00060909:atfs-1(cmh15)_upregulated
			WBPaper00061007:S.aquatilis_downregulated
			WBPaper00061203:let-418(n3536)_downregulated
			WBPaper00061203:sin-3(tm1276)_downregulated
			WBPaper00061203:spr-1(ok2144)_downregulated
			WBPaper00061340:g1A_parent
			WBPaper00061340:g2
			WBPaper00061439:unc-30(ok613)_downregulated
			WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
			WBPaper00061527:T02E1.2-uri-1
			WBPaper00062159:hda-2(ok1479)_downregulated
			WBPaper00062325:muscle_depleted_coding-RNA
			WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
			WBPaper00064716:paraquat_upregulated
			WBPaper00064871:hypoxia_upregulated_F2
			WBPaper00065096:25C_vs_20C_upregulated
			WBPaper00065096:Day10_vs_Day1_upregulated
			WBPaper00065993:glp-1(e2141)_downregulated
			WBPaper00066062:xrep-4(lax137)_upregulated
			WBPaper00066110:tetraploid_vs_diploid_downregulated
			WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
			cgc4489_group_2
			WBPaper00025032:cluster_1
			WBPaper00025141:N2_Expressed_Genes
			WBPaper00025141:unc-4::GFP_Expressed_Genes
			WBPaper00026929:sir-2.1_overexpression_regulated
			WBPaper00026980:intestine_enriched
			WBPaper00034739:N2moreDR1350
			WBPaper00035084:embryo_enriched_AIN-2_IP
			WBPaper00035873:dpy-9_regulated
			WBPaper00035873:dpy-10_regulated
			WBPaper00035905:FBF-1_Associated
			WBPaper00036130:mir-243_down_regulated
			WBPaper00036286:Pattern_F
			WBPaper00037147:heatshock_upregulated
			WBPaper00040963:TA300_down
			WBPaper00041002:HF_3d_0.2mM_Down
			WBPaper00041002:HF_3d_2.0mM_Down
			WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
			WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
			WBPaper00045263:0.1mM-paraquat_upregulated
			WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
			WBPaper00048989:N2_rapamycin_downregulated
			WBPaper00053236:Starvation_regulated_GR1307
			WBPaper00056330:mrps-5(RNAi)_downregulated
			[cgc5767]:cluster_1
			[cgc5767]:expression_class_M
			[cgc5767]:expression_class_MD
			[cgc5767]:expression_class_MD_pd(23_min)
			[cgc5767]:expression_class_SM
			[cgc5767]:expression_class_SMD
			[cgc6390]:Cluster_E
			[cgc6390]:oogenesis-enriched
		Interaction (104)
		WBProcess	WBbiopr:00000121
	Map_info	Map	III	Position	-2.57882	Error	0.009833
		Positive	Positive_clone	B0393	Inferred_automatically	From sequence, transcript, pseudogene data
		Mapping_data	Multi_point	5500
				4625
		Pseudo_map_position
	Reference	WBPaper00026147
		WBPaper00026699
		WBPaper00030935
		WBPaper00038491
		WBPaper00043173
		WBPaper00044609
		WBPaper00047687
		WBPaper00051758
		WBPaper00055090
	Remark	Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene