The fil-tering criteria were: 1% FDR at both the peptide level and the protein level; precursor mass toler-ance, 20 ppm; fragment mass tolerance, 20 ppm; the peptide length, 6100 aa. To identify high-confidence candidate interacting proteins, The WD-Scores of proteins identified in each IP-MS sam-ple were calculated against the identification results of 71 unrelated IP-MS samples, according tothe formulas from the CompPASS tutorial.