WormBase Tree Display for Gene: WBGene00004266
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| WBGene00004266 | SMap | S_parent | Sequence | C39F7 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | rab-1 | Person_evidence | WBPerson451 | |||||
| Sequence_name | C39F7.4 | ||||||||
| Molecular_name | C39F7.4 | ||||||||
| C39F7.4.1 | |||||||||
| CE16905 | |||||||||
| Other_name | Rab protein | Paper_evidence | WBPaper00006512 | ||||||
| CELE_C39F7.4 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | rab-1 | ||||||||
| DB_info | Database | AceView | gene | 5B742 | |||||
| WormQTL | gene | WBGene00004266 | |||||||
| WormFlux | gene | WBGene00004266 | |||||||
| NDB | locus_tag | CELE_C39F7.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004266|UniProtKB=Q9UAQ6 | |||||||
| family | PTHR24073 | ||||||||
| NCBI | gene | 178620 | |||||||
| RefSeq | protein | NM_070996.7 | |||||||
| TrEMBL | UniProtAcc | Q9UAQ6 | |||||||
| UniProt_GCRP | UniProtAcc | Q9UAQ6 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | rab | ||||||||
| Allele (26) | |||||||||
| Strain | WBStrain00002887 | ||||||||
| WBStrain00003426 | |||||||||
| WBStrain00037655 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00100653 | ||||||||
| 00100654 | |||||||||
| 00100655 | |||||||||
| 00100656 | |||||||||
| 00112574 | |||||||||
| 00112575 | |||||||||
| Ortholog (47) | |||||||||
| Paralog (32) | |||||||||
| Structured_description | Concise_description | rab-1 encodes an ortholog of the small Ras-like GTPase Rab1; by homology, RAB-1 is predicted to play a role in intracellular vesicle trafficking, and consistent with this broad role, large-scale RNAi screens indicate that rab-1 activity is required for fertility, movement, and survival; in yeast two-hybrid assays, RAB-1 interacts with TIR-1, a C. elegans SARM ortholog that is required for innate immunity; RNAi studies suggest that RAB-1 and TIR-1 likely function in a pathway that controls expression of antimicrobial peptides such as NLP-29 and NLP-31; rab-1 also appears to play a role in regulating polyglutamine protein aggregation, as rab-1(RNAi) animals show premature accumulation of protein aggregates; in situ hybridization studies indicate that rab-1 is broadly expressed, with elevated levels apparent in the germline. | Paper_evidence | WBPaper00006488 | |||||
| WBPaper00006510 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 24 Jan 2005 00:00:00 | ||||||||
| Automated_description | Predicted to enable GTPase activity. Predicted to be involved in autophagosome assembly and intracellular protein transport. Predicted to be located in endomembrane system. Expressed in tail. Is an ortholog of human RAB1A (RAB1A, member RAS oncogene family); RAB1B (RAB1B, member RAS oncogene family); and RAB1C (RAB1C, member RAS oncogene family (pseudogene)). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C39F7.4 | |||||||
| Corresponding_transcript | C39F7.4.1 | ||||||||
| Other_sequence (105) | |||||||||
| Associated_feature (18) | |||||||||
| Experimental_info | RNAi_result (36) | ||||||||
| Expr_pattern | Chronogram1249 | ||||||||
| Chronogram1839 | |||||||||
| Expr5476 | |||||||||
| Expr5477 | |||||||||
| Expr1019360 | |||||||||
| Expr1032105 | |||||||||
| Expr1146221 | |||||||||
| Expr2015219 | |||||||||
| Expr2033453 | |||||||||
| Drives_construct | WBCnstr00003406 | ||||||||
| WBCnstr00004586 | |||||||||
| WBCnstr00019161 | |||||||||
| WBCnstr00035601 | |||||||||
| Construct_product | WBCnstr00016487 | ||||||||
| WBCnstr00035601 | |||||||||
| Microarray_results (26) | |||||||||
| Expression_cluster (135) | |||||||||
| Interaction (214) | |||||||||
| Map_info | Map | V | Position | -19.8459 | Error | 0.000669 | |||
| Positive | Positive_clone | C39F7 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (27) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
