WormBase Tree Display for Gene: WBGene00004266

WBGene00004266 SMap: S_parent: Sequence: C39F7
  Identity: Version: 1
    Name: CGC_name: rab-1 Person_evidence: WBPerson451
      Sequence_name: C39F7.4
      Molecular_name: C39F7.4
        C39F7.4.1
        CE16905
      Other_name: Rab protein Paper_evidence: WBPaper00006512
        CELE_C39F7.4 Accession_evidence: NDB BX284605
      Public_name: rab-1
    DB_info: Database: AceView gene 5B742
        WormQTL gene WBGene00004266
        WormFlux gene WBGene00004266
        NDB locus_tag CELE_C39F7.4
        Panther gene CAEEL|WormBase=WBGene00004266|UniProtKB=Q9UAQ6
          family PTHR24073
        NCBI gene 178620
        RefSeq protein NM_070996.7
        TrEMBL UniProtAcc Q9UAQ6
        UniProt_GCRP UniProtAcc Q9UAQ6
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:34 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: rab
    Allele (26)
    Strain: WBStrain00002887
      WBStrain00003426
      WBStrain00037655
    RNASeq_FPKM (74)
    GO_annotation: 00100653
      00100654
      00100655
      00100656
      00112574
      00112575
    Ortholog (47)
    Paralog (32)
    Structured_description: Concise_description: rab-1 encodes an ortholog of the small Ras-like GTPase Rab1; by homology, RAB-1 is predicted to play a role in intracellular vesicle trafficking, and consistent with this broad role, large-scale RNAi screens indicate that rab-1 activity is required for fertility, movement, and survival; in yeast two-hybrid assays, RAB-1 interacts with TIR-1, a C. elegans SARM ortholog that is required for innate immunity; RNAi studies suggest that RAB-1 and TIR-1 likely function in a pathway that controls expression of antimicrobial peptides such as NLP-29 and NLP-31; rab-1 also appears to play a role in regulating polyglutamine protein aggregation, as rab-1(RNAi) animals show premature accumulation of protein aggregates; in situ hybridization studies indicate that rab-1 is broadly expressed, with elevated levels apparent in the germline. Paper_evidence: WBPaper00006488
            WBPaper00006510
          Curator_confirmed: WBPerson1843
          Date_last_updated: 24 Jan 2005 00:00:00
      Automated_description: Predicted to enable GTPase activity. Predicted to be involved in autophagosome assembly and intracellular protein transport. Predicted to be located in endomembrane system. Expressed in tail. Is an ortholog of human RAB1A (RAB1A, member RAS oncogene family); RAB1B (RAB1B, member RAS oncogene family); and RAB1C (RAB1C, member RAS oncogene family (pseudogene)). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C39F7.4
    Corresponding_transcript: C39F7.4.1
    Other_sequence (105)
    Associated_feature (18)
  Experimental_info: RNAi_result (36)
    Expr_pattern: Chronogram1249
      Chronogram1839
      Expr5476
      Expr5477
      Expr1019360
      Expr1032105
      Expr1146221
      Expr2015219
      Expr2033453
    Drives_construct: WBCnstr00003406
      WBCnstr00004586
      WBCnstr00019161
      WBCnstr00035601
    Construct_product: WBCnstr00016487
      WBCnstr00035601
    Microarray_results (26)
    Expression_cluster (135)
    Interaction: WBInteraction000009570
      WBInteraction000034256
      WBInteraction000035975
      WBInteraction000036540
      WBInteraction000038401
      WBInteraction000039105
      WBInteraction000039767
      WBInteraction000043883
      WBInteraction000044541
      WBInteraction000045118
      WBInteraction000047178
      WBInteraction000048891
      WBInteraction000049611
      WBInteraction000101850
      WBInteraction000101955
      WBInteraction000102843
      WBInteraction000103974
      WBInteraction000104638
      WBInteraction000104639
      WBInteraction000104764
      WBInteraction000105796
      WBInteraction000105812
      WBInteraction000106181
      WBInteraction000107066
      WBInteraction000107242
      WBInteraction000110160
      WBInteraction000110489
      WBInteraction000110644
      WBInteraction000111105
      WBInteraction000112239
      WBInteraction000112293
      WBInteraction000112794
      WBInteraction000113555
      WBInteraction000120752
      WBInteraction000120777
      WBInteraction000121741
      WBInteraction000122573
      WBInteraction000122825
      WBInteraction000122826
      WBInteraction000126017
      WBInteraction000134090
      WBInteraction000135594
      WBInteraction000136354
      WBInteraction000136434
      WBInteraction000139061
      WBInteraction000139354
      WBInteraction000141629
      WBInteraction000144411
      WBInteraction000146146
      WBInteraction000146671
      WBInteraction000147170
      WBInteraction000148067
      WBInteraction000148772
      WBInteraction000150924
      WBInteraction000151167
      WBInteraction000151275
      WBInteraction000151454
      WBInteraction000156726
      WBInteraction000157664
      WBInteraction000159726
      WBInteraction000163312
      WBInteraction000163941
      WBInteraction000173721
      WBInteraction000175543
      WBInteraction000177406
      WBInteraction000179787
      WBInteraction000181247
      WBInteraction000183259
      WBInteraction000184838
      WBInteraction000185611
      WBInteraction000185612
      WBInteraction000185651
      WBInteraction000185690
      WBInteraction000185732
      WBInteraction000186884
      WBInteraction000189253
      WBInteraction000190697
      WBInteraction000191711
      WBInteraction000197101
      WBInteraction000199167
      WBInteraction000200277
      WBInteraction000200537
      WBInteraction000204183
      WBInteraction000204417
      WBInteraction000206602
      WBInteraction000206817
      WBInteraction000209222
      WBInteraction000213985
      WBInteraction000214269
      WBInteraction000216681
      WBInteraction000228871
      WBInteraction000238544
      WBInteraction000245860
      WBInteraction000246198
      WBInteraction000248057
      WBInteraction000252486
      WBInteraction000261359
      WBInteraction000262876
      WBInteraction000263268
      WBInteraction000264796
      WBInteraction000265976
      WBInteraction000270286
      WBInteraction000272333
      WBInteraction000274342
      WBInteraction000274357
      WBInteraction000274709
      WBInteraction000277689
      WBInteraction000283445
      WBInteraction000285103
      WBInteraction000291269
      WBInteraction000293398
      WBInteraction000298658
      WBInteraction000303027
      WBInteraction000309882
      WBInteraction000316134
      WBInteraction000320536
      WBInteraction000326135
      WBInteraction000326488
      WBInteraction000329570
      WBInteraction000332587
      WBInteraction000333318
      WBInteraction000334227
      WBInteraction000338709
      WBInteraction000342139
      WBInteraction000342503
      WBInteraction000355073
      WBInteraction000355074
      WBInteraction000356241
      WBInteraction000358330
      WBInteraction000364607
      WBInteraction000366690
      WBInteraction000366885
      WBInteraction000367886
      WBInteraction000375880
      WBInteraction000376768
      WBInteraction000379197
      WBInteraction000383672
      WBInteraction000386965
      WBInteraction000387088
      WBInteraction000388681
      WBInteraction000398265
      WBInteraction000401470
      WBInteraction000401471
      WBInteraction000404810
      WBInteraction000407777
      WBInteraction000407929
      WBInteraction000410672
      WBInteraction000417502
      WBInteraction000417553
      WBInteraction000421841
      WBInteraction000424509
      WBInteraction000424933
      WBInteraction000429167
      WBInteraction000435401
      WBInteraction000438128
      WBInteraction000440838
      WBInteraction000440852
      WBInteraction000442057
      WBInteraction000447770
      WBInteraction000448851
      WBInteraction000449618
      WBInteraction000450657
      WBInteraction000454425
      WBInteraction000455278
      WBInteraction000455999
      WBInteraction000458401
      WBInteraction000459219
      WBInteraction000461763
      WBInteraction000462004
      WBInteraction000462578
      WBInteraction000462752
      WBInteraction000462997
      WBInteraction000463743
      WBInteraction000464224
      WBInteraction000464390
      WBInteraction000465434
      WBInteraction000466253
      WBInteraction000467139
      WBInteraction000468650
      WBInteraction000469109
      WBInteraction000470571
      WBInteraction000470890
      WBInteraction000470901
      WBInteraction000471122
      WBInteraction000471123
      WBInteraction000471124
      WBInteraction000471743
      WBInteraction000472434
      WBInteraction000472435
      WBInteraction000472436
      WBInteraction000472437
      WBInteraction000473029
      WBInteraction000473168
      WBInteraction000473344
      WBInteraction000475468
      WBInteraction000502377
      WBInteraction000504058
      WBInteraction000505083
      WBInteraction000505142
      WBInteraction000542836
      WBInteraction000550153
      WBInteraction000554115
      WBInteraction000559123
      WBInteraction000564184
      WBInteraction000572403
      WBInteraction000572825
      WBInteraction000573518
      WBInteraction000574478
      WBInteraction000577690
      WBInteraction000578652
      WBInteraction000579162
      WBInteraction000579187
      WBInteraction000580281
      WBInteraction000583097
  Map_info: Map: V Position: -19.8459 Error: 0.000669
    Positive: Positive_clone: C39F7 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (27)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene