WormBase Tree Display for Gene: WBGene00006349
expand all nodes | collapse all nodes | view schema
WBGene00006349 | SMap | S_parent | Sequence | F39B2 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | sur-2 | Person_evidence | WBPerson237 | |||||
Sequence_name | F39B2.4 | ||||||||
Molecular_name | F39B2.4a | ||||||||
F39B2.4a.1 | |||||||||
CE28023 | |||||||||
F39B2.4b | |||||||||
CE28024 | |||||||||
F39B2.4b.1 | |||||||||
Other_name | mdt-23 | Author_evidence | Bourbon H-M | ||||||
CELE_F39B2.4 | Accession_evidence | NDB | BX284601 | ||||||
Public_name | sur-2 | ||||||||
DB_info | Database (12) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | sur | ||||||||
Allele (231) | |||||||||
Legacy_information | [Singh N, Han M] all alleles are 100% Egl and defective in vulval cell differentiation | ||||||||
[C.elegansII] ku9 : suppressor of let-60(gf); pleiotropic effects, some gonadal abnormality, vulval defects, larval lethality, Egl, male tail defects; ku9/Df stronger Vul phenotype. OA7: ku9, ku31, ku42, ku115amb (all similar to ku9; all nonsense mutations), ku60 (Egl non-Vul) etc. Cloned: 5kb transcript, enriched in embryo and early larva; encodes predicted 1586 aa novel protein. sur-2:lacZ expressed in VPC during vulval differentiation. [Singh and Han 1995; MH] | |||||||||
Strain | WBStrain00026495 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation | 00056714 | ||||||||
00056715 | |||||||||
00056716 | |||||||||
00056717 | |||||||||
00056718 | |||||||||
00056719 | |||||||||
00056720 | |||||||||
00056721 | |||||||||
00056722 | |||||||||
00056723 | |||||||||
Contained_in_operon | CEOP1760 | ||||||||
Ortholog (41) | |||||||||
Structured_description | Concise_description | sur-2 encodes a novel protein that is orthologous to the Drosophila and human MED23 mediator subunits; sur-2 is a downstream component of the let-60-ras-mediated signaling pathway and likely functions by regulating transcription of genes essential for a number of developmental processes, including vulval development, larval development, and formation of the gonad and male tail; sur-2 is expressed in all Pn.p cells from the mid-L1 through the L3 larval stage, and then in the vulval precursor cells as they divide, with strongest staining observed in the primary and secondary lineages; sur-2 is also expressed in embryonic and other larval stage cells, including the distal tip cells of the gonad. | Paper_evidence | WBPaper00002286 | |||||
WBPaper00006530 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 30 Aug 2006 00:00:00 | ||||||||
Automated_description | Involved in defense response to Gram-positive bacterium; regulation of protein catabolic process; and regulation of transcription by RNA polymerase II. Part of mediator complex. Expressed in several structures, including P1.p; P2.p; P5.ppp; P7.paa; and vulval cell. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 18. Is an ortholog of human MED23 (mediator complex subunit 23). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:0081190 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2372) | ||||
Molecular_info (6) | |||||||||
Experimental_info | RNAi_result (19) | ||||||||
Expr_pattern | Expr1555 | ||||||||
Expr1014742 | |||||||||
Expr1032557 | |||||||||
Expr1150631 | |||||||||
Expr2017135 | |||||||||
Expr2035271 | |||||||||
Drives_construct | WBCnstr00000267 | ||||||||
WBCnstr00006728 | |||||||||
WBCnstr00006816 | |||||||||
Microarray_results (25) | |||||||||
Expression_cluster (106) | |||||||||
Interaction (82) | |||||||||
WBProcess | WBbiopr:00000039 | ||||||||
Map_info | Map | I | Position | 26.8242 | Error | 0.023687 | |||
Well_ordered | |||||||||
Positive | Positive_clone | F39B2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 2220 | |||||||
2221 | |||||||||
2222 | |||||||||
4409 | |||||||||
Pos_neg_data | 6701 | ||||||||
6702 | |||||||||
6703 | |||||||||
6704 | |||||||||
6705 | |||||||||
6706 | |||||||||
Reference (79) | |||||||||
Method | Gene |