WormBase Tree Display for Gene: WBGene00006349
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| WBGene00006349 | SMap | S_parent | Sequence | F39B2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | sur-2 | Person_evidence | WBPerson237 | |||||
| Sequence_name | F39B2.4 | ||||||||
| Molecular_name | F39B2.4a | ||||||||
| F39B2.4a.1 | |||||||||
| CE28023 | |||||||||
| F39B2.4b | |||||||||
| CE28024 | |||||||||
| F39B2.4b.1 | |||||||||
| Other_name | mdt-23 | Author_evidence | Bourbon H-M | ||||||
| CELE_F39B2.4 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | sur-2 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sur | ||||||||
| Allele (231) | |||||||||
| Legacy_information | [Singh N, Han M] all alleles are 100% Egl and defective in vulval cell differentiation | ||||||||
| [C.elegansII] ku9 : suppressor of let-60(gf); pleiotropic effects, some gonadal abnormality, vulval defects, larval lethality, Egl, male tail defects; ku9/Df stronger Vul phenotype. OA7: ku9, ku31, ku42, ku115amb (all similar to ku9; all nonsense mutations), ku60 (Egl non-Vul) etc. Cloned: 5kb transcript, enriched in embryo and early larva; encodes predicted 1586 aa novel protein. sur-2:lacZ expressed in VPC during vulval differentiation. [Singh and Han 1995; MH] | |||||||||
| Strain | WBStrain00026495 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00056714 | ||||||||
| 00056715 | |||||||||
| 00056716 | |||||||||
| 00056717 | |||||||||
| 00056718 | |||||||||
| 00056719 | |||||||||
| 00056720 | |||||||||
| 00056721 | |||||||||
| 00056722 | |||||||||
| 00056723 | |||||||||
| Contained_in_operon | CEOP1760 | ||||||||
| Ortholog (41) | |||||||||
| Structured_description | Concise_description | sur-2 encodes a novel protein that is orthologous to the Drosophila and human MED23 mediator subunits; sur-2 is a downstream component of the let-60-ras-mediated signaling pathway and likely functions by regulating transcription of genes essential for a number of developmental processes, including vulval development, larval development, and formation of the gonad and male tail; sur-2 is expressed in all Pn.p cells from the mid-L1 through the L3 larval stage, and then in the vulval precursor cells as they divide, with strongest staining observed in the primary and secondary lineages; sur-2 is also expressed in embryonic and other larval stage cells, including the distal tip cells of the gonad. | Paper_evidence | WBPaper00002286 | |||||
| WBPaper00006530 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 30 Aug 2006 00:00:00 | ||||||||
| Automated_description | Involved in defense response to Gram-positive bacterium; regulation of protein catabolic process; and regulation of transcription by RNA polymerase II. Part of mediator complex. Expressed in several structures, including P1.p; P2.p; P5.ppp; P7.paa; and vulval cell. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 18. Is an ortholog of human MED23 (mediator complex subunit 23). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0081190 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2372) | ||||
| Molecular_info | Corresponding_CDS | F39B2.4a | |||||||
| F39B2.4b | |||||||||
| Corresponding_CDS_history | F39B2.4a:wp52 | ||||||||
| F39B2.4b:wp52 | |||||||||
| Corresponding_transcript | F39B2.4a.1 | ||||||||
| F39B2.4b.1 | |||||||||
| Other_sequence (14) | |||||||||
| Associated_feature | WBsf649777 | ||||||||
| WBsf220654 | |||||||||
| WBsf220655 | |||||||||
| Transcription_factor | WBTranscriptionFactor000623 | ||||||||
| Experimental_info | RNAi_result (19) | ||||||||
| Expr_pattern | Expr1555 | ||||||||
| Expr1014742 | |||||||||
| Expr1032557 | |||||||||
| Expr1150631 | |||||||||
| Expr2017135 | |||||||||
| Expr2035271 | |||||||||
| Drives_construct | WBCnstr00000267 | ||||||||
| WBCnstr00006728 | |||||||||
| WBCnstr00006816 | |||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (106) | |||||||||
| Interaction (82) | |||||||||
| WBProcess | WBbiopr:00000039 | ||||||||
| Map_info | Map | I | Position | 26.8242 | Error | 0.023687 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F39B2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 2220 | |||||||
| 2221 | |||||||||
| 2222 | |||||||||
| 4409 | |||||||||
| Pos_neg_data | 6701 | ||||||||
| 6702 | |||||||||
| 6703 | |||||||||
| 6704 | |||||||||
| 6705 | |||||||||
| 6706 | |||||||||
| Reference (79) | |||||||||
| Method | Gene |
