WormBase Tree Display for Gene: WBGene00000863

WBGene00000863 SMap: S_parent: Sequence: ZK507
  Identity: Version: 2
    Name: CGC_name: cya-1 Paper_evidence: WBPaper00002206
      Sequence_name: ZK507.6
      Molecular_name: ZK507.6
        ZK507.6.1
        CE03820
      Other_name: CELE_ZK507.6 Accession_evidence: NDB BX284603
      Public_name: cya-1
    DB_info: Database: WormFlux gene WBGene00000863
        NDB locus_tag CELE_ZK507.6
        Panther gene CAEEL|WormBase=WBGene00000863|UniProtKB=P34638
          family PTHR10177
        NCBI gene 176287
        RefSeq protein NM_066617.10
        SwissProt UniProtAcc P34638
        TREEFAM TREEFAM_ID TF101002
        UniProt_GCRP UniProtAcc P34638
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 01 May 2012 15:45:01 WBPerson2970 Event: Acquires_merge: WBGene00013981
              Name_change: Sequence_name: ZK507.6
      Acquires_merge: WBGene00013981
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cya
    Allele (35)
    Legacy_information: [C.elegansII] NMK. Encodes predicted cyclin A. [KB]
    Strain: WBStrain00054800
    RNASeq_FPKM (74)
    GO_annotation (12)
    Ortholog (49)
    Paralog (13)
    Structured_description: Concise_description: cya-1 encodes an A-type cyclin; loss of cya-1 via RNAi results in sterility but no defects in embryonic cell divisions, or embryonic lethality, is observed; CYA-1 is predicted to be a substrate of germ-line MPK-1/ERK activity that functions to regulate oocyte organization and differentiation. Paper_evidence: WBPaper00002206
            WBPaper00032961
            WBPaper00035305
          Curator_confirmed: WBPerson1843
          Date_last_updated: 19 Apr 2010 00:00:00
      Automated_description: Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Involved in meiotic cell cycle. Predicted to be located in cytoplasm and nucleus. Predicted to be part of cyclin A2-CDK2 complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia; embryonal carcinoma; and prostate cancer. Is an ortholog of human CCNA1 (cyclin A1) and CCNA2 (cyclin A2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10283 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1577)
      DOID:3308 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1578)
      DOID:9119 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1577)
  Molecular_info: Corresponding_CDS: ZK507.6
    Corresponding_transcript: ZK507.6.1
    Other_sequence (17)
    Associated_feature: WBsf655464
      WBsf993573
      WBsf993574
      WBsf993575
      WBsf1015545
      WBsf1015546
      WBsf227245
      WBsf227246
  Experimental_info: RNAi_result: WBRNAi00006081 Inferred_automatically: RNAi_primary
      WBRNAi00111768 Inferred_automatically: RNAi_primary
      WBRNAi00059467 Inferred_automatically: RNAi_primary
      WBRNAi00022037 Inferred_automatically: RNAi_primary
      WBRNAi00007172 Inferred_automatically: RNAi_primary
      WBRNAi00061963 Inferred_automatically: RNAi_primary
      WBRNAi00022036 Inferred_automatically: RNAi_primary
      WBRNAi00027640 Inferred_automatically: RNAi_primary
      WBRNAi00059468 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1030531
      Expr1162890
      Expr2010644
      Expr2028884
    Drives_construct: WBCnstr00037240
    Construct_product: WBCnstr00037240
    Microarray_results (18)
    Expression_cluster (147)
    Interaction: WBInteraction000520790
      WBInteraction000521994
      WBInteraction000524377
      WBInteraction000548871
  Map_info: Map: III Position: 0.164672
    Positive: Positive_clone: KB#L2E
        ZK507 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (16)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene