WormBase Tree Display for Gene: WBGene00015146
expand all nodes | collapse all nodes | view schema
| WBGene00015146 | SMap | S_parent | Sequence | B0336 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | abi-1 | Person_evidence | WBPerson608 | |||||
| WBPerson1490 | |||||||||
| Sequence_name | B0336.6 | ||||||||
| Molecular_name | B0336.6 | ||||||||
| B0336.6.1 | |||||||||
| CE29545 | |||||||||
| B0336.6.2 | |||||||||
| Other_name | CELE_B0336.6 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | abi-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:55 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 09 Oct 2007 15:40:26 | WBPerson2970 | Name_change | CGC_name | abi-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | abi | ||||||||
| Allele (49) | |||||||||
| Strain | WBStrain00031542 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (33) | |||||||||
| Ortholog (49) | |||||||||
| Structured_description | Concise_description | abi-1 encodes an Abl interactor orthologous to human SSH3BP1 (ABI1; OMIM:603050, mutated in acute myeloid leukemia), ABI-2 (OMIM:606442), and NESH (OMIM:606363); abi-1 is required for epidermal cell migrations during embryonic enclosure, proper migration of the excretory cell, distal tip cell, and mechanosensory and motoneurons, and apoptotic cell engulfment; ABI-1 physically interacts with the MIG-10 and the N-terminus of UNC-53/NAV2, which may provide a link between ABI-1, MIG-10 and the ARP2/3 complex; ABI-1 also physically interacts with the ABL-1 tyrosine kinase; ABI-1 is expressed in a number of head and nerve ring neurons including the amphid interneurons AIYL/R and the RMEL/R motoneurons, several types of ventral cord motoneurons and the coelomocytes; in neurons, ABI-1 localizes to the cell bodies, dendrites and commissural axons. | Paper_evidence (14) | ||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 13 Nov 2012 00:00:00 | ||||||||
| Automated_description | Enables SH3 domain binding activity and protein kinase binding activity. Involved in several processes, including positive regulation of endocytosis; presynaptic actin cytoskeleton organization; and synaptic vesicle clustering. Located in axon; cytoplasm; and somatodendritic compartment. Expressed in coelomocyte; head neurons; and ventral cord neurons. Is an ortholog of human ABI1 (abl interactor 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | B0336.6 | |||||||
| Corresponding_transcript | B0336.6.1 | ||||||||
| B0336.6.2 | |||||||||
| Other_sequence (99) | |||||||||
| Associated_feature | WBsf651069 | ||||||||
| WBsf992492 | |||||||||
| WBsf1014936 | |||||||||
| WBsf226717 | |||||||||
| Experimental_info | RNAi_result (58) | ||||||||
| Expr_pattern | Expr8549 | ||||||||
| Expr1011958 | |||||||||
| Expr1036479 | |||||||||
| Expr1143128 | |||||||||
| Expr2009092 | |||||||||
| Expr2027328 | |||||||||
| Drives_construct | WBCnstr00013361 | ||||||||
| WBCnstr00029052 | |||||||||
| Construct_product | WBCnstr00013361 | ||||||||
| WBCnstr00018373 | |||||||||
| WBCnstr00018374 | |||||||||
| WBCnstr00018375 | |||||||||
| WBCnstr00018376 | |||||||||
| WBCnstr00029052 | |||||||||
| Antibody | WBAntibody00001616 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (132) | |||||||||
| Interaction (149) | |||||||||
| Map_info | Map | III | Position | -1.45421 | Error | 0.000689 | |||
| Positive | Positive_clone | B0336 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (26) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
