WormBase Tree Display for Gene: WBGene00002025
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WBGene00002025 | Evidence | Paper_evidence | WBPaper00005851 | ||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | Y22D7AL | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | hsp | ||||||
Allele (155) | |||||||
Strain | WBStrain00034066 | ||||||
WBStrain00037526 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (21) | |||||||
Ortholog (45) | |||||||
Paralog | WBGene00000377 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
WBGene00000378 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00000379 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00000380 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00000381 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00004089 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00018782 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00020391 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00021934 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | hsp-60 encodes a nuclear-encoded mitochondrion-specific chaperone that is a member of the GroE/Hsp10/60 superfamily of molecular chaperones; hsp-60 is involved in the mitochondrial unfolded protein response, as hsp-60 expression, normally broadly detected during development, is greatly increased in response to treatments that disrupt mitochondrial protein handling; loss of hsp-60 activity via RNAi results in severe growth defects with arrest at embryonic and early larval stages of development. | Paper_evidence | WBPaper00024269 | |||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 23 Oct 2012 00:00:00 | ||||||
Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including mitochondrial unfolded protein response; mitochondrion organization; and nematode larval development. Located in mitochondrion. Expressed in hypodermis; intestine; muscle cell; and neurons. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Down syndrome; artery disease (multiple); and autoimmune disease of musculoskeletal system (multiple). Is an ortholog of human HSPD1 (heat shock protein family D (Hsp60) member 1). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (15) | ||||||
Molecular_info | Corresponding_CDS | Y22D7AL.5a | |||||
Y22D7AL.5b | |||||||
Y22D7AL.5c | |||||||
Corresponding_CDS_history | Y22D7AL.5:wp187 | ||||||
Corresponding_transcript | Y22D7AL.5a.1 | ||||||
Y22D7AL.5a.2 | |||||||
Y22D7AL.5b.1 | |||||||
Y22D7AL.5c.1 | |||||||
Other_sequence (127) | |||||||
Associated_feature | WBsf644960 | ||||||
WBsf658613 | |||||||
WBsf658614 | |||||||
WBsf658615 | |||||||
WBsf658616 | |||||||
WBsf658617 | |||||||
WBsf224464 | |||||||
WBsf224465 | |||||||
WBsf224466 | |||||||
WBsf224467 | |||||||
Experimental_info | RNAi_result (59) | ||||||
Expr_pattern | Expr11261 | ||||||
Expr11758 | |||||||
Expr13322 | |||||||
Expr1023094 | |||||||
Expr1031180 | |||||||
Expr1159196 | |||||||
Expr2012628 | |||||||
Expr2030864 | |||||||
Drives_construct | WBCnstr00005159 | ||||||
WBCnstr00019140 | |||||||
Construct_product | WBCnstr00016278 | ||||||
Antibody | WBAntibody00002183 | ||||||
Microarray_results (30) | |||||||
Expression_cluster (228) | |||||||
Interaction (340) | |||||||
WBProcess | WBbiopr:00000077 | ||||||
WBbiopr:00000079 | |||||||
Map_info | Map | III | Position | -20.099 | Error | 0.218513 | |
Positive | Positive_clone | Y22D7AL | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Pseudo_map_position | |||||||
Reference (58) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |