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WormBase Tree Display for Gene: WBGene00006349

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Name Class

WBGene00006349SMapS_parentSequenceF39B2
IdentityVersion1
NameCGC_namesur-2Person_evidenceWBPerson237
Sequence_nameF39B2.4
Molecular_nameF39B2.4a
F39B2.4a.1
CE28023
F39B2.4b
CE28024
F39B2.4b.1
Other_namemdt-23Author_evidenceBourbon H-M
CELE_F39B2.4Accession_evidenceNDBBX284601
Public_namesur-2
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:40WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classsur
AlleleWBVar02148914
WBVar00278508
WBVar00088301
WBVar00088309
WBVar01473867
WBVar00353220
WBVar00693915
WBVar00162533
WBVar00693916
WBVar00162534
WBVar00353221
WBVar01357279
WBVar00693917
WBVar00162535
WBVar01231767
WBVar00353222
WBVar01357290
WBVar00162536
WBVar00353223
WBVar00693918
WBVar01231768
WBVar01357301
WBVar00353224
WBVar00162537
WBVar00693919
WBVar01231769
WBVar00693920
WBVar01820993
WBVar01231770
WBVar00162538
WBVar00353225
WBVar00353226
WBVar00693921
WBVar00162539
WBVar01231771
WBVar00693922
WBVar01231773
WBVar00353227
WBVar00693923
WBVar00353228
WBVar00353229
WBVar01231776
WBVar00298087
WBVar00693924
WBVar00353230
WBVar00693925
WBVar01231778
WBVar00353231
WBVar01231779
WBVar00693926
WBVar02108462
WBVar00353232
WBVar01231780
WBVar01236285
WBVar00693927
WBVar00693928
WBVar01231781
WBVar00353233
WBVar01231782
WBVar00693929
WBVar01236296
WBVar00353234
WBVar01231783
WBVar00693930
WBVar00353235
WBVar01231784
WBVar01557747
WBVar00693931
WBVar00353236
WBVar00693932
WBVar00353237
WBVar01557748
WBVar01236307
WBVar01476717
WBVar00693933
WBVar00353238
WBVar01231787
WBVar01557749
WBVar00693934
WBVar01476718
WBVar01231788
WBVar01557750
WBVar00353239
WBVar00693935
WBVar00353240
WBVar01231789
WBVar01236318
WBVar01557751
WBVar01231790
WBVar00353241
WBVar01557752
WBVar00693936
WBVar01231791
WBVar00693937
WBVar01236329
WBVar00543253
WBVar00693938
WBVar01231792
WBVar01499908
WBVar01231793
WBVar00543254
WBVar00693939
WBVar00543258
WBVar01231794
WBVar01574564
WBVar00693940
WBVar00693941
WBVar01236340
WBVar00693942
WBVar01231798
WBVar00693943
WBVar00693944
WBVar00693945
WBVar00693946
WBVar00693947
WBVar02066910
WBVar00693948
WBVar00693949
WBVar02080699
WBVar00693950
WBVar00693951
WBVar00693952
WBVar02011381
WBVar00693953
WBVar01788758
WBVar01499739
WBVar00693954
WBVar00693955
WBVar00693956
WBVar02017099
WBVar02017100
WBVar02017101
WBVar02017102
WBVar02050814
WBVar01958859
WBVar01958860
WBVar01958862
WBVar00214004
WBVar01502704
WBVar01502705
WBVar01502706
WBVar01502707
WBVar02114590
WBVar01502708
WBVar01502709
WBVar01502710
WBVar01502711
WBVar01502712
WBVar01494435
WBVar01715218
WBVar01715219
WBVar01715220
WBVar02088858
WBVar01622961
WBVar01910389
WBVar01993816
WBVar01499627
WBVar01499628
WBVar02069229
WBVar01499999
WBVar01392855
WBVar00144937
WBVar01392857
WBVar02049405
WBVar01392858
WBVar02102682
WBVar01499823
WBVar00088296
WBVar00088298
WBVar01846535
WBVar01846536
WBVar01357040
WBVar02151201
WBVar01357050
WBVar02075788
WBVar01641490
WBVar01499298
WBVar01641491
WBVar01948638
WBVar01948639
WBVar01948640
WBVar01948641
WBVar00693889
WBVar00693890
WBVar01498939
WBVar00693891
WBVar00693892
WBVar00693893
WBVar00693894
WBVar01404191
WBVar00693895
WBVar01404192
WBVar00693896
WBVar01404193
WBVar01404194
WBVar00693897
WBVar01404195
WBVar00693898
