WormBase Tree Display for Gene: WBGene00004267
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| WBGene00004267 | SMap | S_parent | Sequence | C18A3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | rab-3 | Person_evidence | WBPerson451 | |||||
| Sequence_name | C18A3.6 | ||||||||
| Molecular_name | C18A3.6a | ||||||||
| C18A3.6a.1 | |||||||||
| CE23555 | |||||||||
| C18A3.6b | |||||||||
| CE20518 | |||||||||
| C18A3.6b.1 | |||||||||
| Other_name | RAB3/A | ||||||||
| rbl-3 | |||||||||
| rab3 | Accession_evidence | EMBL | AB112928 | ||||||
| CELE_C18A3.6 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | rab-3 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | rab | ||||||||
| Allele (101) | |||||||||
| Legacy_information | [C.elegansII] y250 : mild Unc, Che, Egl defects; Ric.OA1: y251 (similar; both y250 and y251 are missense alleles). Encodes homolog of mammalian rab3 (73% identity to human Rab3a). Dominant negative transgene leads to Ric, some Unc, or L1 lethality like cha-1(0). [NM] | ||||||||
| Strain (11) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (37) | |||||||||
| Ortholog (50) | |||||||||
| Paralog (32) | |||||||||
| Structured_description | Concise_description | rab-3 encodes a rab3 homolog, a member of the Ras GTPase superfamily, and affects sensitivity to aldicarb and the distribution of synaptic vesicle populations and thereby affects synaptic transmission, track amplitude and speed of movement, chemotaxis to isoamyl alcohol, affects pharyngeal pump durations, and may only slightly affect male mating behavior; requires aex-3 for localization to synapse-rich regions in axons and it is expressed in most or all neurons. | Paper_evidence | WBPaper00002776 | |||||
| WBPaper00002918 | |||||||||
| WBPaper00004331 | |||||||||
| WBPaper00005654 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable GTPase activity and myosin V binding activity. Involved in several processes, including positive regulation of anterior/posterior axon guidance; regulation of GABAergic synaptic transmission; and ventral cord development. Located in neuron projection and synaptic vesicle. Expressed in nervous system; neurons; and uv1. Used to study alcohol use disorder and epilepsy. Is an ortholog of human RAB3A (RAB3A, member RAS oncogene family). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1574 | Homo sapiens | Paper_evidence | WBPaper00031669 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 13 Jun 2019 00:00:00 | ||||||||
| DOID:1826 | Homo sapiens | Paper_evidence | WBPaper00035198 | ||||||
| Curator_confirmed | WBPerson38202 | ||||||||
| Date_last_updated | 04 Jun 2018 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000559 | ||||||||
| WBDOannot00000713 | |||||||||
| Molecular_info | Corresponding_CDS | C18A3.6a | |||||||
| C18A3.6b | |||||||||
| Corresponding_transcript | C18A3.6a.1 | ||||||||
| C18A3.6b.1 | |||||||||
| Other_sequence (26) | |||||||||
| Associated_feature (13) | |||||||||
| Experimental_info | RNAi_result (17) | ||||||||
| Expr_pattern (15) | |||||||||
| Drives_construct (108) | |||||||||
| Construct_product (92) | |||||||||
| Antibody | WBAntibody00000151 | ||||||||
| WBAntibody00000729 | |||||||||
| WBAntibody00001350 | |||||||||
| WBAntibody00001587 | |||||||||
| Microarray_results (28) | |||||||||
| Expression_cluster (233) | |||||||||
| Interaction (66) | |||||||||
| Map_info | Map | II | Position | -0.958332 | Error | 0.001327 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C02C12 | Author_evidence | Nonet MI | |||||
| C18A3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| F11G1 | Author_evidence | Nonet MI | |||||||
| Mapping_data | Multi_point | 3342 | |||||||
| 3346 | |||||||||
| Reference (180) | |||||||||
| Method | Gene |
