WormBase Tree Display for Gene: WBGene00016440
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| WBGene00016440 | SMap | S_parent | Sequence | C35D10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | gipc-1 | Person_evidence | WBPerson260 | |||||
| Sequence_name | C35D10.2 | ||||||||
| Molecular_name | C35D10.2 | ||||||||
| C35D10.2.1 | |||||||||
| CE01196 | |||||||||
| Other_name | CELE_C35D10.2 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | gipc-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:57 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 07 Feb 2012 16:30:56 | WBPerson2970 | Name_change | CGC_name | gipc-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gipc | ||||||||
| Allele (21) | |||||||||
| Strain | WBStrain00000431 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| Ortholog (49) | |||||||||
| Paralog | WBGene00009681 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Automated_description | Expressed in spermatid. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 15 and oculopharyngodistal myopathy 2. Human GIPC1 enables signaling receptor binding activity. Is predicted to encode a protein with the following domains: PDZ domain-containing protein GIPC1/2/3; PDZ superfamily; and PDZ domain. Is an ortholog of human GIPC1 (GIPC PDZ domain containing family member 1) and GIPC3 (GIPC PDZ domain containing family member 3). | Paper_evidence | WBPaper00065943 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00031384 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 24 Jul 2013 00:00:00 | ||||||||
| Potential_model | DOID:0110470 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18183) | |||||
| DOID:0081298 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1226) | ||||||
| Disease_relevance | In an elegans model of Parkinson''s disease, where human alpha-synuclein was overexpressed, RNA interference studies showed that the elegans gipc-1/GIPC (GAIP-interacting protein, a conserved cellular scaffold-type protein), significantly protected against age- and dose-dependent degeneration in the dopamine neurons of transgenic worms; such models allow the identification of human modifier proteins of alpha-synuclein dependent misfolding and neurodegeneration, these proteins may also be new potential targets for therapeutic intervention. | Homo sapiens | Paper_evidence | WBPaper00031384 | |||||
| Accession_evidence | OMIM | 605072 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 24 Jul 2013 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000214 | ||||||||
| Molecular_info | Corresponding_CDS | C35D10.2 | |||||||
| Corresponding_transcript | C35D10.2.1 | ||||||||
| Other_sequence (16) | |||||||||
| Associated_feature | WBsf976120 | ||||||||
| WBsf224818 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00011661 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00022568 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00005097 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090599 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076199 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00041983 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00029578 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001337 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram924 | ||||||||
| Expr5437 | |||||||||
| Expr15153 | |||||||||
| Expr1022698 | |||||||||
| Expr1145994 | |||||||||
| Expr2012040 | |||||||||
| Expr2030276 | |||||||||
| Drives_construct | WBCnstr00002891 | ||||||||
| WBCnstr00028069 | |||||||||
| Construct_product | WBCnstr00006223 | ||||||||
| WBCnstr00007333 | |||||||||
| WBCnstr00028069 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (288) | |||||||||
| Interaction (224) | |||||||||
| Map_info | Map | III | Position | -2.41286 | |||||
| Positive | Positive_clone | C35D10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00027342 | ||||||||
| WBPaper00031384 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00039525 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00056589 | |||||||||
| WBPaper00060732 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