WBVar01404196
WBVar00693899
WBVar01404197
WBVar00693900
WBVar00693901
WBVar00693902
WBVar00693903
WBVar00693904
WBVar00162522
WBVar00162523
WBVar00693905
WBVar00162524
WBVar00693906
WBVar00162525
WBVar00693907
WBVar00693908
WBVar00162526
WBVar02070593
WBVar00693909
WBVar00162527
WBVar02070594
WBVar00162528
WBVar00693910
WBVar00693911
WBVar00162529
WBVar01435069
WBVar00693912
WBVar00162530
WBVar01435070
WBVar00162531
WBVar00693913
WBVar00693914
WBVar00162532
Legacy_information[Singh N, Han M] all alleles are 100% Egl and defective in vulval cell differentiation
[C.elegansII] ku9 : suppressor of let-60(gf); pleiotropic effects, some gonadal abnormality, vulval defects, larval lethality, Egl, male tail defects; ku9/Df stronger Vul phenotype. OA7: ku9, ku31, ku42, ku115amb (all similar to ku9; all nonsense mutations), ku60 (Egl non-Vul) etc. Cloned: 5kb transcript, enriched in embryo and early larva; encodes predicted 1586 aa novel protein. sur-2:lacZ expressed in VPC during vulval differentiation. [Singh and Han 1995; MH]
StrainWBStrain00026495
RNASeq_FPKM (74)
GO_annotation00056714
00056715
00056716
00056717
00056718
00056719
00056720
00056721
00056722
00056723
Contained_in_operonCEOP1760
Ortholog (41)
Structured_descriptionConcise_descriptionsur-2 encodes a novel protein that is orthologous to the Drosophila and human MED23 mediator subunits; sur-2 is a downstream component of the let-60-ras-mediated signaling pathway and likely functions by regulating transcription of genes essential for a number of developmental processes, including vulval development, larval development, and formation of the gonad and male tail; sur-2 is expressed in all Pn.p cells from the mid-L1 through the L3 larval stage, and then in the vulval precursor cells as they divide, with strongest staining observed in the primary and secondary lineages; sur-2 is also expressed in embryonic and other larval stage cells, including the distal tip cells of the gonad.Paper_evidenceWBPaper00002286
WBPaper00006530
Curator_confirmedWBPerson1843
Date_last_updated30 Aug 2006 00:00:00
Automated_descriptionInvolved in defense response to Gram-positive bacterium; regulation of protein catabolic process; and regulation of transcription by RNA polymerase II. Part of mediator complex. Expressed in several structures, including P1.p; P2.p; P5.ppp; P7.paa; and vulval cell. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 18. Is an ortholog of human MED23 (mediator complex subunit 23).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0081190Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2372)
Molecular_infoCorresponding_CDSF39B2.4a
F39B2.4b
Corresponding_CDS_historyF39B2.4a:wp52
F39B2.4b:wp52
Corresponding_transcriptF39B2.4a.1
F39B2.4b.1
Other_sequence (14)
Associated_featureWBsf649777
WBsf220654
WBsf220655
Transcription_factorWBTranscriptionFactor000623
Experimental_infoRNAi_result (19)
Expr_patternExpr1555
Expr1014742
Expr1032557
Expr1150631
Expr2017135
Expr2035271
Drives_constructWBCnstr00000267
WBCnstr00006728
WBCnstr00006816
Microarray_results (25)
Expression_cluster (106)
Interaction (82)
WBProcessWBbiopr:00000039
Map_infoMapIPosition26.8242Error0.023687
Well_ordered
PositivePositive_cloneF39B2Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point2220
2221
2222
4409
Pos_neg_data6701
6702
6703
6704
6705
6706
Reference (79)
MethodGene