WormBase Tree Display for Gene: WBGene00005023
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| WBGene00005023 | Evidence | Paper_evidence | WBPaper00005867 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | T24D1 | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | sqv-5 | Person_evidence | WBPerson268 | |||||
| Sequence_name | T24D1.1 | ||||||||
| Molecular_name | T24D1.1a | ||||||||
| T24D1.1a.1 | |||||||||
| CE50401 | |||||||||
| T24D1.1b | |||||||||
| CE39182 | |||||||||
| T24D1.1c | |||||||||
| CE50402 | |||||||||
| T24D1.1b.1 | |||||||||
| T24D1.1c.1 | |||||||||
| Other_name | ChSy-S | Accession_evidence | EMBL | AB088398 | |||||
| CELE_T24D1.1 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | sqv-5 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 02 Mar 2018 11:09:16 | WBPerson4025 | Event | Split_into | WBGene00303082 | ||||
| Split_into | WBGene00303082 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sqv | ||||||||
| Allele (53) | |||||||||
| Legacy_information | [Herman T] sqv for squashed vulva. morphology of L4 vulva abnormal (invagination considerably reduced). hermaphrodites self-sterile. | ||||||||
| [C.elegansII] n3039 : morphology of L4 vulva abnormal (invagination considerably reduced); hermaphrodites self-sterile. [MT] | |||||||||
| Strain | WBStrain00027364 | ||||||||
| WBStrain00027385 | |||||||||
| WBStrain00028700 | |||||||||
| WBStrain00028702 | |||||||||
| WBStrain00007564 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog (44) | |||||||||
| Paralog | WBGene00003253 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | sqv-5 encodes a chondroitin synthase that both initiates and elongates chondroitin chains (unlike human chondroitin synthase, which only elongates them); SQV-5 is required for cytokinesis (e.g., at the one-cell embryo stage), gonad migration, and vulval morphogenesis (by expanding the extracellular space of the vulva in L4 larvae); the common requirement for SQV-5 in both processes may be to promote filling an extracellular space with fluid (either in the eggshell, or underneath the L4 cuticle); SQV-5 colocalizes with SQV-1 at punctate foci (probably the Golgi apparatus) in the cytoplasm of the vulva, the uterus and oocytes; SQV-5 is most similar to human chondroitin synthase (KIAA0990) and Drosophila CG9220. | Paper_evidence | WBPaper00003405 | |||||
| WBPaper00003736 | |||||||||
| WBPaper00003906 | |||||||||
| WBPaper00005540 | |||||||||
| WBPaper00005867 | |||||||||
| WBPaper00005868 | |||||||||
| WBPaper00012887 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables enzyme binding activity. Involved in several processes, including egg-laying behavior; positive regulation of vulval development; and vulval development. Located in cytoplasm. Expressed in oocyte; uterus; and vulva. Human ortholog(s) of this gene implicated in temtamy preaxial brachydactyly syndrome. Is an ortholog of human CHSY1 (chondroitin sulfate synthase 1) and CHSY3 (chondroitin sulfate synthase 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050814 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17198) | ||||
| Molecular_info | Corresponding_CDS | T24D1.1a | |||||||
| T24D1.1b | |||||||||
| T24D1.1c | |||||||||
| Corresponding_CDS_history | T24D1.1a:wp149 | ||||||||
| T24D1.1a:wp246 | |||||||||
| T24D1.1b:wp149 | |||||||||
| T24D1.1d:wp264 | |||||||||
| Corresponding_transcript | T24D1.1a.1 | ||||||||
| T24D1.1b.1 | |||||||||
| T24D1.1c.1 | |||||||||
| Other_sequence (32) | |||||||||
| Associated_feature (14) | |||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern | Expr2566 | ||||||||
| Expr3104 | |||||||||
| Expr1023591 | |||||||||
| Expr1032506 | |||||||||
| Expr1157585 | |||||||||
| Expr2016123 | |||||||||
| Expr2034358 | |||||||||
| Drives_construct | WBCnstr00018534 | ||||||||
| WBCnstr00035261 | |||||||||
| Construct_product | WBCnstr00018534 | ||||||||
| WBCnstr00035261 | |||||||||
| Antibody | WBAntibody00000621 | ||||||||
| WBAntibody00001858 | |||||||||
| Microarray_results (29) | |||||||||
| Expression_cluster (160) | |||||||||
| Interaction (66) | |||||||||
| Map_info | Map | I | Position | 4.09354 | Error | 0.007416 | |||
| Positive | Positive_clone | T24D1 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 3143 | |||||||
| 3144 | |||||||||
| 5407 | |||||||||
| 5544 | |||||||||
| Reference (32) | |||||||||
| Method | Gene |
