WormBase Tree Display for Gene: WBGene00002004
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| WBGene00002004 | Evidence | Paper_evidence | WBPaper00005342 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y53C10A | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | hsf-1 | Person_evidence | WBPerson1157 | |||||
| Sequence_name | Y53C10A.12 | ||||||||
| Molecular_name | Y53C10A.12 | ||||||||
| Y53C10A.12.1 | |||||||||
| CE22380 | |||||||||
| Y53C10A.12.2 | |||||||||
| Other_name | CELE_Y53C10A.12 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | hsf-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hsf | ||||||||
| Allele (276) | |||||||||
| Possibly_affected_by | WBVar02153033 | ||||||||
| Strain (20) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (91) | |||||||||
| Ortholog (42) | |||||||||
| Structured_description | Concise_description | hsf-1 encodes the C. elegans heat-shock transcription factor ortholog; HSF-1 functions as a transcriptional regulator of stress-induced gene expression whose activity is required for heat-shock and proteotoxicity response, larval development, innate immunity, and regulation of adult lifespan; HSF-1 binds bovine calmodulin in vitro in a calcium-dependent manner. | Paper_evidence | WBPaper00005342 | |||||
| WBPaper00005851 | |||||||||
| WBPaper00006377 | |||||||||
| WBPaper00024662 | |||||||||
| WBPaper00026999 | |||||||||
| WBPaper00027347 | |||||||||
| WBPaper00028353 | |||||||||
| WBPaper00028419 | |||||||||
| WBPaper00031011 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 04 May 2010 00:00:00 | ||||||||
| Automated_description | Enables several functions, including calmodulin binding activity; identical protein binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including ascaroside biosynthetic process; defense response to other organism; and positive regulation of metabolic process. Located in cytoplasm; nuclear body; and nuclear stress granule. Part of chromatin. Expressed in several structures, including germ cell; hypodermis; intestine; neurons; and somatic cell. Human ortholog(s) of this gene implicated in Huntington's disease and cataract 5 multiple types. Is an ortholog of human HSF1 (heat shock transcription factor 1) and HSF2 (heat shock transcription factor 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:12858 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5224) | ||||
| DOID:0110255 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5227) | ||||||
| DOID:83 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5227) | ||||||
| Disease_relevance | C. elegans is an effective model system to study heat-related pathologies like heat stroke; in elegans, a small heat shock protein (sHSP), HSP-16.1 has a protective effect against heat-induced necrosis; HSP-16.1 localizes to the golgi and functions together with the PMR-1/PMR1 Ca2+ and Mn2+ transporting ATPase, and NUCB-1/Nucleobindin1, a golgi-located calcium-buffering protein, to maintain calcium homeostasis, under heat stroke; overexpresiion of pmr-1/PMR1 is sufficient to promote survival after heat stroke, bypassing both HSF-1 and HSP-16.1, indicating that PMR-1/PMR1 functions downstream of both these genes. | Homo sapiens | Paper_evidence | WBPaper00041564 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 29 May 2013 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y53C10A.12 | |||||||
| Corresponding_transcript | Y53C10A.12.1 | ||||||||
| Y53C10A.12.2 | |||||||||
| Other_sequence (32) | |||||||||
| Associated_feature | WBsf665013 | ||||||||
| WBsf717585 | |||||||||
| WBsf978924 | |||||||||
| WBsf985423 | |||||||||
| WBsf220382 | |||||||||
| Gene_product_binds | WBsf919560 | ||||||||
| WBsf919561 | |||||||||
| WBsf919565 | |||||||||
| WBsf919566 | |||||||||
| WBsf919567 | |||||||||
| WBsf919568 | |||||||||
| WBsf919569 | |||||||||
| WBsf919570 | |||||||||
| WBsf919571 | |||||||||
| Transcription_factor | WBTranscriptionFactor000178 | ||||||||
| Experimental_info (11) | |||||||||
| Map_info | Map | I | Position | 13.0131 | Error | 0.000976 | |||
| Positive | Positive_clone | Y53C10A | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4416 | |||||||
| 5648 | |||||||||
| Reference (373) | |||||||||
| Method | Gene |
