WormBase Tree Display for Gene: WBGene00001402
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| WBGene00001402 | SMap | S_parent | Sequence | F21H12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | fbf-2 | Person_evidence | WBPerson320 | |||||
| Sequence_name | F21H12.5 | ||||||||
| Molecular_name | F21H12.5 | ||||||||
| F21H12.5.1 | |||||||||
| CE01916 | |||||||||
| Other_name | FBF2 | Paper_evidence | WBPaper00012973 | ||||||
| FBF | Paper_evidence | WBPaper00053101 | |||||||
| WBPaper00053705 | |||||||||
| CELE_F21H12.5 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | fbf-2 | ||||||||
| DB_info | Database | AceView | gene | 2G380 | |||||
| WormQTL | gene | WBGene00001402 | |||||||
| WormFlux | gene | WBGene00001402 | |||||||
| NDB | locus_tag | CELE_F21H12.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001402|UniProtKB=Q09312 | |||||||
| family | PTHR12537 | ||||||||
| NCBI | gene | 174017 | |||||||
| RefSeq | protein | NM_001381445.2 | |||||||
| SwissProt | UniProtAcc | Q09312 | |||||||
| TREEFAM | TREEFAM_ID | TF318622 | |||||||
| UniProt_GCRP | UniProtAcc | Q09312 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | fbf | ||||||||
| Allele (52) | |||||||||
| Legacy_information | [Gallegos M, Zhang B] fbf-2(RNAi) animals produce excess sperm and no oocytes (Mog phenotype). Encodes fem-3 PME RNA binding protein, 91% identical to FBF-1. Predicted gene F21H12.5 | ||||||||
| Strain | WBStrain00022611 | ||||||||
| WBStrain00022612 | |||||||||
| WBStrain00022628 | |||||||||
| WBStrain00022640 | |||||||||
| WBStrain00022665 | |||||||||
| WBStrain00022345 | |||||||||
| WBStrain00022394 | |||||||||
| WBStrain00022449 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (33) | |||||||||
| Paralog | WBGene00001401 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004239 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00022257 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004241 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004243 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004242 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004240 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| WBGene00004244 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00004245 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | fbf-2 encodes an RNA-binding protein that is one of 11 C. elegans members of the PUF family (Pumilio and FBF) of translational regulators; FBF-2 is nearly identical to FBF-1 with which it is largely redundant in regulating two aspects of germline development: 1)maintenance of stem cell proliferation, and 2)the hermaphroditic switch between spermatogenesis and oogenesis; in maintaining germline stem cells, the FBF proteins, acting through NOS-3, negatively regulate the activity of gld-1 mRNA, which encodes a translational repressor required for meiotic entry; in regulating the sperm-to-oocyte switch, the FBFs act downstream of GLD-3 to negatively regulate the activity of fem-3 mRNA, which encodes a novel protein required for germline sex determination; consistent with their role in germline development, FBF-1 and FBF-2 are expressed in the germline cytoplasm, becoming enriched in the mitotic region during the L4 larval and adult stages. | Paper_evidence | WBPaper00002949 | |||||
| WBPaper00005265 | |||||||||
| WBPaper00005566 | |||||||||
| WBPaper00006369 | |||||||||
| WBPaper00018711 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 24 Sep 2004 00:00:00 | ||||||||
| Automated_description | Enables mRNA 3'-UTR binding activity. Involved in negative regulation of translation. Located in P granule. Used to study obesity. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:9970 | Homo sapiens | Paper_evidence | WBPaper00061889 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 28 Jun 2022 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00001264 | ||||||||
| Molecular_info | Corresponding_CDS | F21H12.5 | |||||||
| Corresponding_transcript | F21H12.5.1 | ||||||||
| Other_sequence | EX544358.1 | ||||||||
| Oden_isotig19477 | |||||||||
| PP02603 | |||||||||
| PPC01861_1 | |||||||||
| EX564883.1 | |||||||||
| GW916430.1 | |||||||||
| CJC02888_1 | |||||||||
| Associated_feature | WBsf223129 | ||||||||
| Gene_product_binds | WBsf027922 | ||||||||
| WBsf899551 | |||||||||
| WBsf899552 | |||||||||
| WBsf899553 | |||||||||
| WBsf899554 | |||||||||
| Transcription_factor | WBTranscriptionFactor000103 | ||||||||
| Experimental_info | RNAi_result (70) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00005290 | ||||||||
| WBCnstr00036968 | |||||||||
| Construct_product | WBCnstr00005274 | ||||||||
| WBCnstr00015117 | |||||||||
| WBCnstr00036968 | |||||||||
| WBCnstr00040359 | |||||||||
| Regulate_expr_cluster | WBPaper00055804:FBF-1-FBF-2-associated_oogenic-enriched | ||||||||
| WBPaper00055804:FBF-1-FBF-2-associated_spermatogenic-enriched | |||||||||
| Antibody | WBAntibody00000785 | ||||||||
| WBAntibody00000965 | |||||||||
| WBAntibody00001086 | |||||||||
| Microarray_results (16) | |||||||||
| Expression_cluster (117) | |||||||||
| Interaction (93) | |||||||||
| Map_info | Map | II | Position | -0.523905 | Error | 0.013695 | |||
| Positive | Positive_clone | F21H12 | Author_evidence | (genome sequence, | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | Multi_point | 4304 | |||||||
| 4305 | |||||||||
| 4907 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (136) | |||||||||
| Picture | WBPicture0000013095 | ||||||||
| Remark | Data extracted from Zhang et al. (1997) | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
