WormBase Tree Display for Gene: WBGene00022473
expand all nodes | collapse all nodes | view schema
| WBGene00022473 | SMap | S_parent | Sequence | Y119C1B | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | bet-1 | Person_evidence | WBPerson552 | |||||
| WBPerson2693 | |||||||||
| Sequence_name | Y119C1B.8 | ||||||||
| Molecular_name (24) | |||||||||
| Other_name | tag-332 | ||||||||
| Y119C1B.d | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_Y119C1B.8 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | bet-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:05 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 22 Apr 2005 11:55:18 | WBPerson2970 | Name_change | CGC_name | tag-332 | ||||
| 3 | 04 Feb 2010 10:00:26 | WBPerson2970 | Name_change | CGC_name | bet-1 | ||||
| Other_name | tag-332 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | bet | ||||||||
| Allele (136) | |||||||||
| Strain | WBStrain00001175 | ||||||||
| WBStrain00036275 | |||||||||
| WBStrain00008481 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (33) | |||||||||
| Ortholog (48) | |||||||||
| Paralog | WBGene00017423 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00001470 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00009180 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00010199 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00019217 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00021636 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | bet-1 encodes a BET-family protein that colocalizes with chromosomes; Bet-family proteins are evolutionarily conserved, have two bromodomains, which recognize acetylated histone; BET-1 functions cell-autonomously; in bet-1 mutants, asymmetry of T-cell division is initially normal but later disrupted, BET-1 regulates the expression of cell-fate determinants, such as MEC-3, to prevent the excessive production of certain types of cells; BET-1 is required for cell-fate maintenance after the acquisition of cell fate; MYS-1 and MYS-2 histone acetyltransferases (HATs) function in the BET-1-mediated maintenance of cell fates, via sub-nuclear localization of BET-1; bet-1::GFP expression is granular in nuclei and esp along the metaphase plate during division, indicating the BET-1::GFP colocalized with chromosomes at mitosis in most of the cells including the T, V5.pa Z1/Z4 and Q cells and all their descendents. | Paper_evidence | WBPaper00036007 | |||||
| Curator_confirmed | WBPerson12884 | ||||||||
| Date_last_updated | 17 May 2011 00:00:00 | ||||||||
| Automated_description | Enables SUMO binding activity and lysine-acetylated histone binding activity. Involved in several processes, including multicellular organismal locomotion; muscle cell cellular homeostasis; and regulation of DNA-templated transcription. Located in chromosome; metaphase plate; and nucleus. Expressed in several structures, including hypodermal cell and seam cell. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); lymphoma (multiple); and male infertility (multiple). Is an ortholog of human BRD2 (bromodomain containing 2) and BRDT (bromodomain testis associated). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (13) | ||||||||
| Molecular_info | Corresponding_CDS | Y119C1B.8a | |||||||
| Y119C1B.8b | |||||||||
| Y119C1B.8c | |||||||||
| Y119C1B.8d | |||||||||
| Y119C1B.8e | |||||||||
| Y119C1B.8f | |||||||||
| Y119C1B.8g | |||||||||
| Y119C1B.8h | |||||||||
| Corresponding_CDS_history | Y119C1B.8a:wp191 | ||||||||
| Y119C1B.8a:wp205 | |||||||||
| Y119C1B.8b:wp274 | |||||||||
| Corresponding_transcript | Y119C1B.8a.1 | ||||||||
| Y119C1B.8b.1 | |||||||||
| Y119C1B.8c.1 | |||||||||
| Y119C1B.8d.1 | |||||||||
| Y119C1B.8e.1 | |||||||||
| Y119C1B.8f.1 | |||||||||
| Y119C1B.8g.1 | |||||||||
| Y119C1B.8h.1 | |||||||||
| Other_sequence | FG349447.1 | ||||||||
| CBC02306_1 | |||||||||
| JI166871.1 | |||||||||
| CR00543 | |||||||||
| TSC00458_1 | |||||||||
| FG352149.1 | |||||||||
| CRC00284_1 | |||||||||
| CBC11430_1 | |||||||||
| CBC04665_1 | |||||||||
| PT04631 | |||||||||
| Associated_feature (14) | |||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern | Chronogram1674 | ||||||||
| Expr6895 | |||||||||
| Expr9002 | |||||||||
| Expr1013684 | |||||||||
| Expr1039933 | |||||||||
| Expr1159004 | |||||||||
| Expr2009615 | |||||||||
| Expr2027853 | |||||||||
| Drives_construct | WBCnstr00002067 | ||||||||
| WBCnstr00013667 | |||||||||
| WBCnstr00016101 | |||||||||
| WBCnstr00037820 | |||||||||
| WBCnstr00042923 | |||||||||
| Construct_product | WBCnstr00013667 | ||||||||
| WBCnstr00016101 | |||||||||
| WBCnstr00037820 | |||||||||
| WBCnstr00042923 | |||||||||
| Regulate_expr_cluster | WBPaper00064735:bet-1(RNAi)_vs_N2_downregulated | ||||||||
| WBPaper00064735:bet-1(RNAi)_vs_N2_upregulated | |||||||||
| WBPaper00064735:bet-1(uth41)_vs_N2_downregulated | |||||||||
| WBPaper00064735:bet-1(uth41)_vs_N2_upregulated | |||||||||
| WBPaper00064735:bet-1B(OE)mys-1(RNAi)_vs_mys-1(RNAi)_downregulated | |||||||||
| WBPaper00064735:bet-1B(OE)mys-1(RNAi)_vs_mys-1(RNAi)_upregulated | |||||||||
| WBPaper00064735:bet-1B(OE)_vs_N2_downregulated | |||||||||
| WBPaper00064735:bet-1B(OE)_vs_N2_upregulated | |||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (111) | |||||||||
| Interaction (119) | |||||||||
| Anatomy_function | WBbtf0428 | ||||||||
| Map_info | Map | I | Position | -1.05961 | Error | 0.023716 | |||
| Positive | Positive_clone | Y119C1B | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5127 | |||||||
| 4204 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (20) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
