WormBase Tree Display for Gene: WBGene00002025
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| WBGene00002025 | Evidence | Paper_evidence | WBPaper00005851 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y22D7AL | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | hsp-60 | Person_evidence | WBPerson36 | |||||
| Sequence_name | Y22D7AL.5 | ||||||||
| Molecular_name | Y22D7AL.5a | ||||||||
| Y22D7AL.5a.1 | |||||||||
| CE27244 | |||||||||
| Y22D7AL.5b | |||||||||
| CE42184 | |||||||||
| Y22D7AL.5c | |||||||||
| CE49133 | |||||||||
| Y22D7AL.5a.2 | |||||||||
| Y22D7AL.5b.1 | |||||||||
| Y22D7AL.5c.1 | |||||||||
| Other_name | HSP60 | Accession_evidence | EMBL | L36035 | |||||
| CELE_Y22D7AL.5 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | hsp-60 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hsp | ||||||||
| Allele (155) | |||||||||
| Strain | WBStrain00034066 | ||||||||
| WBStrain00037526 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog (45) | |||||||||
| Paralog | WBGene00000377 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00000378 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00000379 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00000380 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00000381 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00004089 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00018782 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00020391 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00021934 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | hsp-60 encodes a nuclear-encoded mitochondrion-specific chaperone that is a member of the GroE/Hsp10/60 superfamily of molecular chaperones; hsp-60 is involved in the mitochondrial unfolded protein response, as hsp-60 expression, normally broadly detected during development, is greatly increased in response to treatments that disrupt mitochondrial protein handling; loss of hsp-60 activity via RNAi results in severe growth defects with arrest at embryonic and early larval stages of development. | Paper_evidence | WBPaper00024269 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 23 Oct 2012 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including mitochondrial unfolded protein response; mitochondrion organization; and nematode larval development. Located in mitochondrion. Expressed in hypodermis; intestine; muscle cell; and neurons. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Down syndrome; artery disease (multiple); and autoimmune disease of musculoskeletal system (multiple). Is an ortholog of human HSPD1 (heat shock protein family D (Hsp60) member 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (15) | ||||||||
| Molecular_info | Corresponding_CDS | Y22D7AL.5a | |||||||
| Y22D7AL.5b | |||||||||
| Y22D7AL.5c | |||||||||
| Corresponding_CDS_history | Y22D7AL.5:wp187 | ||||||||
| Corresponding_transcript | Y22D7AL.5a.1 | ||||||||
| Y22D7AL.5a.2 | |||||||||
| Y22D7AL.5b.1 | |||||||||
| Y22D7AL.5c.1 | |||||||||
| Other_sequence (127) | |||||||||
| Associated_feature | WBsf644960 | ||||||||
| WBsf658613 | |||||||||
| WBsf658614 | |||||||||
| WBsf658615 | |||||||||
| WBsf658616 | |||||||||
| WBsf658617 | |||||||||
| WBsf224464 | |||||||||
| WBsf224465 | |||||||||
| WBsf224466 | |||||||||
| WBsf224467 | |||||||||
| Experimental_info | RNAi_result (59) | ||||||||
| Expr_pattern | Expr11261 | ||||||||
| Expr11758 | |||||||||
| Expr13322 | |||||||||
| Expr1023094 | |||||||||
| Expr1031180 | |||||||||
| Expr1159196 | |||||||||
| Expr2012628 | |||||||||
| Expr2030864 | |||||||||
| Drives_construct | WBCnstr00005159 | ||||||||
| WBCnstr00019140 | |||||||||
| Construct_product | WBCnstr00016278 | ||||||||
| Antibody | WBAntibody00002183 | ||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (228) | |||||||||
| Interaction (340) | |||||||||
| WBProcess | WBbiopr:00000077 | ||||||||
| WBbiopr:00000079 | |||||||||
| Map_info | Map | III | Position | -20.099 | Error | 0.218513 | |||
| Positive | Positive_clone | Y22D7AL | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (58) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
