WormBase Tree Display for Gene: WBGene00022121
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| WBGene00022121 | SMap | S_parent | Sequence | Y71F9AM | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | cogc-3 | Paper_evidence | WBPaper00026979 | |||||
| Person_evidence | WBPerson449 | ||||||||
| Sequence_name | Y71F9AM.4 | ||||||||
| Molecular_name | Y71F9AM.4a | ||||||||
| Y71F9AM.4a.1 | |||||||||
| CE37070 | |||||||||
| Y71F9AM.4b | |||||||||
| CE33242 | |||||||||
| Y71F9AM.4b.1 | |||||||||
| Other_name | mig-29 | Person_evidence | WBPerson261 | ||||||
| Y71F9AM.b | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| Y71F9AM.c | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| Y71F9AM.d | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_Y71F9AM.4 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | cogc-3 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:05 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 19 Jul 2004 09:41:43 | WBPerson1849 | Event | Acquires_merge | WBGene00022120 | ||||
| 3 | 16 Jan 2006 17:03:07 | WBPerson2970 | Name_change | CGC_name | cogc-3 | ||||
| Other_name | mig-29 | ||||||||
| Acquires_merge | WBGene00022120 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cogc | ||||||||
| Allele (363) | |||||||||
| Strain | WBStrain00028710 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Contained_in_operon | CEOP1076 | ||||||||
| Ortholog (42) | |||||||||
| Structured_description | Concise_description | cogc-3 encodes an ortholog of mammalian COG-3/Sec34, a subunit of lobe Aof the conserved oligomeric Golgi complex (COGC); COGC-3 is required fornormal gonadal distal tip cell migration, a process that also requiresCOGC-1 and six other orthologs of COGC subunits; COGC-3 is also requiredfor normal vulval morphology, growth rate, ventral nerve cordfasciculation, and adult locomotion; COGC-3 has a predicted coiled-coilN-terminal domain, and a C-terminal EEA1-like domain that might linkvesicles to endosomes; COGC-3 protein is found in most somatic cells butabsent from germline; COGC-1 co-precipitates with COGC-3, and the amountof COGC-3 is lowered in a cogc-1 mutant, implying that these proteinsnot only bind one another but stabilize one another in vivo; in cogc-3mutants, MIG-23 is abnormally localized and expressed within cells; incogc-3 mutants, MIG-23's substrate MIG-17 is underglycosylated and failsto bind to the gonadal basement membrane, but is still secreted normallyfrom muscle cells; transgenic expression of cogc-3 in muscle cells, butnot in touch neurons, partially rescues cogc-3's migration phenotype;however, coexpression of cogc-3 with mig-17 in touch neurons doespartially rescue migration; cogc-1, cogc-3, and mig-17 null mutants donot enhance one another, indicating a shared genetic pathway; like otherlobe A subunits in both C. elegans and S. cerevisiae, COGC-3 is stronglyrequired for normal function, while lobe B subunits are only partiallyrequired in either worms or yeast. | Paper_evidence | WBPaper00026979 | |||||
| WBPaper00028363 | |||||||||
| WBPaper00028598 | |||||||||
| WBPaper00028599 | |||||||||
| WBPaper00028600 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 25 Oct 2006 00:00:00 | ||||||||
| Automated_description | Involved in gonad morphogenesis and regulation of cell migration. Located in Golgi apparatus and endoplasmic reticulum. Expressed in intestine; pharynx; seam cell; and vulva. Is an ortholog of human COG3 (component of oligomeric golgi complex 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050571 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18619) | ||||
| Molecular_info | Corresponding_CDS | Y71F9AM.4a | |||||||
| Y71F9AM.4b | |||||||||
| Corresponding_CDS_history | Y71F9AM.4:wp127 | ||||||||
| Corresponding_transcript | Y71F9AM.4a.1 | ||||||||
| Y71F9AM.4b.1 | |||||||||
| Other_sequence (32) | |||||||||
| Associated_feature | WBsf654776 | ||||||||
| WBsf983021 | |||||||||
| WBsf983022 | |||||||||
| WBsf983023 | |||||||||
| WBsf1009428 | |||||||||
| WBsf217354 | |||||||||
| WBsf217355 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr3795 | ||||||||
| Expr1012232 | |||||||||
| Expr1039734 | |||||||||
| Expr1161584 | |||||||||
| Expr2010292 | |||||||||
| Expr2028534 | |||||||||
| Antibody | WBAntibody00000962 | ||||||||
| WBAntibody00000963 | |||||||||
| Microarray_results (40) | |||||||||
| Expression_cluster (97) | |||||||||
| SAGE_tag (13) | |||||||||
| Interaction (17) | |||||||||
| Map_info | Map | I | Position | -5.27601 | Error | 0.002917 | |||
| Positive | Positive_clone | Y71F9AM | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00011952 | ||||||||
| WBPaper00016602 | |||||||||
| WBPaper00026979 | |||||||||
| WBPaper00028363 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00041771 | |||||||||
| WBPaper00047001 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00064339 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
