WormBase Tree Display for Gene: WBGene00003967
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| WBGene00003967 | Evidence | Person_evidence | WBPerson50 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | K08E3 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | pdr-1 | Person_evidence | WBPerson50 | |||||
| Sequence_name | K08E3.7 | ||||||||
| Molecular_name | K08E3.7a | ||||||||
| K08E3.7a.1 | |||||||||
| CE31713 | |||||||||
| K08E3.7b | |||||||||
| CE49347 | |||||||||
| K08E3.7c | |||||||||
| CE49203 | |||||||||
| K08E3.7b.1 | |||||||||
| K08E3.7b.2 | |||||||||
| K08E3.7c.1 | |||||||||
| Other_name | CELE_K08E3.7 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | pdr-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info (12) | |||||||||
| Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00026844 | ||||
| Accession_evidence | OMIM | 167000 | |||||||
| 211980 | |||||||||
| 600116 | |||||||||
| 607572 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 08 Jan 2018 00:00:00 | ||||||||
| Potential_model | DOID:0060368 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8607) | |||||
| DOID:12217 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8607) | ||||||
| DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8607) | ||||||
| DOID:14330 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8607) | ||||||
| DOID:2377 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8607) | ||||||
| DOID:4362 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8607) | ||||||
| DOID:2394 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8607) | ||||||
| Disease_relevance | Mutations in human PARK2/Parkin are associated with the juvenile form of Parkinson disease, adenocarcinomas of the ovary and lung, and susceptibility to Leprosy; the Parkin protein is a RING domain-containing E3 ubiquitin ligase, involved in proteasome-dependent degradation of proteins and protection against cellular and mitochondrial stress; in elegans, cytosolic and ER stress exerts specific toxicity in pdr-1/parkin mutants; the truncated PDR-1(delta aa24-247) allele, when expressed in a human cell culture system, exhibited an increased tendency to form aggregates, and an increased tendency of alpha-synuclein to co-localize in these aggregates was observed; in elegans, PDR-1 interacts with UBC-2, UBC-18 and UBC-15, homologs of the human E2 enzymes UbcH4/5, UbcH7/8 and Ubc6; PDR-1 also interacts with CHN-1, the homolog of human E4 enzyme CHIP, that interacts with human Parkin and enhances its E3 ligase activity; this C. elegans model recapitulates Parkin insolubility and aggregation similar to several AR-JP linked Parkin mutations. | Homo sapiens | Paper_evidence | WBPaper00026844 | |||||
| Accession_evidence | OMIM | 211980 | |||||||
| 167000 | |||||||||
| 600116 | |||||||||
| 607572 | |||||||||
| 602544 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 23 Jul 2013 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000144 | ||||||||
| WBDOannot00000464 | |||||||||
| WBDOannot00000465 | |||||||||
| Molecular_info | Corresponding_CDS | K08E3.7a | |||||||
| K08E3.7b | |||||||||
| K08E3.7c | |||||||||
| Corresponding_CDS_history | K08E3.7:wp84 | ||||||||
| Corresponding_transcript | K08E3.7a.1 | ||||||||
| K08E3.7b.1 | |||||||||
| K08E3.7b.2 | |||||||||
| K08E3.7c.1 | |||||||||
| Other_sequence | CR10168 | ||||||||
| CR10169 | |||||||||
| HBC27467_1 | |||||||||
| CBC02855_1 | |||||||||
| CJC13897_1 | |||||||||
| ES744084.1 | |||||||||
| CRC04525_1 | |||||||||
| Associated_feature | WBsf645734 | ||||||||
| WBsf226064 | |||||||||
| WBsf226065 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr3755 | ||||||||
| Expr3756 | |||||||||
| Expr1024946 | |||||||||
| Expr1031891 | |||||||||
| Expr1153989 | |||||||||
| Expr2014813 | |||||||||
| Expr2033047 | |||||||||
| Drives_construct | WBCnstr00011645 | ||||||||
| Construct_product | WBCnstr00011645 | ||||||||
| Regulate_expr_cluster | WBPaper00035654:pdr-1(gk448)_regulated | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (96) | |||||||||
| Interaction (46) | |||||||||
| WBProcess | WBbiopr:00000014 | ||||||||
| WBbiopr:00000015 | |||||||||
| WBbiopr:00000096 | |||||||||
| Map_info | Map | III | Position | 21.6783 | Error | 0.079263 | |||
| Positive | Positive_clone | K08E3 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (54) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
