WormBase Tree Display for Gene: WBGene00018635
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| WBGene00018635 | SMap | S_parent | Sequence | CHROMOSOME_IV | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | nprl-2 | Person_evidence | WBPerson237 | |||||
| Sequence_name | F49E8.1 | ||||||||
| Molecular_name | F49E8.1a | ||||||||
| F49E8.1a.1 | |||||||||
| CE33650 | |||||||||
| F49E8.1b | |||||||||
| CE51825 | |||||||||
| F49E8.1b.1 | |||||||||
| Other_name | CELE_F49E8.1 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | nprl-2 | ||||||||
| DB_info | Database | AceView | gene | 4I323 | |||||
| WormQTL | gene | WBGene00018635 | |||||||
| WormFlux | gene | WBGene00018635 | |||||||
| NDB | locus_tag | CELE_F49E8.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00018635|UniProtKB=W6RQZ3 | |||||||
| family | PTHR12991 | ||||||||
| NCBI | gene | 177532 | |||||||
| RefSeq | protein | NM_001392334.1 | |||||||
| NM_001392333.1 | |||||||||
| TrEMBL | UniProtAcc | W6SBD7 | |||||||
| W6RQZ3 | |||||||||
| UniProt_GCRP | UniProtAcc | W6RQZ3 | |||||||
| OMIM | gene | 607072 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:00 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 11 Apr 2012 13:49:30 | WBPerson2970 | Name_change | CGC_name | nprl-2 | ||||
| 3 | 06 Mar 2018 14:46:01 | WBPerson4025 | Event | Split_into | WBGene00302976 | ||||
| Split_into | WBGene00302976 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nprl | ||||||||
| Allele (33) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00105446 | ||||||||
| 00105447 | |||||||||
| 00105448 | |||||||||
| 00105449 | |||||||||
| 00105450 | |||||||||
| 00105451 | |||||||||
| 00105452 | |||||||||
| Contained_in_operon | CEOP5598 | ||||||||
| Ortholog (40) | |||||||||
| Structured_description | Automated_description | Predicted to contribute to GTPase activator activity. Predicted to be involved in cellular response to amino acid starvation; negative regulation of TORC1 signaling; and positive regulation of autophagy. Predicted to be located in vacuolar membrane. Predicted to be part of GATOR1 complex. Human ortholog(s) of this gene implicated in focal epilepsy. Is an ortholog of human NPRL2 (NPR2 like, GATOR1 complex subunit). | Paper_evidence | WBPaper00065943 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:2234 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:24969) | ||||
| Molecular_info | Corresponding_CDS | F49E8.1a | |||||||
| F49E8.1b | |||||||||
| Corresponding_CDS_history | F49E8.1:wp97 | ||||||||
| F49E8.1:wp241 | |||||||||
| F49E8.1a:wp256 | |||||||||
| F49E8.1b:wp256 | |||||||||
| F49E8.1c:wp264 | |||||||||
| Corresponding_transcript | F49E8.1a.1 | ||||||||
| F49E8.1b.1 | |||||||||
| Other_sequence (24) | |||||||||
| Associated_feature | WBsf646091 | ||||||||
| WBsf646092 | |||||||||
| WBsf660306 | |||||||||
| WBsf997010 | |||||||||
| WBsf1017733 | |||||||||
| WBsf228548 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00061819 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00032550 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00015331 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00047868 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1019604 | ||||||||
| Expr1038019 | |||||||||
| Expr1151698 | |||||||||
| Expr2014430 | |||||||||
| Expr2032671 | |||||||||
| Drives_construct | WBCnstr00026371 | ||||||||
| Construct_product | WBCnstr00026371 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (82) | |||||||||
| Interaction (35) | |||||||||
| Map_info | Map | IV | Position | 3.35571 | |||||
| Positive | Positive_clone | F49E8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00038491 | ||||||||
| WBPaper00042436 | |||||||||
| WBPaper00052740 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00055173 | |||||||||
| WBPaper00061251 | |||||||||
| WBPaper00064505 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
