WormBase Tree Display for Gene: WBGene00004736
expand all nodes | collapse all nodes | view schema
| WBGene00004736 | SMap | S_parent | Sequence | K11D9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | sca-1 | Person_evidence | WBPerson72 | |||||
| Sequence_name | K11D9.2 | ||||||||
| Molecular_name | K11D9.2a | ||||||||
| K11D9.2a.1 | |||||||||
| CE18884 | |||||||||
| K11D9.2b | |||||||||
| CE18885 | |||||||||
| K11D9.2c | |||||||||
| CE41682 | |||||||||
| K11D9.2b.1 | |||||||||
| K11D9.2b.2 | |||||||||
| K11D9.2c.1 | |||||||||
| Other_name | ser-1 | ||||||||
| mca-4 | Accession_evidence | EMBL | AJ012296 | ||||||
| CELE_K11D9.2 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | sca-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sca | ||||||||
| Allele (61) | |||||||||
| Strain | WBStrain00001157 | ||||||||
| WBStrain00037715 | |||||||||
| WBStrain00037790 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (41) | |||||||||
| Ortholog (47) | |||||||||
| Paralog (14) | |||||||||
| Structured_description | Concise_description | The sca-1 gene encodes a sarco-endoplasmic reticulum Ca[2+] ATPase homolog that is required for development and muscle function; sca-1 is also a ortholog of human ATP2A1 (OMIM:108730), which when mutated leads to Darier-White disease (OMIM:124200). | Paper_evidence | WBPaper00004103 | |||||
| WBPaper00004551 | |||||||||
| WBPaper00004979 | |||||||||
| Curator_confirmed | WBPerson1823 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables P-type calcium transporter activity and chromatin DNA binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; calcium ion import; and chemical homeostasis. Located in cytoplasmic vesicle and endomembrane system. Expressed in several structures, including egg-laying apparatus; excretory system; intestine; non-striated muscle; and spermatheca. Human ortholog(s) of this gene implicated in Brody myopathy; hypertension (multiple); and keratosis (multiple). Is an ortholog of human ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050606 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:812) | ||||
| DOID:2734 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:812) | ||||||
| DOID:10825 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:812) | ||||||
| DOID:6432 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:812) | ||||||
| DOID:0050692 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:811) | ||||||
| Molecular_info | Corresponding_CDS | K11D9.2a | |||||||
| K11D9.2b | |||||||||
| K11D9.2c | |||||||||
| Corresponding_transcript | K11D9.2a.1 | ||||||||
| K11D9.2b.1 | |||||||||
| K11D9.2b.2 | |||||||||
| K11D9.2c.1 | |||||||||
| Other_sequence (135) | |||||||||
| Associated_feature (40) | |||||||||
| Experimental_info | RNAi_result (43) | ||||||||
| Expr_pattern | Chronogram1740 | ||||||||
| Expr831 | |||||||||
| Expr832 | |||||||||
| Expr1816 | |||||||||
| Expr1011984 | |||||||||
| Expr1032336 | |||||||||
| Expr1154308 | |||||||||
| Expr2015613 | |||||||||
| Expr2033848 | |||||||||
| Drives_construct | WBCnstr00002049 | ||||||||
| WBCnstr00010467 | |||||||||
| WBCnstr00013254 | |||||||||
| WBCnstr00019729 | |||||||||
| WBCnstr00035421 | |||||||||
| Construct_product | WBCnstr00035421 | ||||||||
| Antibody | WBAntibody00000346 | ||||||||
| WBAntibody00000431 | |||||||||
| WBAntibody00000432 | |||||||||
| WBAntibody00000433 | |||||||||
| Microarray_results (42) | |||||||||
| Expression_cluster (202) | |||||||||
| Interaction (92) | |||||||||
| Map_info | Positive | Positive_clone | K11D9 | Inferred_automatically | From CDS info | ||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4828 | |||||||
| Interpolated_map_position | III | 5.41589 | |||||||
| Reference (21) | |||||||||
| Remark | ser-1 has sometimes been used to refer to his gene, but this is not correct as ser-1 is a serotonin receptor. | ||||||||
| Method | Gene |
