cya-1 encodes an A-type cyclin; loss of cya-1 via RNAi results in sterility but no defects in embryonic cell divisions, or embryonic lethality, is observed; CYA-1 is predicted to be a substrate of germ-line MPK-1/ERK activity that functions to regulate oocyte organization and differentiation.
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Involved in meiotic cell cycle. Predicted to be located in cytoplasm and nucleus. Predicted to be part of cyclin A2-CDK2 complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia; embryonal carcinoma; and prostate cancer. Is an ortholog of human CCNA1 (cyclin A1) and CCNA2 (cyclin A2).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.