WormBase Tree Display for Gene: WBGene00004888
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| WBGene00004888 | SMap | S_parent | Sequence | K12C11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | smo-1 | |||||||
| Sequence_name | K12C11.2 | ||||||||
| Molecular_name | K12C11.2 | ||||||||
| K12C11.2.1 | |||||||||
| CE18056 | |||||||||
| Other_name | SMT3 | Accession_evidence | EMBL | X99600 | |||||
| U94830 | |||||||||
| K12C11.f | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_K12C11.2 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | smo-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | smo | ||||||||
| Allele (11) | |||||||||
| Strain | WBStrain00003532 | ||||||||
| WBStrain00024026 | |||||||||
| WBStrain00024025 | |||||||||
| WBStrain00035570 | |||||||||
| WBStrain00050864 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (56) | |||||||||
| Ortholog (38) | |||||||||
| Structured_description | Concise_description | smo-1 encodes the C. elegans ortholog of SUMO, a small ubiquitin-like moiety that, when attached to protein substrates, regulates their subcellular localization and activity; smo-1 is an essential gene: loss of its activity results in embryonic and larval lethality; in addition, smo-1 mutants have defects in synaptonemal complex disassembly and bivalent formation, enhance meiotic defects of zhp-3::gfp mutants and show mislocalization of ZHP-3 in late pachytene; smo-1 is also required for reproductive system development, where its target may be the LIN-11 LIM homeodomain protein. | Paper_evidence | WBPaper00006514 | |||||
| WBPaper00024467 | |||||||||
| WBPaper00032296 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 18 Feb 2009 00:00:00 | ||||||||
| Automated_description | Enables identical protein binding activity. Involved in several processes, including chromosome organization; multicellular organismal locomotion; and muscle cell cellular homeostasis. Predicted to be located in PML body. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; hermaphrodite somatic gonadal cell; and ventral nerve cord. Human ortholog(s) of this gene implicated in orofacial cleft 10. Is an ortholog of human SUMO1P1 (SUMO1 pseudogene 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0080403 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12502) | ||||
| Molecular_info | Corresponding_CDS | K12C11.2 | |||||||
| Corresponding_transcript | K12C11.2.1 | ||||||||
| Other_sequence (104) | |||||||||
| Associated_feature | WBsf643048 | ||||||||
| WBsf643049 | |||||||||
| WBsf655912 | |||||||||
| WBsf655913 | |||||||||
| WBsf217207 | |||||||||
| WBsf217208 | |||||||||
| WBsf217209 | |||||||||
| Experimental_info | RNAi_result (91) | ||||||||
| Expr_pattern | Chronogram603 | ||||||||
| Expr3449 | |||||||||
| Expr6394 | |||||||||
| Expr13766 | |||||||||
| Expr13970 | |||||||||
| Expr1020726 | |||||||||
| Expr1032427 | |||||||||
| Expr1154360 | |||||||||
| Expr2015921 | |||||||||
| Expr2034154 | |||||||||
| Drives_construct | WBCnstr00000619 | ||||||||
| WBCnstr00003986 | |||||||||
| Construct_product | WBCnstr00019665 | ||||||||
| WBCnstr00019666 | |||||||||
| WBCnstr00019667 | |||||||||
| WBCnstr00019668 | |||||||||
| WBCnstr00019958 | |||||||||
| WBCnstr00019987 | |||||||||
| WBCnstr00020940 | |||||||||
| Regulate_expr_cluster | WBPaper00053615:SMO-1_target | ||||||||
| WBPaper00061478:SUMO-conjugated_protein | |||||||||
| Antibody | WBAntibody00002602 | ||||||||
| WBAntibody00002603 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (164) | |||||||||
| Interaction (2856) | |||||||||
| Map_info | Map | I | Position | -14.6998 | Error | 0.008159 | |||
| Positive | Positive_clone | K12C11 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4668 | |||||||
| Pseudo_map_position | |||||||||
| Reference (56) | |||||||||
| Remark | Sequence connection from [Leight L] 02/06/10 krb | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
