WormBase Tree Display for Gene: WBGene00004319
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| WBGene00004319 | Evidence | Paper_evidence | WBPaper00005813 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Person_evidence | WBPerson3621 | ||||||||
| CGC_data_submission | |||||||||
| SMap | S_parent | Sequence | ZK593 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | rbr-2 | Person_evidence | WBPerson545 | |||||
| Sequence_name | ZK593.4 | ||||||||
| Molecular_name | ZK593.4a | ||||||||
| ZK593.4a.1 | |||||||||
| CE35704 | |||||||||
| ZK593.4b | |||||||||
| CE49883 | |||||||||
| ZK593.4b.1 | |||||||||
| Other_name | rbp-2 | ||||||||
| CELE_ZK593.4 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | rbr-2 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | rbr | ||||||||
| Allele (76) | |||||||||
| Strain | WBStrain00032626 | ||||||||
| WBStrain00040875 | |||||||||
| WBStrain00000040 | |||||||||
| WBStrain00000041 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (23) | |||||||||
| Ortholog (51) | |||||||||
| Paralog | WBGene00012982 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | rbr-2 encodes a histone H3 lysine 4 (H3K4) demethylase orthologous to budding yeast Jhd2p, Drosophila LID, and human JARID1A (OMIM:180202), JARID1B (OMIM:605393), JARID1C OMIM:314690, mutated in mental retardation), and JARID1D (OMIM:426000); RBR-2 regulates genome-wide levels of H3K4 trimethylation and is required in the germ line for normally short lifespan; recombinant His-RBR-2 specifically demethylates H3K4me3/me2 in vitro; rbr-2 is also required for reliable vulval development, and interacts genetically with CLK-2, GLP-1, LIN-15, and SEM-5; rbr-2(tm1231) homozygotes display excess trimethylated H3K4 (H3K4me3) and erratic vulval development (either vulvaless or multivulva); rbr-2(RNAi) animals show extended lifespans, a strong synthetic multivulva and H3K4me3 phenotype in a lin-15(n765ts) mutant background at permissive temperature, and abnormally slow growth with clk-2(mn159), glp-1(or178), or sem-5(n2019) mutant backgrounds; an RBR-2::GFP fusion protein is widely expressed and localizes to nuclei. | Paper_evidence | WBPaper00005813 | |||||
| WBPaper00005976 | |||||||||
| WBPaper00028564 | |||||||||
| WBPaper00029134 | |||||||||
| WBPaper00031036 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 09 Mar 2008 00:00:00 | ||||||||
| Automated_description | Enables histone H3K4me/H3K4me2/H3K4me3 demethylase activity. Involved in determination of adult lifespan and regulation of vulval development. Located in nucleus. Expressed in several structures, including anchor cell and vulval precursor cell. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease of musculoskeletal system (multiple); gastrointestinal system cancer (multiple); and intellectual disability (multiple). Is an ortholog of several human genes including KDM5A (lysine demethylase 5A); KDM5C (lysine demethylase 5C); and KDM5D (lysine demethylase 5D). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (18) | ||||||||
| Molecular_info | Corresponding_CDS | ZK593.4a | |||||||
| ZK593.4b | |||||||||
| Corresponding_CDS_history | ZK593.4:wp109 | ||||||||
| Corresponding_transcript | ZK593.4a.1 | ||||||||
| ZK593.4b.1 | |||||||||
| Other_sequence (16) | |||||||||
| Associated_feature | WBsf978358 | ||||||||
| WBsf981817 | |||||||||
| WBsf997728 | |||||||||
| WBsf1018154 | |||||||||
| WBsf229063 | |||||||||
| WBsf229064 | |||||||||
| WBsf229065 | |||||||||
| Transcription_factor | WBTranscriptionFactor001121 | ||||||||
| Experimental_info | RNAi_result (21) | ||||||||
| Expr_pattern | Expr9085 | ||||||||
| Expr12705 | |||||||||
| Expr13089 | |||||||||
| Expr1022048 | |||||||||
| Expr1032144 | |||||||||
| Expr1162943 | |||||||||
| Expr2015275 | |||||||||
| Expr2033509 | |||||||||
| Drives_construct | WBCnstr00013710 | ||||||||
| WBCnstr00022658 | |||||||||
| WBCnstr00035566 | |||||||||
| Construct_product | WBCnstr00013710 | ||||||||
| WBCnstr00016615 | |||||||||
| WBCnstr00022658 | |||||||||
| WBCnstr00035566 | |||||||||
| Regulate_expr_cluster | WBPaper00050080:rbr-2(tm3141)_downregulated | ||||||||
| WBPaper00050080:rbr-2(tm3141)_upregulated | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (141) | |||||||||
| Interaction (57) | |||||||||
| Map_info | Map | IV | Position | 4.73496 | Error | 0.003365 | |||
| Positive | Positive_clone | ZK593 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4263 | |||||||
| Pseudo_map_position | |||||||||
| Reference (26) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
