WormBase Tree Display for Gene: WBGene00002297
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| WBGene00002297 | SMap | S_parent | Sequence | T19E10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | ect-2 | Paper_evidence | WBPaper00026774 | |||||
| Person_evidence | WBPerson237 | ||||||||
| Sequence_name | T19E10.1 | ||||||||
| Molecular_name | T19E10.1a | ||||||||
| T19E10.1a.1 | |||||||||
| CE18264 | |||||||||
| T19E10.1b | |||||||||
| CE01671 | |||||||||
| T19E10.1a.2 | |||||||||
| T19E10.1b.1 | |||||||||
| Other_name | let-21 | Person_evidence | WBPerson533 | ||||||
| CELE_T19E10.1 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | ect-2 | ||||||||
| DB_info | Database | AceView | gene | 2L70 | |||||
| WormQTL | gene | WBGene00002297 | |||||||
| WormFlux | gene | WBGene00002297 | |||||||
| NDB | locus_tag | CELE_T19E10.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00002297|UniProtKB=Q9U364 | |||||||
| family | PTHR16777 | ||||||||
| NCBI | gene | 174658 | |||||||
| RefSeq | protein | NM_063918.4 | |||||||
| NM_063917.6 | |||||||||
| TREEFAM | TREEFAM_ID | TF101161 | |||||||
| TrEMBL | UniProtAcc | Q9U364 | |||||||
| Q22590 | |||||||||
| UniProt_GCRP | UniProtAcc | Q9U364 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 28 Sep 2005 14:32:53 | WBPerson2970 | Event | Acquires_merge | WBGene00011845 | ||||
| Name_change | CGC_name | ect-2 | |||||||
| Other_name | let-21 | ||||||||
| Acquires_merge | WBGene00011845 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ect | ||||||||
| Allele (104) | |||||||||
| Legacy_information | e1778 : sterile uncoordinated polynucleate oocytes. NA1. | ||||||||
| [C.elegansII] e1778 : sterile uncoordinated polynucleate oocytes, abnormal positioning of germ linenuclei. NA1. [NJ] | |||||||||
| Strain | WBStrain00026531 | ||||||||
| WBStrain00000145 | |||||||||
| WBStrain00004473 | |||||||||
| WBStrain00004792 | |||||||||
| WBStrain00007536 | |||||||||
| WBStrain00022358 | |||||||||
| WBStrain00022359 | |||||||||
| WBStrain00022369 | |||||||||
| WBStrain00022370 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (43) | |||||||||
| Structured_description | Concise_description | ect-2 encodes, by alternative splicing, two isoforms of a putative RHO guanine nucleotide exchange factor (RhoGEF) required for cytokinesis of early embryos and epidermal P cells, as well as cell polarity of early embryos and migration of epidermal P cells; ECT-2 is thus required for normal vulval differentiation and locomotion, along with fertility and embryonic viability; ECT-2 also activates LET-60/RAS signalling during vulval development, requiring RHO-1 to do so; ECT-2 is orthologous to the proto-oncogene ECT2 (OMIM:600586) and Drosophila PEBBLE; ECT-2 has two BRCT domains and a RhoGEF domain; ect-2 is expressed ubiquitously during embryogenesis, but restricted to Q cells in early L1 larvae; ect-2's expression then broadens to P-cell derivatives and distal tip cells, vulval precursor cells and their derivatives, and some adult neurons; ECT-2 is symmetrically distributed in unfertilized oocytes, but then temporarily becomes asymmetrically depleted around the centrosomal protein SPD-5, and is required for initial anteroposterior polarization of the newly fertilized embryo; anterior localization of PAR-6 in newly fertilized embryos requires ECT-2, which colocalizes with the nonmuscle myosin NMY-2 in the early embryonic cell cortex; the boundary of anterior versus posterior domains in the early embryo depends on the antagonistic activities of ECT-2 versus RGA-3/4; a hypomorphic ect-2 mutation suppresses the multivulva phenotype of lin-32, whereas a gain-of-function ect-2 mutation hyperinduces vulval development; ECT-2 is expressed in embryonic and P cells. | Paper_evidence | WBPaper00005764 | |||||
| WBPaper00026774 | |||||||||
| WBPaper00026937 | |||||||||
| WBPaper00028358 | |||||||||
| WBPaper00028395 | |||||||||
| WBPaper00028408 | |||||||||
| WBPaper00031005 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 29 Dec 2007 00:00:00 | ||||||||
| Automated_description | Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; mitotic cytokinesis; and regulation of actin filament-based process. Located in cell cortex. Expressed in several structures, including P1.p; germ line; hermaphrodite gonad; neuroblasts; and somatic gonad precursor. Is an ortholog of human ECT2 (epithelial cell transforming 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T19E10.1a | |||||||
| T19E10.1b | |||||||||
| Corresponding_transcript | T19E10.1a.1 | ||||||||
| T19E10.1a.2 | |||||||||
| T19E10.1b.1 | |||||||||
| Other_sequence | JI166080.1 | ||||||||
| JI165204.1 | |||||||||
| CBC02373_1 | |||||||||
| CR09386 | |||||||||
| CRC10546_1 | |||||||||
| JO469734.1 | |||||||||
| Associated_feature | WBsf650517 | ||||||||
| WBsf666061 | |||||||||
| WBsf666062 | |||||||||
| WBsf989481 | |||||||||
| WBsf1013093 | |||||||||
| WBsf223831 | |||||||||
| WBsf223832 | |||||||||
| WBsf223833 | |||||||||
| Experimental_info | RNAi_result (27) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00005769 | ||||||||
| WBCnstr00012959 | |||||||||
| WBCnstr00017410 | |||||||||
| WBCnstr00018634 | |||||||||
| WBCnstr00036335 | |||||||||
| Construct_product | WBCnstr00004729 | ||||||||
| WBCnstr00009313 | |||||||||
| WBCnstr00012397 | |||||||||
| WBCnstr00017410 | |||||||||
| WBCnstr00018634 | |||||||||
| WBCnstr00036335 | |||||||||
| Microarray_results (32) | |||||||||
| Expression_cluster (154) | |||||||||
| Interaction (54) | |||||||||
| Map_info | Map | II | Position | 3.12567 | Error | 0.000108 | |||
| Positive | Positive_clone | T19E10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 706 | |||||||
| Multi_point | 591 | ||||||||
| Pos_neg_data | 7149 | ||||||||
| Reference (64) | |||||||||
| Method | Gene |
