WormBase Tree Display for Gene: WBGene00001401
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WBGene00001401 | SMap | S_parent | Sequence | H12I13 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | fbf-1 | Person_evidence | WBPerson320 | |||||
Sequence_name | H12I13.4 | ||||||||
Molecular_name | H12I13.4 | ||||||||
H12I13.4.1 | |||||||||
CE20960 | |||||||||
Other_name | FBF | Paper_evidence | WBPaper00053101 | ||||||
WBPaper00053705 | |||||||||
CELE_H12I13.4 | Accession_evidence | NDB | BX284602 | ||||||
Public_name | fbf-1 | ||||||||
DB_info | Database | AceView | gene | 2G370 | |||||
WormQTL | gene | WBGene00001401 | |||||||
WormFlux | gene | WBGene00001401 | |||||||
NDB | locus_tag | CELE_H12I13.4 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00001401|UniProtKB=Q9N5M6 | |||||||
family | PTHR12537 | ||||||||
NCBI | gene | 174016 | |||||||
RefSeq | protein | NM_062815.8 | |||||||
SwissProt | UniProtAcc | Q9N5M6 | |||||||
TREEFAM | TREEFAM_ID | TF318622 | |||||||
UniProt_GCRP | UniProtAcc | Q9N5M6 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | fbf | ||||||||
Allele (53) | |||||||||
Legacy_information | [Gallegos M, Zhang B] fbf-1(RNAi) animals produce excess sperm and no oocytes (Mog phenotype). Encodes fem-3 PME RNA binding protein, 91% identical to FBF-2 | ||||||||
Strain | WBStrain00022602 | ||||||||
WBStrain00022603 | |||||||||
WBStrain00022612 | |||||||||
WBStrain00022628 | |||||||||
WBStrain00022640 | |||||||||
WBStrain00022344 | |||||||||
WBStrain00022346 | |||||||||
WBStrain00022396 | |||||||||
WBStrain00022400 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (27) | |||||||||
Ortholog (33) | |||||||||
Paralog | WBGene00004239 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | |||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00001402 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Inparanoid_8 | |||||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00022257 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Inparanoid_8 | |||||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00004241 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Inparanoid_8 | |||||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00004243 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00004242 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00004240 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Inparanoid_8 | |||||||||
WBGene00004244 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00004245 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | fbf-1 encodes an RNA-binding protein that is one of 12 C. elegans members of the PUF family (Pumilio and FBF) of translational regulators; FBF-1 is nearly identical to FBF-2 with which it is largely redundant in regulating two aspects of germline development: 1) maintenance of stem cell proliferation, and 2) the hermaphroditic switch between spermatogenesis and oogenesis; FBF-1 also plays a role in regulating adaptation in the AWC chemosensory neuron by binding and enhancing translation of the egl-4 mRNA; in maintaining germline stem cells, the FBF proteins, acting through NOS-3, negatively regulate the activity of gld-1 mRNA, which encodes a translational repressor required for meiotic entry; in regulating the sperm-to-oocyte switch, the FBFs act downstream of GLD-3 to negatively regulate the activity of fem-3 mRNA, which encodes a novel protein required for germline sex determination; consistent with their role in germline development, FBF-1 and FBF-2 are expressed in the germline cytoplasm, becoming enriched in the mitotic region during the L4 larval and adult stages. | Paper_evidence | WBPaper00002949 | |||||
WBPaper00004396 | |||||||||
WBPaper00005265 | |||||||||
WBPaper00005566 | |||||||||
WBPaper00006369 | |||||||||
WBPaper00032496 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 17 Feb 2009 00:00:00 | ||||||||
Automated_description | Enables mRNA 3'-UTR binding activity. Involved in several processes, including germline cell cycle switching, mitotic to meiotic cell cycle; olfactory learning; and regulation of gene expression. Located in germ cell nucleus and perinuclear region of cytoplasm. Expressed in germ line. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | H12I13.4 | |||||||
Corresponding_transcript | H12I13.4.1 | ||||||||
Associated_feature | WBsf650110 | ||||||||
WBsf1012315 | |||||||||
WBsf223128 | |||||||||
Gene_product_binds | WBsf027922 | ||||||||
WBsf034330 | |||||||||
Transcription_factor | WBTranscriptionFactor000123 | ||||||||
WBTranscriptionFactor000103 | |||||||||
Experimental_info | RNAi_result (58) | ||||||||
Expr_pattern (14) | |||||||||
Drives_construct | WBCnstr00005287 | ||||||||
WBCnstr00036969 | |||||||||
Construct_product | WBCnstr00000086 | ||||||||
WBCnstr00005234 | |||||||||
WBCnstr00036969 | |||||||||
WBCnstr00040358 | |||||||||
WBCnstr00042579 | |||||||||
Regulate_expr_cluster | WBPaper00035905:FBF-1_Associated | ||||||||
WBPaper00045618:fbf-1_downregulated | |||||||||
WBPaper00045618:fbf-1_upregulated | |||||||||
WBPaper00055804:FBF-1-FBF-2-associated_oogenic-enriched | |||||||||
WBPaper00055804:FBF-1-FBF-2-associated_spermatogenic-enriched | |||||||||
Antibody | WBAntibody00000156 | ||||||||
WBAntibody00000784 | |||||||||
WBAntibody00000964 | |||||||||
WBAntibody00001086 | |||||||||
WBAntibody00002142 | |||||||||
WBAntibody00002385 | |||||||||
Microarray_results (20) | |||||||||
Expression_cluster (131) | |||||||||
Interaction (89) | |||||||||
Map_info | Map | II | Position | -0.571982 | Error | 0.010563 | |||
Positive | Positive_clone | H12I13 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Y56A9 | |||||||||
Mapping_data | Multi_point | 4304 | |||||||
4305 | |||||||||
5274 | |||||||||
Pseudo_map_position | |||||||||
Reference (142) | |||||||||
Picture | WBPicture0000013095 | ||||||||
Remark | Data extracted from Zhang et al. (1997) | ||||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
Method | Gene |