WormBase Tree Display for Gene: WBGene00012767
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| WBGene00012767 | SMap | S_parent | Sequence | Y41E3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | fcd-2 | Paper_evidence | WBPaper00028405 | |||||
| Person_evidence | WBPerson1839 | ||||||||
| Sequence_name | Y41E3.9 | ||||||||
| Molecular_name | Y41E3.9a | ||||||||
| Y41E3.9a.1 | |||||||||
| CE40581 | |||||||||
| Y41E3.9b | |||||||||
| CE44662 | |||||||||
| Y41E3.9c | |||||||||
| CE45681 | |||||||||
| Y41E3.9b.1 | |||||||||
| Y41E3.9c.1 | |||||||||
| Other_name | CELE_Y41E3.9 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | fcd-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:54 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 08 Sep 2006 10:43:24 | WBPerson1847 | Name_change | CGC_name | fcd-2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | fcd | ||||||||
| Allele (247) | |||||||||
| Strain | WBStrain00028632 | ||||||||
| WBStrain00031832 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (12) | |||||||||
| Contained_in_operon | CEOP4581 | ||||||||
| CEOP4662 | |||||||||
| Ortholog (42) | |||||||||
| Structured_description | Concise_description | fcd-2 encodes an ortholog of the human gene FANCD2 (mutated in Fanconianemia, OMIM:227646) that is strongly required for resistance to DNAinterstrand crosslinking (ICL) agents, but not to ionizing radiation (IR);fcd-2 mutants are viable and dispensable for resistance to IR, meioticrecombination, and S-phase checkpoint activation, but are hypersensitiveto ICL agents; like its human ortholog, FCD-2 is monoubiquitylated andrecruited to chromosomal foci after ICL but not IR; transgenic expresssionof the FANCD2 gene in mutant FA-D2 cells rescues their abnormalsensitivity to mitomycin C, an agent that cross-links strands of DNA. | Paper_evidence | WBPaper00012861 | |||||
| WBPaper00012862 | |||||||||
| WBPaper00026620 | |||||||||
| WBPaper00028405 | |||||||||
| Curator_confirmed | WBPerson1823 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 06 Sep 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable DNA polymerase binding activity. Involved in nucleotide-excision repair and regulation of DNA-templated DNA replication. Located in nucleus. Expressed in germ line. Used to study Fanconi anemia. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group D2; breast cancer; and skin melanoma. Is an ortholog of human FANCD2 (FA complementation group D2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:13636 | Homo sapiens | Paper_evidence | WBPaper00036433 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 26 Jan 2021 00:00:00 | ||||||||
| Potential_model | DOID:0111083 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3585) | |||||
| DOID:13636 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3585) | ||||||
| DOID:8923 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3585) | ||||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3585) | ||||||
| Models_disease_asserted | WBDOannot00000494 | ||||||||
| WBDOannot00000846 | |||||||||
| Molecular_info | Corresponding_CDS | Y41E3.9a | |||||||
| Y41E3.9b | |||||||||
| Y41E3.9c | |||||||||
| Corresponding_CDS_history | Y41E3.9:wp162 | ||||||||
| Y41E3.9:wp167 | |||||||||
| Corresponding_transcript | Y41E3.9a.1 | ||||||||
| Y41E3.9b.1 | |||||||||
| Y41E3.9c.1 | |||||||||
| Other_sequence | CBC07468_1 | ||||||||
| EL889667.1 | |||||||||
| MCC01007_1 | |||||||||
| MH07475 | |||||||||
| EL887798.1 | |||||||||
| BMC12225_1 | |||||||||
| MHC09449_1 | |||||||||
| EL889269.1 | |||||||||
| Associated_feature | WBsf646572 | ||||||||
| WBsf660953 | |||||||||
| WBsf660954 | |||||||||
| WBsf998672 | |||||||||
| WBsf998673 | |||||||||
| WBsf998674 | |||||||||
| WBsf1018720 | |||||||||
| WBsf1018721 | |||||||||
| WBsf1018722 | |||||||||
| WBsf229550 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr8878 | ||||||||
| Expr1023457 | |||||||||
| Expr1035649 | |||||||||
| Expr1159900 | |||||||||
| Expr2011741 | |||||||||
| Expr2029979 | |||||||||
| Antibody | WBAntibody00001135 | ||||||||
| WBAntibody00001136 | |||||||||
| WBAntibody00001348 | |||||||||
| WBAntibody00002096 | |||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (130) | |||||||||
| Interaction | WBInteraction000032185 | ||||||||
| WBInteraction000052805 | |||||||||
| WBInteraction000249936 | |||||||||
| WBInteraction000540676 | |||||||||
| Map_info | Map | IV | Position | 12.8155 | Error | 0.001811 | |||
| Positive | Positive_clone | Y41E3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (29) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
