WormBase Tree Display for Gene: WBGene00004302

WBGene00004302 SMap: S_parent: Sequence: K01G5
  Identity: Version: 1
    Name: CGC_name: ran-1
      Sequence_name: K01G5.4
      Molecular_name: K01G5.4
        K01G5.4.1
        CE16194
      Other_name: CELE_K01G5.4 Accession_evidence: NDB BX284603
      Public_name: ran-1
    DB_info: Database: AceView gene 3L836
        WormQTL gene WBGene00004302
        WormFlux gene WBGene00004302
        NDB locus_tag CELE_K01G5.4
        Panther gene CAEEL|WormBase=WBGene00004302|UniProtKB=O17915
          family PTHR24071
        NCBI gene 176503
        RefSeq protein NM_066968.8
        SwissProt UniProtAcc O17915
        TREEFAM TREEFAM_ID TF106302
        UniProt_GCRP UniProtAcc O17915
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:34 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ran
    Allele (19)
    RNASeq_FPKM (74)
    GO_annotation (23)
    Ortholog (43)
    Structured_description: Concise_description: ran-1 encodes the C. elegans Ran GTPase ortholog; ran-1 activity is essential for proper mitotic spindle formation, effective connection between centrosomes and the male pronucleus, nuclear envelope assembly after cell division, and oocyte meiotic maturation; in regulating nuclear envelope dynamics, ran-1 appears to function upstream of MEL-28 by regulating its localization to the nuclear periphery; in regulating oocyte meiotic maturation, RAN-1 interacts with VAB-1 MSP/Eph and regulates its localization to endocytic-recycling vesicles in the absence of the major sperm protein (MSP)/sperm; in dissected gonads and oocytes, RAN-1 staining is detected at the cortex. Paper_evidence: WBPaper00005637
            WBPaper00028457
            WBPaper00031867
          Curator_confirmed: WBPerson1843
          Date_last_updated: 13 May 2008 00:00:00
      Automated_description: Predicted to enable GTPase activity. Involved in embryo development and oogenesis. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Is an ortholog of human RAN (RAN, member RAS oncogene family). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9744 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9846)
  Molecular_info: Corresponding_CDS: K01G5.4
    Corresponding_transcript: K01G5.4.1
    Other_sequence (143)
    Associated_feature (16)
  Experimental_info: RNAi_result (30)
    Expr_pattern: Expr11867
      Expr1017913
      Expr1032127
      Expr1153362
      Expr2015250
      Expr2033484
    Drives_construct: WBCnstr00035579
    Construct_product: WBCnstr00035579
    Microarray_results (25)
    Expression_cluster (217)
    Interaction (481)
    WBProcess: WBbiopr:00000120
  Map_info: Map: III Position: 5.17476 Error: 0.025579
    Positive: Positive_clone: K01G5 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (24)
  Remark: Sequence connection from [Askjaer P, Mattaj IW]. krb 13/11/01
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene