WormBase Tree Display for Gene: WBGene00009218
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| WBGene00009218 | SMap | S_parent | Sequence | F28D1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | acs-20 | Person_evidence | WBPerson237 | |||||
| WBPerson2239 | |||||||||
| Sequence_name | F28D1.9 | ||||||||
| Molecular_name | F28D1.9 | ||||||||
| F28D1.9.1 | |||||||||
| CE47963 | |||||||||
| Other_name | CELE_F28D1.9 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | acs-20 | ||||||||
| DB_info | Database | AceView | gene | 4N158 | |||||
| WormQTL | gene | WBGene00009218 | |||||||
| WormFlux | gene | WBGene00009218 | |||||||
| NDB | locus_tag | CELE_F28D1.9 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00009218|UniProtKB=Q19878 | |||||||
| family | PTHR43107 | ||||||||
| NCBI | gene | 178190 | |||||||
| RefSeq | protein | NM_069966.10 | |||||||
| TrEMBL | UniProtAcc | Q19878 | |||||||
| UniProt_GCRP | UniProtAcc | Q19878 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:50 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 11 Sep 2008 09:57:25 | WBPerson2970 | Name_change | CGC_name | acs-20 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | acs | ||||||||
| Allele (88) | |||||||||
| Strain | WBStrain00004736 | ||||||||
| WBStrain00004747 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00066220 | ||||||||
| 00066221 | |||||||||
| 00066222 | |||||||||
| 00066223 | |||||||||
| 00066224 | |||||||||
| 00066225 | |||||||||
| 00066226 | |||||||||
| 00066227 | |||||||||
| Ortholog (42) | |||||||||
| Paralog (17) | |||||||||
| Structured_description | Concise_description | acs-20 encodes a protein homologous to the mammalian FATP1 and FATP4 fatty acid transport proteins (FATP)/very long chain fatty acid acyl-CoA synthetases; acs-20 activity is required for proper cuticle development, specifically formation of a cuticle surface barrier that prevents penetration of small molecules; acs-20 may affect cuticle development via its role in incorporation of very long chain fatty acids, but not other fatty acids, into sphingomyelin; acs-20; acs-22 doubly mutant animals have moresevere cuticle barrier defects than acs-20 single mutants, suggesting that the two genes function redundantly; acs-20 defects can be rescued by human Fatp4; an ACS-20::GFP fusion protein is expressed in the hyp7 and seam hypodermis, as well as the vulval and anal muscles; in hypodermal cells, ACS-20 localizes in a reticular pattern suggestive of localization to the endoplasmic reticulum. | Paper_evidence | WBPaper00035868 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 03 Feb 2010 00:00:00 | ||||||||
| Automated_description | Predicted to enable long-chain fatty acid transporter activity and long-chain fatty acid-CoA ligase activity. Predicted to be involved in triglyceride homeostasis. Located in intracellular membrane-bounded organelle. Expressed in anal depressor muscle; anal sphincter muscle; head; hyp7 syncytium; and seam cell. Human ortholog(s) of this gene implicated in obesity. Is an ortholog of human SLC27A1 (solute carrier family 27 member 1) and SLC27A4 (solute carrier family 27 member 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9970 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10998) | ||||
| Molecular_info | Corresponding_CDS | F28D1.9 | |||||||
| Corresponding_CDS_history | F28D1.9:wp154 | ||||||||
| Corresponding_transcript | F28D1.9.1 | ||||||||
| Other_sequence (33) | |||||||||
| Associated_feature (13) | |||||||||
| Experimental_info | RNAi_result (23) | ||||||||
| Expr_pattern | Chronogram984 | ||||||||
| Expr5903 | |||||||||
| Expr8893 | |||||||||
| Expr8895 | |||||||||
| Expr1026843 | |||||||||
| Expr1034021 | |||||||||
| Expr1149741 | |||||||||
| Expr2009210 | |||||||||
| Expr2027447 | |||||||||
| Drives_construct | WBCnstr00002507 | ||||||||
| WBCnstr00007265 | |||||||||
| WBCnstr00013587 | |||||||||
| WBCnstr00013589 | |||||||||
| WBCnstr00022750 | |||||||||
| WBCnstr00022752 | |||||||||
| WBCnstr00032361 | |||||||||
| Construct_product | WBCnstr00007265 | ||||||||
| WBCnstr00013589 | |||||||||
| WBCnstr00022752 | |||||||||
| WBCnstr00022754 | |||||||||
| WBCnstr00032361 | |||||||||
| Microarray_results (17) | |||||||||
| Expression_cluster (233) | |||||||||
| Interaction (173) | |||||||||
| Map_info | Map | IV | Position | 5.90843 | Error | 0.002883 | |||
| Positive | Positive_clone | F28D1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (12) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
