WormBase Tree Display for Gene: WBGene00004808

WBGene00004808 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: F46A9
  Identity: Version: 1
    Name: CGC_name: skr-2 Person_evidence: WBPerson322
      Sequence_name: F46A9.4
      Molecular_name: F46A9.4
        F46A9.4.1
        CE10578
      Other_name: CELE_F46A9.4 Accession_evidence: NDB BX284601
      Public_name: skr-2
    DB_info: Database: AceView gene 1K47
        WormQTL gene WBGene00004808
        WormFlux gene WBGene00004808
        NDB locus_tag CELE_F46A9.4
        Panther gene CAEEL|WormBase=WBGene00004808|UniProtKB=G5EDD8
          family PTHR11165
        NCBI gene 172773
        RefSeq protein NM_060111.7
        TREEFAM TREEFAM_ID TF354233
        TrEMBL UniProtAcc G5EDD8
        UniProt_GCRP UniProtAcc G5EDD8
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: skr
    Allele (18)
    Strain: WBStrain00036598
    RNASeq_FPKM (74)
    GO_annotation (19)
    Ortholog (29)
    Paralog (19)
    Structured_description: Concise_description: skr-2 encodes a homolog of Skp1 in S. cerevisiae, a core component of the SCF (Skp1p, Cullin, F-box) ubiquitin-ligase complex that facilitates ubiquitin-mediated protein degradation; SKR-2 is required for the restraint of cell proliferation, progression through the pachytene stage of meiosis, and the formation of bivalent chromosomes at diakinesis; SKR-2::GFP is detected exclusively in the intestine. Paper_evidence: WBPaper00005128
            WBPaper00005129
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable cullin family protein binding activity. Involved in several processes, including establishment of mitotic spindle orientation; regulation of cell cycle; and regulation of protein stability. Part of SCF ubiquitin ligase complex. Expressed in intestine. Is an ortholog of human SKP1 (S-phase kinase associated protein 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F46A9.4
    Corresponding_transcript: F46A9.4.1
    Other_sequence: AF440506
    Associated_feature: WBsf656750
      WBsf976899
      WBsf976900
      WBsf976901
      WBsf218284
      WBsf218285
  Experimental_info: RNAi_result (69)
    Expr_pattern: Expr2438
      Expr1027946
      Expr1032387
      Expr1151309
      Expr2015850
      Expr2034083
    Drives_construct: WBCnstr00010828
      WBCnstr00035374
    Construct_product: WBCnstr00010828
      WBCnstr00035374
    Regulate_expr_cluster: WBPaper00050332:skr-1(RNAi)-skr-2(RNAi)_downregulated
    Antibody: WBAntibody00002336
      WBAntibody00002337
    Microarray_results (17)
    Expression_cluster (146)
    Interaction (260)
    WBProcess: WBbiopr:00000068
  Map_info: Map: I Position: 3.76667 Error: 0.000462
    Positive: Positive_clone: F46A9 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (22)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene