rab-8 encodes a rab related protein of the Ras GTPase superfamily; RAB-8 functions in sensory neurons in a common ciliary membrane trafficking pathway and in intestinal cells to regulated protein trafficking to the apical plasma membrane; rab-8 also affects ovarian morphology and function, thereby affecting fertility; rab-8 acts downstream of let-60 with respect to vulval development based on genetic analysis; RAB-8 reporter fusion proteins localize to trafficking vesicles in sensory neurons and to the apical membrane and sub-apical structures in the intestine.
Enables GTPase activating protein binding activity and ankyrin repeat binding activity. Involved in several processes, including embryonic genitalia morphogenesis; negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; and protein secretion. Located in apical part of cell and cytoplasmic vesicle. Expressed in body wall musculature. Is an ortholog of human RAB8B (RAB8B, member RAS oncogene family).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.