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WormBase Tree Display for Gene: WBGene00001228

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Name Class

WBGene00001228EvidencePerson_evidenceWBPerson599
SMapS_parentSequenceB0511
IdentityVersion1
NameCGC_nameeif-3.E
Sequence_nameB0511.10
Molecular_nameB0511.10
B0511.10.1
CE17349
Other_nameCELE_B0511.10Accession_evidenceNDBBX284601
Public_nameeif-3.E
DB_infoDatabaseAceViewgene1L218
WormQTLgeneWBGene00001228
WormFluxgeneWBGene00001228
NDBlocus_tagCELE_B0511.10
PanthergeneCAEEL|WormBase=WBGene00001228|UniProtKB=O61820
familyPTHR10317
NCBIgene172959
RefSeqproteinNM_060384.8
SwissProtUniProtAccO61820
TREEFAMTREEFAM_IDTF101518
UniProt_GCRPUniProtAccO61820
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:23WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classeif
Allele (24)
StrainWBStrain00036119
WBStrain00037023
RNASeq_FPKM (74)
GO_annotation (18)
Contained_in_operonCEOP1632
Ortholog (38)
Structured_descriptionConcise_descriptioneif-3.E encodes the C. elegans ortholog of the translation initiation factor 3 subunit e (eIF3e/Int-6); by homology, EIF-3.E is predicted to be a component of three different protein complexes, the eIF3 translation initiation factor, the 26S proteasome, and the COP9 signalosome; such association suggests that EIF-3.E may serve as a regulatory factor that coordinates the translational and degradative activities of these various complexes; in C. elegans, large-scale RNAi screens indicate that eif-3.E is required for embryonic, larval, and germline development, as well as proper vulval morphogenesis.Paper_evidenceWBPaper00004402
WBPaper00004651
WBPaper00006395
WBPaper00012836
WBPaper00013132
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionPredicted to enable translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in nucleus. Predicted to be part of eukaryotic translation initiation factor 3 complex. Expressed in head and tail. Is an ortholog of human EIF3E (eukaryotic translation initiation factor 3 subunit E).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSB0511.10
Corresponding_transcriptB0511.10.1
Other_sequence (80)
Associated_featureWBsf649587
WBsf220267
Experimental_infoRNAi_result (14)
Expr_patternChronogram1087
Expr5080
Expr1021518
Expr1030776
Expr1143295
Expr2011255
Expr2029491
Drives_constructWBCnstr00002198
WBCnstr00037024
Construct_productWBCnstr00037024
Microarray_results (20)
Expression_cluster (148)
Interaction (153)
Map_infoMapIPosition5.05967Error9.3e-05
PositivePositive_cloneB0511Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00027281
WBPaper00038491
WBPaper00049828
WBPaper00055090
WBPaper00064339
RemarkThe capital letters are used here to distinguish the different eIF3 subunit genes. This roughly agrees with worm gene nomenclature and it makes clear the orthologies for these universal factors (eif-3B corresponding to eIF3b, and so on), in the unified eIF3 nomenclature proposed by Browning KS et al (2001)[JAH][030106 ck1]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene