WormBase Tree Display for Gene: WBGene00004272
expand all nodes | collapse all nodes | view schema
| WBGene00004272 | SMap | S_parent | Sequence | D1037 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | rab-8 | Person_evidence | WBPerson451 | |||||
| Sequence_name | D1037.4 | ||||||||
| Molecular_name | D1037.4 | ||||||||
| D1037.4.1 | |||||||||
| CE30373 | |||||||||
| Other_name | rab8 | Accession_evidence | EMBL | AB112929 | |||||
| CELE_D1037.4 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | rab-8 | ||||||||
| DB_info | Database | AceView | gene | 1E252 | |||||
| WormQTL | gene | WBGene00004272 | |||||||
| WormFlux | gene | WBGene00004272 | |||||||
| NDB | locus_tag | CELE_D1037.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004272|UniProtKB=G5EFC1 | |||||||
| family | PTHR47980 | ||||||||
| NCBI | gene | 171935 | |||||||
| RefSeq | protein | NM_058798.9 | |||||||
| TrEMBL | UniProtAcc | G5EFC1 | |||||||
| UniProt_GCRP | UniProtAcc | G5EFC1 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | rab | ||||||||
| Allele (19) | |||||||||
| Strain | WBStrain00050661 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (30) | |||||||||
| Ortholog (44) | |||||||||
| Paralog (32) | |||||||||
| Structured_description | Concise_description | rab-8 encodes a rab related protein of the Ras GTPase superfamily; RAB-8 functions in sensory neurons in a common ciliary membrane trafficking pathway and in intestinal cells to regulated protein trafficking to the apical plasma membrane; rab-8 also affects ovarian morphology and function, thereby affecting fertility; rab-8 acts downstream of let-60 with respect to vulval development based on genetic analysis; RAB-8 reporter fusion proteins localize to trafficking vesicles in sensory neurons and to the apical membrane and sub-apical structures in the intestine. | Paper_evidence | WBPaper00004697 | |||||
| WBPaper00037733 | |||||||||
| WBPaper00038154 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 02 May 2014 00:00:00 | ||||||||
| Automated_description | Enables GTPase activating protein binding activity and ankyrin repeat binding activity. Involved in several processes, including embryonic genitalia morphogenesis; negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; and protein secretion. Located in apical part of cell and cytoplasmic vesicle. Expressed in body wall musculature. Is an ortholog of human RAB8B (RAB8B, member RAS oncogene family). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | D1037.4 | |||||||
| Corresponding_transcript | D1037.4.1 | ||||||||
| Other_sequence (24) | |||||||||
| Associated_feature | WBsf649039 | ||||||||
| WBsf655264 | |||||||||
| WBsf664054 | |||||||||
| WBsf219164 | |||||||||
| WBsf219165 | |||||||||
| WBsf219166 | |||||||||
| Experimental_info | RNAi_result (19) | ||||||||
| Expr_pattern | Expr9445 | ||||||||
| Expr11047 | |||||||||
| Expr14996 | |||||||||
| Expr14997 | |||||||||
| Expr1025538 | |||||||||
| Expr1032111 | |||||||||
| Expr1147350 | |||||||||
| Expr2015232 | |||||||||
| Expr2033466 | |||||||||
| Drives_construct | WBCnstr00035596 | ||||||||
| WBCnstr00042076 | |||||||||
| Construct_product (11) | |||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (111) | |||||||||
| Interaction (130) | |||||||||
| Map_info | Map | I | Position | -2.90685 | Error | 0.010843 | |||
| Positive | Positive_clone | D1037 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (35) | |||||||||
| Remark | Sequence connection from [Kuwabara PE] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
