WormBase Tree Display for Gene: WBGene00010369
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| WBGene00010369 | SMap | S_parent | Sequence | H06O01 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | chd-1 | Person_evidence | WBPerson260 | |||||
| Sequence_name | H06O01.2 | ||||||||
| Molecular_name | H06O01.2 | ||||||||
| H06O01.2.1 | |||||||||
| CE32454 | |||||||||
| Other_name | CELE_H06O01.2 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | chd-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:51 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 30 Sep 2011 16:40:16 | WBPerson2970 | Name_change | CGC_name | chd-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | chd | ||||||||
| Allele (91) | |||||||||
| Strain | WBStrain00033287 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (14) | |||||||||
| Ortholog (42) | |||||||||
| Paralog (19) | |||||||||
| Structured_description | Concise_description | H06O01.2 encodes a large (1,461-aa) putative chromodomain helicaseDNA-binding protein that inhibits DHC-1 in vivo; H06O01.2 is orthologousto budding yeast CHD1, human CHD1 (OMIM:602118), and human CHD2(OMIM:602119); H06O01.2(RNAi) suppresses the lethality of conditional dhc-1 mutations, as well as the spindle length and cytokinesis defectsof dhc-1(or195), indicating that H06O01.2 negatively regulates dynein;H06O01.2 has no obvious function in mass RNAi assays. | Paper_evidence | WBPaper00030897 | |||||
| WBPaper00030910 | |||||||||
| WBPaper00030913 | |||||||||
| WBPaper00030915 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 26 Aug 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable several functions, including ATP hydrolysis activity; ATP-dependent chromatin remodeler activity; and chromatin binding activity. Predicted to be involved in nucleosome organization and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of chromatin. Expressed in several structures, including germ cell and somatic cell. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma and developmental and epileptic encephalopathy 94. Is an ortholog of human CHD1 (chromodomain helicase DNA binding protein 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0080909 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1915) | ||||
| DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1915) | ||||||
| DOID:0081325 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1917) | ||||||
| Molecular_info | Corresponding_CDS | H06O01.2 | |||||||
| Corresponding_CDS_history | H06O01.2:wp90 | ||||||||
| Corresponding_transcript | H06O01.2.1 | ||||||||
| Other_sequence (84) | |||||||||
| Associated_feature | WBsf664384 | ||||||||
| WBsf664385 | |||||||||
| WBsf664386 | |||||||||
| WBsf984049 | |||||||||
| WBsf1010014 | |||||||||
| WBsf219666 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00116963 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00003875 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001022 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00081577 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00113475 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00075562 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00049332 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00003874 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00116962 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr16307 | ||||||||
| Expr16308 | |||||||||
| Expr1018394 | |||||||||
| Expr1034528 | |||||||||
| Expr1153070 | |||||||||
| Expr2009955 | |||||||||
| Expr2028195 | |||||||||
| Drives_construct | WBCnstr00031462 | ||||||||
| Construct_product | WBCnstr00031462 | ||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (109) | |||||||||
| Interaction (71) | |||||||||
| Map_info | Map | I | Position | 1.63154 | Error | 0.008067 | |||
| Positive | Positive_clone | H06O01 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00015650 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00047313 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00062707 | |||||||||
| WBPaper00063052 | |||||||||
| WBPaper00065308 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
