WormBase Tree Display for Gene: WBGene00006349
expand all nodes | collapse all nodes | view schema
WBGene00006349 | SMap | S_parent | Sequence | F39B2 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | sur | ||||||
Allele (231) | |||||||
Legacy_information | [Singh N, Han M] all alleles are 100% Egl and defective in vulval cell differentiation | ||||||
[C.elegansII] ku9 : suppressor of let-60(gf); pleiotropic effects, some gonadal abnormality, vulval defects, larval lethality, Egl, male tail defects; ku9/Df stronger Vul phenotype. OA7: ku9, ku31, ku42, ku115amb (all similar to ku9; all nonsense mutations), ku60 (Egl non-Vul) etc. Cloned: 5kb transcript, enriched in embryo and early larva; encodes predicted 1586 aa novel protein. sur-2:lacZ expressed in VPC during vulval differentiation. [Singh and Han 1995; MH] | |||||||
Strain | WBStrain00026495 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00056714 | ||||||
00056715 | |||||||
00056716 | |||||||
00056717 | |||||||
00056718 | |||||||
00056719 | |||||||
00056720 | |||||||
00056721 | |||||||
00056722 | |||||||
00056723 | |||||||
Contained_in_operon | CEOP1760 | ||||||
Ortholog (41) | |||||||
Structured_description | Concise_description | sur-2 encodes a novel protein that is orthologous to the Drosophila and human MED23 mediator subunits; sur-2 is a downstream component of the let-60-ras-mediated signaling pathway and likely functions by regulating transcription of genes essential for a number of developmental processes, including vulval development, larval development, and formation of the gonad and male tail; sur-2 is expressed in all Pn.p cells from the mid-L1 through the L3 larval stage, and then in the vulval precursor cells as they divide, with strongest staining observed in the primary and secondary lineages; sur-2 is also expressed in embryonic and other larval stage cells, including the distal tip cells of the gonad. | Paper_evidence | WBPaper00002286 | |||
WBPaper00006530 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 30 Aug 2006 00:00:00 | ||||||
Automated_description | Involved in defense response to Gram-positive bacterium; regulation of protein catabolic process; and regulation of transcription by RNA polymerase II. Part of mediator complex. Expressed in several structures, including P1.p; P2.p; P5.ppp; P7.paa; and vulval cell. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 18. Is an ortholog of human MED23 (mediator complex subunit 23). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0081190 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2372) | ||
Molecular_info | Corresponding_CDS | F39B2.4a | |||||
F39B2.4b | |||||||
Corresponding_CDS_history | F39B2.4a:wp52 | ||||||
F39B2.4b:wp52 | |||||||
Corresponding_transcript | F39B2.4a.1 | ||||||
F39B2.4b.1 | |||||||
Other_sequence (14) | |||||||
Associated_feature | WBsf649777 | ||||||
WBsf220654 | |||||||
WBsf220655 | |||||||
Transcription_factor | WBTranscriptionFactor000623 | ||||||
Experimental_info | RNAi_result (19) | ||||||
Expr_pattern | Expr1555 | ||||||
Expr1014742 | |||||||
Expr1032557 | |||||||
Expr1150631 | |||||||
Expr2017135 | |||||||
Expr2035271 | |||||||
Drives_construct | WBCnstr00000267 | ||||||
WBCnstr00006728 | |||||||
WBCnstr00006816 | |||||||
Microarray_results (25) | |||||||
Expression_cluster (106) | |||||||
Interaction (82) | |||||||
WBProcess | WBbiopr:00000039 | ||||||
Map_info | Map | I | Position | 26.8242 | Error | 0.023687 | |
Well_ordered | |||||||
Positive | Positive_clone | F39B2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 2220 | |||||
2221 | |||||||
2222 | |||||||
4409 | |||||||
Pos_neg_data | 6701 | ||||||
6702 | |||||||
6703 | |||||||
6704 | |||||||
6705 | |||||||
6706 | |||||||
Reference (79) | |||||||
Method | Gene |