WormBase Tree Display for Gene: WBGene00003967
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WBGene00003967 | Evidence | Person_evidence | WBPerson50 | ||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | K08E3 | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | pdr-1 | Person_evidence | WBPerson50 | |||||
Sequence_name | K08E3.7 | ||||||||
Molecular_name | K08E3.7a | ||||||||
K08E3.7a.1 | |||||||||
CE31713 | |||||||||
K08E3.7b | |||||||||
CE49347 | |||||||||
K08E3.7c | |||||||||
CE49203 | |||||||||
K08E3.7b.1 | |||||||||
K08E3.7b.2 | |||||||||
K08E3.7c.1 | |||||||||
Other_name | CELE_K08E3.7 | Accession_evidence | NDB | BX284603 | |||||
Public_name | pdr-1 | ||||||||
DB_info | Database (12) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info (12) | |||||||||
Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00026844 | ||||
Accession_evidence | OMIM | 167000 | |||||||
211980 | |||||||||
600116 | |||||||||
607572 | |||||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 08 Jan 2018 00:00:00 | ||||||||
Potential_model (7) | |||||||||
Disease_relevance | Mutations in human PARK2/Parkin are associated with the juvenile form of Parkinson disease, adenocarcinomas of the ovary and lung, and susceptibility to Leprosy; the Parkin protein is a RING domain-containing E3 ubiquitin ligase, involved in proteasome-dependent degradation of proteins and protection against cellular and mitochondrial stress; in elegans, cytosolic and ER stress exerts specific toxicity in pdr-1/parkin mutants; the truncated PDR-1(delta aa24-247) allele, when expressed in a human cell culture system, exhibited an increased tendency to form aggregates, and an increased tendency of alpha-synuclein to co-localize in these aggregates was observed; in elegans, PDR-1 interacts with UBC-2, UBC-18 and UBC-15, homologs of the human E2 enzymes UbcH4/5, UbcH7/8 and Ubc6; PDR-1 also interacts with CHN-1, the homolog of human E4 enzyme CHIP, that interacts with human Parkin and enhances its E3 ligase activity; this C. elegans model recapitulates Parkin insolubility and aggregation similar to several AR-JP linked Parkin mutations. | Homo sapiens | Paper_evidence | WBPaper00026844 | |||||
Accession_evidence | OMIM | 211980 | |||||||
167000 | |||||||||
600116 | |||||||||
607572 | |||||||||
602544 | |||||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 23 Jul 2013 00:00:00 | ||||||||
Models_disease_asserted | WBDOannot00000144 | ||||||||
WBDOannot00000464 | |||||||||
WBDOannot00000465 | |||||||||
Molecular_info | Corresponding_CDS | K08E3.7a | |||||||
K08E3.7b | |||||||||
K08E3.7c | |||||||||
Corresponding_CDS_history | K08E3.7:wp84 | ||||||||
Corresponding_transcript | K08E3.7a.1 | ||||||||
K08E3.7b.1 | |||||||||
K08E3.7b.2 | |||||||||
K08E3.7c.1 | |||||||||
Other_sequence | CR10168 | ||||||||
CR10169 | |||||||||
HBC27467_1 | |||||||||
CBC02855_1 | |||||||||
CJC13897_1 | |||||||||
ES744084.1 | |||||||||
CRC04525_1 | |||||||||
Associated_feature | WBsf645734 | ||||||||
WBsf226064 | |||||||||
WBsf226065 | |||||||||
Experimental_info | RNAi_result (11) | ||||||||
Expr_pattern | Expr3755 | ||||||||
Expr3756 | |||||||||
Expr1024946 | |||||||||
Expr1031891 | |||||||||
Expr1153989 | |||||||||
Expr2014813 | |||||||||
Expr2033047 | |||||||||
Drives_construct | WBCnstr00011645 | ||||||||
Construct_product | WBCnstr00011645 | ||||||||
Regulate_expr_cluster | WBPaper00035654:pdr-1(gk448)_regulated | ||||||||
Microarray_results (21) | |||||||||
Expression_cluster (96) | |||||||||
Interaction (46) | |||||||||
WBProcess | WBbiopr:00000014 | ||||||||
WBbiopr:00000015 | |||||||||
WBbiopr:00000096 | |||||||||
Map_info | Map | III | Position | 21.6783 | Error | 0.079263 | |||
Positive | Positive_clone | K08E3 | Inferred_automatically | From CDS info | |||||
From sequence, transcript, pseudogene data | |||||||||
Pseudo_map_position | |||||||||
Reference (54) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |