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WormBase Tree Display for Gene: WBGene00004736

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Name Class

WBGene00004736SMapS_parentSequenceK11D9
IdentityVersion1
NameCGC_namesca-1Person_evidenceWBPerson72
Sequence_nameK11D9.2
Molecular_nameK11D9.2a
K11D9.2a.1
CE18884
K11D9.2b
CE18885
K11D9.2c
CE41682
K11D9.2b.1
K11D9.2b.2
K11D9.2c.1
Other_nameser-1
mca-4Accession_evidenceEMBLAJ012296
CELE_K11D9.2Accession_evidenceNDBBX284603
Public_namesca-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:36WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classsca
Allele (61)
StrainWBStrain00001157
WBStrain00037715
WBStrain00037790
RNASeq_FPKM (74)
GO_annotation (41)
Ortholog (47)
Paralog (14)
Structured_descriptionConcise_descriptionThe sca-1 gene encodes a sarco-endoplasmic reticulum Ca[2+] ATPase homolog that is required for development and muscle function; sca-1 is also a ortholog of human ATP2A1 (OMIM:108730), which when mutated leads to Darier-White disease (OMIM:124200).Paper_evidenceWBPaper00004103
WBPaper00004551
WBPaper00004979
Curator_confirmedWBPerson1823
WBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables P-type calcium transporter activity and chromatin DNA binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; calcium ion import; and chemical homeostasis. Located in cytoplasmic vesicle and endomembrane system. Expressed in several structures, including egg-laying apparatus; excretory system; intestine; non-striated muscle; and spermatheca. Human ortholog(s) of this gene implicated in Brody myopathy; hypertension (multiple); and keratosis (multiple). Is an ortholog of human ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0050606Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:812)
DOID:2734Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:812)
DOID:10825Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:812)
DOID:6432Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:812)
DOID:0050692Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:811)
Molecular_infoCorresponding_CDSK11D9.2a
K11D9.2b
K11D9.2c
Corresponding_transcriptK11D9.2a.1
K11D9.2b.1
K11D9.2b.2
K11D9.2c.1
Other_sequence (135)
Associated_feature (40)
Experimental_infoRNAi_result (43)
Expr_patternChronogram1740
Expr831
Expr832
Expr1816
Expr1011984
Expr1032336
Expr1154308
Expr2015613
Expr2033848
Drives_constructWBCnstr00002049
WBCnstr00010467
WBCnstr00013254
WBCnstr00019729
WBCnstr00035421
Construct_productWBCnstr00035421
AntibodyWBAntibody00000346
WBAntibody00000431
WBAntibody00000432
WBAntibody00000433
Microarray_results (42)
Expression_cluster (202)
InteractionWBInteraction000005799
WBInteraction000033671
WBInteraction000033810
WBInteraction000034047
WBInteraction000035088
WBInteraction000035428
WBInteraction000038834
WBInteraction000042972
WBInteraction000045711
WBInteraction000052711
WBInteraction000140893
WBInteraction000151288
WBInteraction000157617
WBInteraction000161407
WBInteraction000173758
WBInteraction000177642
WBInteraction000182768
WBInteraction000194410
WBInteraction000201536
WBInteraction000218241
WBInteraction000223413
WBInteraction000224589
WBInteraction000238619
WBInteraction000248180
WBInteraction000251983
WBInteraction000256909
WBInteraction000259510
WBInteraction000277529
WBInteraction000280114
WBInteraction000285691
WBInteraction000287555
WBInteraction000296186
WBInteraction000306738
WBInteraction000306998
WBInteraction000330185
WBInteraction000330237
WBInteraction000335362
WBInteraction000338127
WBInteraction000357127
WBInteraction000367244
WBInteraction000368681
WBInteraction000371597
WBInteraction000375263
WBInteraction000379135
WBInteraction000383639
WBInteraction000400308
WBInteraction000402359
WBInteraction000403289
WBInteraction000411255
WBInteraction000417516
WBInteraction000422742
WBInteraction000426176
WBInteraction000446037
WBInteraction000455583
WBInteraction000456449
WBInteraction000502118
WBInteraction000502625
WBInteraction000519959
WBInteraction000520353
WBInteraction000520357
WBInteraction000520359
WBInteraction000521087
WBInteraction000523488
WBInteraction000524943
WBInteraction000537412
WBInteraction000537417
WBInteraction000548189
WBInteraction000548435
WBInteraction000549616
WBInteraction000551810
WBInteraction000552634
WBInteraction000554162
WBInteraction000559391
WBInteraction000562248
WBInteraction000564772
WBInteraction000565826
WBInteraction000567394
WBInteraction000568125
WBInteraction000569359
WBInteraction000569614
WBInteraction000570488
WBInteraction000571423
WBInteraction000571993
WBInteraction000572578
WBInteraction000572908
WBInteraction000576626
WBInteraction000580384
WBInteraction000582068
WBInteraction000582691
WBInteraction000582832
WBInteraction000585925
WBInteraction000586534
Map_infoPositivePositive_cloneK11D9Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4828
Interpolated_map_positionIII5.41589
Reference (21)
Remarkser-1 has sometimes been used to refer to his gene, but this is not correct as ser-1 is a serotonin receptor.
MethodGene