WormBase Tree Display for Gene: WBGene00002297
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WBGene00002297 | SMap | S_parent | Sequence | T19E10 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | ect-2 | Paper_evidence | WBPaper00026774 | |||
Person_evidence | WBPerson237 | ||||||
Sequence_name | T19E10.1 | ||||||
Molecular_name | T19E10.1a | ||||||
T19E10.1a.1 | |||||||
CE18264 | |||||||
T19E10.1b | |||||||
CE01671 | |||||||
T19E10.1a.2 | |||||||
T19E10.1b.1 | |||||||
Other_name | let-21 | Person_evidence | WBPerson533 | ||||
CELE_T19E10.1 | Accession_evidence | NDB | BX284602 | ||||
Public_name | ect-2 | ||||||
DB_info | Database | AceView | gene | 2L70 | |||
WormQTL | gene | WBGene00002297 | |||||
WormFlux | gene | WBGene00002297 | |||||
NDB | locus_tag | CELE_T19E10.1 | |||||
Panther | gene | CAEEL|WormBase=WBGene00002297|UniProtKB=Q9U364 | |||||
family | PTHR16777 | ||||||
NCBI | gene | 174658 | |||||
RefSeq | protein | NM_063918.4 | |||||
NM_063917.6 | |||||||
TREEFAM | TREEFAM_ID | TF101161 | |||||
TrEMBL | UniProtAcc | Q9U364 | |||||
Q22590 | |||||||
UniProt_GCRP | UniProtAcc | Q9U364 | |||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Acquires_merge | WBGene00011845 | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | ect | ||||||
Allele (104) | |||||||
Legacy_information | e1778 : sterile uncoordinated polynucleate oocytes. NA1. | ||||||
[C.elegansII] e1778 : sterile uncoordinated polynucleate oocytes, abnormal positioning of germ linenuclei. NA1. [NJ] | |||||||
Strain | WBStrain00026531 | ||||||
WBStrain00000145 | |||||||
WBStrain00004473 | |||||||
WBStrain00004792 | |||||||
WBStrain00007536 | |||||||
WBStrain00022358 | |||||||
WBStrain00022359 | |||||||
WBStrain00022369 | |||||||
WBStrain00022370 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (20) | |||||||
Ortholog (43) | |||||||
Structured_description | Concise_description | ect-2 encodes, by alternative splicing, two isoforms of a putative RHO guanine nucleotide exchange factor (RhoGEF) required for cytokinesis of early embryos and epidermal P cells, as well as cell polarity of early embryos and migration of epidermal P cells; ECT-2 is thus required for normal vulval differentiation and locomotion, along with fertility and embryonic viability; ECT-2 also activates LET-60/RAS signalling during vulval development, requiring RHO-1 to do so; ECT-2 is orthologous to the proto-oncogene ECT2 (OMIM:600586) and Drosophila PEBBLE; ECT-2 has two BRCT domains and a RhoGEF domain; ect-2 is expressed ubiquitously during embryogenesis, but restricted to Q cells in early L1 larvae; ect-2's expression then broadens to P-cell derivatives and distal tip cells, vulval precursor cells and their derivatives, and some adult neurons; ECT-2 is symmetrically distributed in unfertilized oocytes, but then temporarily becomes asymmetrically depleted around the centrosomal protein SPD-5, and is required for initial anteroposterior polarization of the newly fertilized embryo; anterior localization of PAR-6 in newly fertilized embryos requires ECT-2, which colocalizes with the nonmuscle myosin NMY-2 in the early embryonic cell cortex; the boundary of anterior versus posterior domains in the early embryo depends on the antagonistic activities of ECT-2 versus RGA-3/4; a hypomorphic ect-2 mutation suppresses the multivulva phenotype of lin-32, whereas a gain-of-function ect-2 mutation hyperinduces vulval development; ECT-2 is expressed in embryonic and P cells. | Paper_evidence | WBPaper00005764 | |||
WBPaper00026774 | |||||||
WBPaper00026937 | |||||||
WBPaper00028358 | |||||||
WBPaper00028395 | |||||||
WBPaper00028408 | |||||||
WBPaper00031005 | |||||||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 29 Dec 2007 00:00:00 | ||||||
Automated_description | Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; mitotic cytokinesis; and regulation of actin filament-based process. Located in cell cortex. Expressed in several structures, including P1.p; germ line; hermaphrodite gonad; neuroblasts; and somatic gonad precursor. Is an ortholog of human ECT2 (epithelial cell transforming 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | T19E10.1a | |||||
T19E10.1b | |||||||
Corresponding_transcript | T19E10.1a.1 | ||||||
T19E10.1a.2 | |||||||
T19E10.1b.1 | |||||||
Other_sequence | JI166080.1 | ||||||
JI165204.1 | |||||||
CBC02373_1 | |||||||
CR09386 | |||||||
CRC10546_1 | |||||||
JO469734.1 | |||||||
Associated_feature | WBsf650517 | ||||||
WBsf666061 | |||||||
WBsf666062 | |||||||
WBsf989481 | |||||||
WBsf1013093 | |||||||
WBsf223831 | |||||||
WBsf223832 | |||||||
WBsf223833 | |||||||
Experimental_info | RNAi_result (27) | ||||||
Expr_pattern (12) | |||||||
Drives_construct | WBCnstr00005769 | ||||||
WBCnstr00012959 | |||||||
WBCnstr00017410 | |||||||
WBCnstr00018634 | |||||||
WBCnstr00036335 | |||||||
Construct_product | WBCnstr00004729 | ||||||
WBCnstr00009313 | |||||||
WBCnstr00012397 | |||||||
WBCnstr00017410 | |||||||
WBCnstr00018634 | |||||||
WBCnstr00036335 | |||||||
Microarray_results (32) | |||||||
Expression_cluster (154) | |||||||
Interaction (54) | |||||||
Map_info | Map | II | Position | 3.12567 | Error | 0.000108 | |
Positive | Positive_clone | T19E10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | 2_point | 706 | |||||
Multi_point | 591 | ||||||
Pos_neg_data | 7149 | ||||||
Reference (64) | |||||||
Method | Gene |